Results 111 to 120 of about 23,499 (227)

Study of the effect of FKBP12 inhibitors on cancer cell apoptosis

, 2007
A growing number of evidence support the view that FK506 binding proteins (FKBPs) play a role in cancer survival and chemoresistance. A hyper-expression of FKBP12 was found associated with aggressive phenotype of childhood astrocytoma and FKBP51 has been
ROMANO, MARIA FIAMMETTA
core  

Harnessing calcineurin-FK506-FKBP12 crystal structures from invasive fungal pathogens to develop antifungal agents

Nature Communications, 2019
Calcineurin is important for fungal virulence and a potential antifungal target, but compounds targeting calcineurin, such as FK506, are immunosuppressive. Here we report the crystal structures of calcineurin catalytic (CnA) and regulatory (CnB) subunits
Praveen R. Juvvadi, David Fox, Benjamin G. Bobay, Michael J. Hoy, Sophie M. C. Gobeil, Ronald A. Venters, Zanetta Chang, Jackie J. Lin, Anna Floyd Averette, D. Christopher Cole, Blake C. Barrington, Joshua D. Wheaton, Maria Ciofani, Michael Trzoss, Xiaoming Li, Soo Chan Lee, Ying-Lien Chen, Mitchell Mutz, Leonard D. Spicer, Maria A. Schumacher, Joseph Heitman, William J. Steinbach   +21 more
doaj   +1 more source

Discovery of FK506-sensitive and FK506-insensitive genes for use in future clinical trials of novel immunosuppressant compounds

, 2003
FK 506 is an immunosuppressant drug used to treat autoimmune disease and to prevent organ graft rejection. The purpose of this project was to discover FK506-sensitive and FK506-insensitive genes.
Maska, Sara Michelle
core  

Tacrolimus (FK506) promotes placentation and maternal-fetal tolerance through modulating FASN-CEACAM1 pathway

Frontiers in Immunology
The establishment of placentation and maternal-fetal tolerance are important determinants of a successful pregnancy. Tacrolimus, also known as FK506, is a calcineurin inhibitor that has often been used for pregnant women after solid organ transplantation.
Xinhang Meng, Minfeng Shi, Jinfeng Qian, Yujie Luo, Liyuan Cui, Dajin Li, Songcun Wang   +6 more
doaj   +1 more source

Formal total synthesis of (-)-FK506

, 1992
FK506 (2)* was isolated in 1987 by Fujisawa Pharmaceutical Co. in Japan from a strain of Streptomyces tsukubanesis (no. 9993). FK506 has been shown to be more potent than Cyclosporin A (1, CsA), the only anti-rejection drug currently used.
Chen, Kwunmin
core  

EFFECT OF TEMPERATURE ON PLASMA CONCENTRATION OF FK506

The Japanese Journal of Urology, 1993
Because the affinity of FK506 for red blood cells is strong, plasma FK506 levels vary depending upon the temperature at which plasma is separated from whole blood. This study was undertaken to investigate the effects on plasma FK506 of blood temperature at the time of separation and of its rewarming at 37 degrees C, using A) blood samples from rats ...
openaire   +3 more sources

Solution structure of FK506 bound to FKBP-12

, 1992
The complex of the immunosuppressant FK506 bound to FKBP-12 has been studied in solution using 1H and inverse-detected 13C NMR methods. The resonances of bound, 13C-labelled FK506 were assigned and a set of 66 intraligand NOE distance restraints were ...
Christopher A. Lepre, John A. Thomson, Jonathan M. Moore, Lepre, Christopher A., Thomson, John A., Moore, Jonathan M.   +5 more
core   +1 more source

Chemobiosynthetic approach for production of FK506 analogues by Streptomyces sp.

, 2017
FK506 (takrolimus) je makrolakton poliketidnega izvora z imunosupresivno aktivnostjo, ki ga proizvajajo nekatere streptomicetne vrste. Uporablja se kot imunosupresivno zdravilo za preprečevanje zavrnitve organov po presaditvi in zdravljenje vnetnih ...
Ramšak, Barbara
core   +1 more source

Use of FK506 Immunosuppressive Therapy in Pancreas Transplantation

, 1996
The purpose of this study was to evaluate the safety, efficacy, and transplant outcomes associated with FK506 rescue and maintenance therapy in pancreas transplant recipients.
Rita Alloway, Debra S Elmer, Donna K Hathaway, Trine Nyman, AO Gaber   +4 more
core   +1 more source

Tacrolimus (FK506) in Thoracic Organ Transplantation

Tacrolimus (FK506) was discovered as the result of a systematic screening program to look for an improved immunosuppressant. In the mid-1980s Goto and associates from the Exploratory Research Laboratories of Fujisawa Pharmaceutical Co.
Pham, S. M., Gammie, J. S.
core   +1 more source