Results 111 to 120 of about 24,113 (230)

FKBP (FK506 Binding Protein)

, 2016
In the 70s, after a decade from the purification of cyclosporine, a selective immunosuppressant agent and potent tool in transplantation medicine, a novel molecule was purified from bacteria Streptomyces tsukubaensis.
D'ARRIGO, PAOLO, Paolo D’Arrigo, Rea, Anna, Maria Fiammetta Romano, Martina Tufano, ROMANO, MARIA FIAMMETTA, Simona Romano, Anna Rea, Tufano, Martina, ROMANO, SIMONA   +9 more
core   +1 more source

Regulatory orchestration of FK506 biosynthesis in Streptomyces tsukubaensis NRRL 18488 revealed through systematic analysis

iScience
Summary: Streptomyces tsukubaensis NRRL 18488, the primary producer of the immunosuppressant FK506, was analyzed to elucidate regulatory features of secondary metabolism.
Namil Lee, Woori Kim, Ji Hun Kim, Yongjae Lee, Soonkyu Hwang, Gahyeon Kim, Hyeseong Kim, Qingyun Dan, Matthias Schmidt, Yeo Joon Yoon, Suhyung Cho, Bernhard Palsson, Jay D. Keasling, Byung-Kwan Cho   +13 more
doaj   +1 more source

FK506 and Cyclosporin A Enhance IL-6 Production in Monocytes: A single-Cell Assay

Mediators of Inflammation, 1994
The effect of FK506 and cyclosporin A (CsA) on the production of interleukin 6 (IL-6) in adherent monocytes was studied at a single-cell level by the avidinbiotin- peroxidase complex methods.
K. Murayama, M. Sawamura, H. Murakami, J. Tamura, T. Naruse, J. Tsuchiya   +5 more
doaj   +1 more source

Chemobiosynthetic approach for production of FK506 analogues by Streptomyces sp. [PDF]

, 2017
FK506 (takrolimus) je makrolakton poliketidnega izvora z imunosupresivno aktivnostjo, ki ga proizvajajo nekatere streptomicetne vrste. Uporablja se kot imunosupresivno zdravilo za preprečevanje zavrnitve organov po presaditvi in zdravljenje vnetnih ...
Ramšak, Barbara
core  

Effects of FK506 on Hippocampal CA1 Cells Following Transient Global Ischemia/Reperfusion in Wistar Rat

Stroke Research and Treatment, 2012
Transient global cerebral ischemia causes loss of pyramidal cells in CA1 region of hippocampus. In this study, we investigated the neurotrophic effect of the immunosuppressant agent FK506 in rat after global cerebral ischemia.
Zahra-Nadia Sharifi, Farid Abolhassani, Mohammad Reza Zarrindast, Shabnam Movassaghi, Nasrin Rahimian, Gholamreza Hassanzadeh   +5 more
doaj   +1 more source

Harnessing calcineurin-FK506-FKBP12 crystal structures from invasive fungal pathogens to develop antifungal agents

Nature Communications, 2019
Calcineurin is important for fungal virulence and a potential antifungal target, but compounds targeting calcineurin, such as FK506, are immunosuppressive. Here we report the crystal structures of calcineurin catalytic (CnA) and regulatory (CnB) subunits
Praveen R. Juvvadi, David Fox, Benjamin G. Bobay, Michael J. Hoy, Sophie M. C. Gobeil, Ronald A. Venters, Zanetta Chang, Jackie J. Lin, Anna Floyd Averette, D. Christopher Cole, Blake C. Barrington, Joshua D. Wheaton, Maria Ciofani, Michael Trzoss, Xiaoming Li, Soo Chan Lee, Ying-Lien Chen, Mitchell Mutz, Leonard D. Spicer, Maria A. Schumacher, Joseph Heitman, William J. Steinbach   +21 more
doaj   +1 more source

Heterologous expression of FK506 in Streptomyces coelicolor M1146.

, 2013
A) HPLC-UV chromatograms showing production of FK506 in S. coelicolor M1146 after introduction of PAC20N containing the FK506 cluster. No production is observed upon introducing an empty pESAC13 vector. B) Extracted ion chromatograms of separate HPLC-ESI-
Andreas Kulik (432838), Mervyn J. Bibb (251589), Adam C. Jones (432837), Lutz Heide (194238), Mark J. Buttner (179216), Bertolt Gust (27573)   +5 more
core   +1 more source

Study of the effect of FKBP12 inhibitors on cancer cell apoptosis

, 2007
A growing number of evidence support the view that FK506 binding proteins (FKBPs) play a role in cancer survival and chemoresistance. A hyper-expression of FKBP12 was found associated with aggressive phenotype of childhood astrocytoma and FKBP51 has been
ROMANO, MARIA FIAMMETTA
core  

Tacrolimus (FK506) promotes placentation and maternal-fetal tolerance through modulating FASN-CEACAM1 pathway

Frontiers in Immunology
The establishment of placentation and maternal-fetal tolerance are important determinants of a successful pregnancy. Tacrolimus, also known as FK506, is a calcineurin inhibitor that has often been used for pregnant women after solid organ transplantation.
Xinhang Meng, Minfeng Shi, Jinfeng Qian, Yujie Luo, Liyuan Cui, Dajin Li, Songcun Wang   +6 more
doaj   +1 more source

EFFECT OF TEMPERATURE ON PLASMA CONCENTRATION OF FK506

The Japanese Journal of Urology, 1993
Because the affinity of FK506 for red blood cells is strong, plasma FK506 levels vary depending upon the temperature at which plasma is separated from whole blood. This study was undertaken to investigate the effects on plasma FK506 of blood temperature at the time of separation and of its rewarming at 37 degrees C, using A) blood samples from rats ...
openaire   +3 more sources