Results 91 to 100 of about 23,499 (227)

Immunosuppressant FK506 induces interleukin-6 production through the activation of transcription factor nuclear factor (NF)-κB implications for FK506 nephropathy

, 1996
FK506 is a powerful immunosuppressive drug currently in use that inhibits the activation of several transcription factors (nuclear factor (NF)-AT and NF-κB) critical for T cell activation.
47489, Yoshioka, Katsuji, 47487, Sun, Xiangao, Miyazaki, Itsuo, 47488, 60115285, Shimizu, Kou-ichi, 142, Muraoka, Kei-ichi, 60200937, Bose, Jr. Henry, Yamamoto, Ken-ichi, Fujimoto, Koutaro, 47492, Yagi, Masao, 47493, 74, 47490, 47491   +19 more
core   +2 more sources

Venetoclax‐Integrated Conditioning Strategies Prior to Allogeneic Hematopoietic Stem Cell Transplantation in Myeloid Neoplasms: A Scoping Review of Emerging Evidence

European Journal of Haematology, Volume 117, Issue 1, Page 117-131, July 2026.
ABSTRACT Allogeneic hematopoietic stem cell transplantation (allo‐HSCT) remains the only potentially curative therapy for many patients with high‐risk myeloid neoplasms, yet relapse and transplant‐related toxicity continue to limit durable benefit.
Mohammed Abdulgayoom, Amaal Gulied, Awni Alshurafa, Shehab F. Mohamed, Mohamed A. Yassin, Afraa Fadul   +5 more
wiley   +1 more source

Biosynthesis of Nonimmunosuppressive FK506 Analogues with Antifungal Activity

, 2019
A reduction in the strong immunosuppressive activity of FK506 (1) is essential for developing this compound as an antifungal agent. Seven new FK506 analogues modified at both the FK506-binding protein 12- and the calcineurin-binding regions were ...
Sang-Jun Ha, Sang-Jip Nam, Ji Yoon Beom, Yeonseon Lee, Yong-Sun Bahn, Ji Hoon Oh (4588465), Sang-Jun Ha (324799), Yeo Joon Yoon, Jin A Jung, Areum Hwangbo, Soo Jung Lee, Kyung-Tae Lee (1420105), Sang-Jip Nam (334832), Jin A Jung (3771907), Eunji Cheong (1759666), Myoung Chong Song (3771901), Eunji Cheong, Kyung-Tae Lee, Yeonseon Lee (7009505), Yong-Sun Bahn (210099), Yeo Joon Yoon (1931188), Myoung Chong Song, Areum Hwangbo (7009502), Ji Yoon Beom (2888402), Soo Jung Lee (136088), Ji Hoon Oh   +25 more
core   +1 more source

Integrating tacrolimus into eutectic oil-based microemulsion for atopic dermatitis: simultaneously enhancing percutaneous delivery and treatment efficacy with relieving side effects

International Journal of Nanomedicine, 2019
Yixuan Wang, Sisi Cao, Kaiyue Yu, Fengdie Yang, Xiuming Yu, Yuanhao Zhai, Chuanbin Wu, Yuehong XuDepartment of Pharmaceutics, School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, People’s Republic of ChinaBackground: Topical
Wang Y, Cao S, Yu K, Yang F, Yu X, Zhai Y, Wu C, Xu Y   +7 more
doaj  

Phage p1-derived artificial chromosomes facilitate heterologous expression of the FK506 gene cluster.

PLoS ONE, 2013
We describe a procedure for the conjugative transfer of phage P1-derived Artificial Chromosome (PAC) library clones containing large natural product gene clusters (≥70 kilobases) to Streptomyces coelicolor strains that have been engineered for improved ...
Adam C Jones, Bertolt Gust, Andreas Kulik, Lutz Heide, Mark J Buttner, Mervyn J Bibb   +5 more
doaj   +1 more source

Effects of tacrolimus on autophagy protein LC3 in puromycin-damaged mouse podocytes

Journal of International Medical Research, 2020
Objective To investigate the mechanism through which tacrolimus, often used to treat refractory nephropathy, protects against puromycin-induced podocyte injury.
Xiao-qing Yang, Sheng-you Yu, Li Yu, Lin Ge, Yao Zhang, Zhi-hong Hao, Guo-sheng Liu   +6 more
doaj   +1 more source

FKBP (FK506 Binding Protein)

, 2016
In the 70s, after a decade from the purification of cyclosporine, a selective immunosuppressant agent and potent tool in transplantation medicine, a novel molecule was purified from bacteria Streptomyces tsukubaensis.
D'ARRIGO, PAOLO, Paolo D’Arrigo, Rea, Anna, Maria Fiammetta Romano, Martina Tufano, ROMANO, MARIA FIAMMETTA, Simona Romano, Anna Rea, Tufano, Martina, ROMANO, SIMONA   +9 more
core   +1 more source

Cyclic ADP-Ribose Requires FK506-Binding Protein to Regulate Intracellular Ca2+ Dynamics and Catecholamine Release in Acetylcholine-Stimulated Bovine Adrenal Chromaffin Cells

Journal of Pharmacological Sciences, 2006
.: The present study was undertaken to elucidate whether cyclic ADP-ribose (cADPR) mediates the amplification of Ca2+ signaling and catecholamine release via the involvement of FK506-binding proteins (FKBPs)/ryanodine receptor (RyR) in bovine adrenal ...
Morita Katsuya, Kitayama Tomoya, Kitayama Shigeo, Dohi Toshihiro   +3 more
doaj   +1 more source

Fk506 Promotes Melanocyte and Melanoblast Growth and Creates a Favourable Milieu for Cell Migration Via Keratinocytes: Possible Mechanisms of How Tacrolimus Ointment Induces Repigmentation in Patients with Vitiligo

, 2009
Background Vitiligo is an acquired pigmentary disorder characterized by depigmentation of skin and hair. As the pathogenesis of this disease is still obscure, the treatment of vitiligo has generally been unsatisfactory and often disappointing.
YU, HSIN-SU, 余幸司
core  

FK506 Controls CD40L-Induced Systemic Autoimmunity in Mice

, 2006
Autoimmunity results from loss of mechanisms controlling self-reactivity. Autoimmune disorders play an increasingly important role and CD40–CD40 ligand (CD40L) interaction on immunocompentent cells is able to break established immunotolerance.
Higuchi, Tetsuya, Luger, Thomas A., Balkow, Sandra, Annegret Kuhn, Stefan Beissert, Beissert, Stefan, Tetsuya Higuchi, Kuhn, Annegret, Karin Loser, Sandra Balkow, Jenny Apelt, Apelt, Jenny, Loser, Karin, Thomas A. Luger   +13 more
core   +1 more source