Results 91 to 100 of about 24,113 (230)

The role of acquired host immunity in periodontal diseases

Periodontology 2000, EarlyView.
Abstract The aim of this narrative review is to relate the contribution of European researchers to the complex topic of the host immune system in periodontal disease, focusing on acquired immunity. Other chapters in this volume will address the genetics and autoantibody responses and other forms of immunity to periodontal disease.
Denis F. Kinane, David F. Lappin, Shauna Culshaw   +2 more
wiley   +1 more source

FK506 in the maturation of dendritic cells

Haematologica, 2002
BACKGROUND AND OBJECTIVES: FK506 (tacrolimus) is a potent immunosuppressive agent that inhibits interleukin-2 (IL-2) and interferon-g production by CD4+ cells.
J Cos, T Villalba, R Parra, D Gallardo, I Bilbao, C Margarit, L Massuet   +6 more
doaj  

Effects of tacrolimus on autophagy protein LC3 in puromycin-damaged mouse podocytes

Journal of International Medical Research, 2020
Objective To investigate the mechanism through which tacrolimus, often used to treat refractory nephropathy, protects against puromycin-induced podocyte injury.
Xiao-qing Yang, Sheng-you Yu, Li Yu, Lin Ge, Yao Zhang, Zhi-hong Hao, Guo-sheng Liu   +6 more
doaj   +1 more source

Clearance of p16‐positive cardiac cells improves age‐related cardiac remodeling in mice

Experimental Physiology, EarlyView.
Abstract Senescent cells are characterized by expression of markers like p16 and secretion of profibrotic and proinflammatory factors. The role of cellular senescence in age‐related cardiac remodeling and dysfunction is incompletely understood. This study aimed to: (i) evaluate the effect of p16‐ positive cell clearance on cardiac function and ...
Mozhdeh Mehdizadeh, Martin Mackasey, Kimia Gharagozloo, Martin Aguilar, Patrice Naud, Allan Ochs, Nhung Vuong‐Robillard, Eric Thorin, Gerardo Ferbeyre, Jean‐Claude Tardif, Martin G. Sirois, Jean Francois Tanguay, Stanley Nattel   +12 more
wiley   +1 more source

Integrating tacrolimus into eutectic oil-based microemulsion for atopic dermatitis: simultaneously enhancing percutaneous delivery and treatment efficacy with relieving side effects

International Journal of Nanomedicine, 2019
Yixuan Wang, Sisi Cao, Kaiyue Yu, Fengdie Yang, Xiuming Yu, Yuanhao Zhai, Chuanbin Wu, Yuehong XuDepartment of Pharmaceutics, School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, People’s Republic of ChinaBackground: Topical
Wang Y, Cao S, Yu K, Yang F, Yu X, Zhai Y, Wu C, Xu Y   +7 more
doaj  

Exercise intolerance and impaired aerobic capacity in heart transplant recipients

Experimental Physiology, EarlyView.
Abstract Heart transplant recipients exhibit reduced exercise tolerance and persistently diminished aerobic capacity despite exercise training. Exercise tolerance depends on integrated oxygen transport and utilization, which are impaired in heart transplant recipients.
Fred W. Kolkhorst, Daniel T. Cannon, Harry B. Rossiter   +2 more
wiley   +1 more source

Characterization of the Biosynthetic Route to FK506 and Mutasynthesis of FK506 Analogues

, 2015
FK506은 면역억제활성을 갖고 있는 폴리케타이드로 다양한 Streptomyces 종에서 생산된다. 이는 장기 이식 환자의 이식거부반응 예방과 아토피성 피부염과 같은 자가면역질환의 치료제로 사용되고 있다. FK506 생합성에 관여하는 유전자들은 보고되어 있으나, FK506의 아릴기 (allyl functional group)와 post-PKS 변형에 관한 정확한 생합성 메커니즘은 밝혀지지 않았다.
반연희
core   +1 more source

Phage p1-derived artificial chromosomes facilitate heterologous expression of the FK506 gene cluster.

PLoS ONE, 2013
We describe a procedure for the conjugative transfer of phage P1-derived Artificial Chromosome (PAC) library clones containing large natural product gene clusters (≥70 kilobases) to Streptomyces coelicolor strains that have been engineered for improved ...
Adam C Jones, Bertolt Gust, Andreas Kulik, Lutz Heide, Mark J Buttner, Mervyn J Bibb   +5 more
doaj   +1 more source

Antioxidant supplementation blunts the proteome response to 3 weeks of sprint interval training preferentially in human type 2 muscle fibres

The Journal of Physiology, EarlyView.
Abstract figure legend Sprint interval training (SIT) is a popular time‐efficient type of endurance training. Healthy young men performed nine SIT sessions (4–6 × 30 s all‐out cycling sprints) over 3 weeks while being supplemented with antioxidants (high doses of vitamins C and E) or placebo. Muscle biopsies taken before and after the first SIT session
Victoria L. Wyckelsma, Marta Murgia, Sigitas Kamandulis, Stefano Gastaldello, Marius Brazaitis, Audrius Snieckus, Nerijus Eimantas, Mati Pääsuke, Sebastian Edman, William Apro, Daniel C. Andersson, Håkan Westerblad, Tomas Venckunas   +12 more
wiley   +1 more source

Fk506 Promotes Melanocyte and Melanoblast Growth and Creates a Favourable Milieu for Cell Migration Via Keratinocytes: Possible Mechanisms of How Tacrolimus Ointment Induces Repigmentation in Patients with Vitiligo

, 2009
Background Vitiligo is an acquired pigmentary disorder characterized by depigmentation of skin and hair. As the pathogenesis of this disease is still obscure, the treatment of vitiligo has generally been unsatisfactory and often disappointing.
YU, HSIN-SU, 余幸司
core