Results 101 to 110 of about 24,113 (230)

Frozen in Place: Proximity Labeling Maps Glial Interactomes Across Cell States

Glia, Volume 74, Issue 10, October 2026.
Proximity labeling enables cell‐type‐specific and spatially resolved mapping of glial protein networks. Proximity labeling approaches provide insights into glial function under physiological and pathological conditions. ABSTRACT Glial cells, including radial glia, oligodendrocyte precursor cells (OPCs), oligodendrocytes, astrocytes, and microglia, are ...
João Baltar, Rebecca Abati, Luísa Florido, Matthew G. Holt   +3 more
wiley   +1 more source

Immunophilin FK506 loaded in chitosan guide promotes peripheral nerve regeneration

, 2010
Immunophilin ligand FK506 has been treated as adjunct therapy for nerve repair due to its potent neurotrophic and neuroprotective actions. It was hypothesized that FK506 releasing from biodegradable chitosan guide provided better nerve regenerative ...
Wang, Wei, 马小军, Wei, Guoqiang, Li, Xiaoxia, Wang, Guanxiong, Zhang, Weiguo, Ma, Xiaojun   +6 more
core  

FK506 protects against articular cartilage collagenous extra-cellular matrix degradation [PDF]

, 2014
Objective: Osteoarthritis (OA) is a non-rheumatologic joint disease characterized by progressive degeneration of the cartilage extra-cellular matrix (ECM), enhanced subchondral bone remodeling, activation of synovial macrophages and osteophyte growth ...
Groen, Harald, van der Windt, A.E., Waarsing, J. H., Waarsing, J.H. (Jan), Windt, A.E. (Anna) van der, van der Windt, A. E., Müller, Caspar, Sandker, M. (Marjan), Weinans, H., Jahr, Holger, Sandker, Marjan, Jahr, H. (Holger), Groen, H.C., Jong, Marion, Siebelt, M. (Michiel), Jahr, H., Müller, C. (Cristina), Weinans, H.H. (Harrie), Groen, H.C. (Harald), Waarsing, Jan, Siebelt, Michiel, Groen, H. C., Jong, M. (Marcel) de, Sandker, M., de Jong, M., Waarsing, J.H., Müller, C., Weinans, HH, Siebelt, M., Windt, Anna   +29 more
core   +1 more source

Mitochondrial Fusion and Fission in Age‐Related Cardio‐Cerebral Diseases: Mechanisms and Interventions

Aging Cell, Volume 25, Issue 10, October 2026.
Mitochondrial fission‐fusion imbalance contributes to age‐related cardio‐cerebral diseases like Alzheimer's disease, Parkinson's disease, Cerebral Infarction, Arteriosclerosis, Myocardial Infarction, Cardiac valve disease, Hypertension, and Cardiomyopathy. This review summarizes its regulatory mechanisms and interventions.
Yuyao Yin, Zijian Li
wiley   +1 more source

Therapeutic Immune Reprogramming by Rapamycin Attenuates Plaque Inflammation and Lymphoid Immune Responses in Aged Atherosclerotic Mice

Aging Cell, Volume 25, Issue 10, October 2026.
Rapamycin exerts multifaceted immunomodulatory effects in age‐induced atherosclerosis, with pronounced inhibitory effects on adaptive immunity. Rapamycin reduced plaque inflammation and macrophage content, diminished pro‐inflammatory T cell responses, lowered age‐associated B cell frequencies, and attenuated senescence‐associated immune signatures ...
Jill de Mol, Daphne H. de Korte, Marie A. C. Depuydt, Virginia Smit, Mireia N. A. Bernabé Kleijn, Peter J. van Santbrink, Christoph J. Binder, Florentina Porsch, Frank H. Schaftenaar, Amanda C. Foks   +9 more
wiley   +1 more source

Evaluation of Synthetic FK506 Analogues as Ligands for the FK506-Binding Proteins 51 and 52

, 2016
The FK506-binding proteins (FKBP) 51 and 52 are cochaperones that modulate the signal transduction of steroid hormone receptors. Both proteins have been implicated in prostate cancer.
Ranganath Gopalakrishnan (849484), Bastiaan Hoogeland (1714330), Andreas Bracher (787273), Christian Kozany (26598), Steffen Gaali (2084515), Felix Hausch (383326), Christoph Kress (1955329)   +6 more
core   +1 more source

Chronic Pre‐Trauma Corticosterone Attenuates Trauma Memory Formation and Alters Gene Expression in Glucocorticoid Signalling Pathways

Genes, Brain and Behavior, Volume 25, Issue 5, October 2026.
The graphical abstract outlines the experimental workflow and key findings, showing how chronic or acute corticosterone elevations alter FC‐induced molecular and behavioural changes during trauma memory formation, consolidation, and recall. Abbreviations: Cort.—Corticosterone; FC—Fear Conditioning; PRPs—Plasticity‐Related Proteins.
Gia Kutelia, Zurab Kuchukashvili, Rusiko Ansiani, Roza Bukia, Manana Chikovani, Butsiko Chkhartishvili, Nanuli Doreulee   +6 more
wiley   +1 more source

Effects of nanoparticles with hydrotropic nicotinamide on tacrolimus: permeability through psoriatic skin and antipsoriatic and antiproliferative activities

International Journal of Nanomedicine, 2017
Tao Wan,* Wenhui Pan,* Yueming Long, Kaiyue Yu, Sibo Liu, Wenyi Ruan, Jingtong Pan, Mengyao Qin, Chuanbin Wu, Yuehong Xu Department of Pharmaceutics, School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, People’s Republic of China
Wan T, Pan W, Long Y, Yu K, Liu S, Ruan W, Pan J, Qin M, Wu C, Xu Y   +9 more
doaj  

Characterization of Sec14 Domain–Containing Proteins in the Malaria Parasite Plasmodium falciparum

Molecular Microbiology, Volume 126, Issue 4, Page 412-432, October 2026.
During asexual blood‐stage development, P. falciparum Sec14 proteins display distinct localizations suggesting specialized roles in lipid exchange. PfSec14‐1 initially localizes to the nucleus before moving to the ER and Golgi alongside PfSec14‐4 during schizogony.
Florian Lauruol, Dominik Šťastný, J. Pedro Fernandez‐Murray, Christopher R. McMaster, Peter Griač, Dave Richard   +5 more
wiley   +1 more source

Biosynthesis of Nonimmunosuppressive FK506 Analogues with Antifungal Activity

, 2019
A reduction in the strong immunosuppressive activity of FK506 (1) is essential for developing this compound as an antifungal agent. Seven new FK506 analogues modified at both the FK506-binding protein 12- and the calcineurin-binding regions were ...
Sang-Jun Ha, Sang-Jip Nam, Ji Yoon Beom, Yeonseon Lee, Yong-Sun Bahn, Ji Hoon Oh (4588465), Sang-Jun Ha (324799), Yeo Joon Yoon, Jin A Jung, Areum Hwangbo, Soo Jung Lee, Kyung-Tae Lee (1420105), Sang-Jip Nam (334832), Jin A Jung (3771907), Eunji Cheong (1759666), Myoung Chong Song (3771901), Eunji Cheong, Kyung-Tae Lee, Yeonseon Lee (7009505), Yong-Sun Bahn (210099), Yeo Joon Yoon (1931188), Myoung Chong Song, Areum Hwangbo (7009502), Ji Yoon Beom (2888402), Soo Jung Lee (136088), Ji Hoon Oh   +25 more
core   +1 more source