Results 101 to 110 of about 23,499 (227)
Immunophilin FK506 loaded in chitosan guide promotes peripheral nerve regeneration
, 2010 Immunophilin ligand FK506 has been treated as adjunct therapy for nerve repair due to its potent neurotrophic and neuroprotective actions. It was hypothesized that FK506 releasing from biodegradable chitosan guide provided better nerve regenerative ...
Wang, Wei +6 more
core
Development of Non-Immunosuppressive FK506 Derivatives as Antifungal and Neurotrophic Agents
, 2021 FK506, also known as tacrolimus, is a clinically important immunosuppressant drug and has promising therapeutic potentials owing to its antifungal, neuroprotective, and neuroregenerative activities. To generate various FK506 derivatives, the structure of
윤여준
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, 2010 Melanoma is a malignant skin cancer with high metastatic potential. The number of melanoma cases worldwide is increasing faster than any other cancer.
Romano, Simona, ROMANO SIMONA
core
Hydrogen peroxide mediates FK506-induced cytotoxicity in renal cells
, 2004 Hydrogen peroxide mediates FK506-induced cytotoxicity in renal cells.BackgroundThe nephrotoxicity induced by immunosuppressant FK506 remains a serious clinical problem, and the underlying mechanism has not been completely understood.
Wingo, Charles S. +6 more
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International Journal of Nanomedicine, 2017 Tao Wan,* Wenhui Pan,* Yueming Long, Kaiyue Yu, Sibo Liu, Wenyi Ruan, Jingtong Pan, Mengyao Qin, Chuanbin Wu, Yuehong Xu Department of Pharmaceutics, School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, People’s Republic of China
Wan T +9 more
doaj
FK506 and Cyclosporin A Enhance IL-6 Production in Monocytes: A single-Cell Assay
Mediators of Inflammation, 1994 The effect of FK506 and cyclosporin A (CsA) on the production of interleukin 6 (IL-6) in adherent monocytes was studied at a single-cell level by the avidinbiotin- peroxidase complex methods.
K. Murayama +5 more
doaj +1 more source
Characterization of the Biosynthetic Route to FK506 and Mutasynthesis of FK506 Analogues
, 2015 FK506은 면역억제활성을 갖고 있는 폴리케타이드로 다양한 Streptomyces 종에서 생산된다. 이는 장기 이식 환자의 이식거부반응 예방과 아토피성 피부염과 같은 자가면역질환의 치료제로 사용되고 있다. FK506 생합성에 관여하는 유전자들은 보고되어 있으나, FK506의 아릴기 (allyl functional group)와 post-PKS 변형에 관한 정확한 생합성 메커니즘은 밝혀지지 않았다.
반연희
core
Heterologous expression of FK506 in Streptomyces coelicolor M1146.
, 2013 A) HPLC-UV chromatograms showing production of FK506 in S. coelicolor M1146 after introduction of PAC20N containing the FK506 cluster. No production is observed upon introducing an empty pESAC13 vector. B) Extracted ion chromatograms of separate HPLC-ESI-
Andreas Kulik (432838) +5 more
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FKBP12 activates the cardiac ryanodine receptor Ca2+-release channel and is antagonised by FKBP12.6
, 2012 Changes in FKBP12.6 binding to cardiac ryanodine receptors (RyR2) are implicated in mediating disturbances in Ca2+-homeostasis in heart failure but there is controversy over the functional effects of FKBP12.6 on RyR2 channel gating.
Mano Sitsapesan (182017) +41 more
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Stroke Research and Treatment, 2012 Transient global cerebral ischemia causes loss of pyramidal cells in CA1 region of hippocampus. In this study, we investigated the neurotrophic effect of the immunosuppressant agent FK506 in rat after global cerebral ischemia.
Zahra-Nadia Sharifi +5 more
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