Results 71 to 80 of about 24,113 (230)

Administration of Ginkgo biloba Extract (EGb761) Alone and in Combination with FK506 Promotes Liver Regeneration in a Rat Model of Partial Hepatectomy

Balkan Medical Journal, 2018
Background: Free radical damage is known to occur during liver regeneration. The Ginkgo biloba extract EGb761 has antioxidant properties due to its ability to scavenge free radicals.
Nahide Ekici Günay, Sabahattin Muhtaroğlu, Abdulkadir Bedirli   +2 more
doaj   +1 more source

Repurposing antimicrobial agents for neuroprotection: Mechanisms, clinical potential, and challenges

Neuroprotection, EarlyView.
Antimicrobial agents exert neuroprotective effects through modulation of interconnected pathways. Tetracyclines, macrolides, antimalarial agents, sulfones, and antiparasitic agents suppress neuroinflammation, oxidative stress, and apoptosis while preserving mitochondrial function and neurotransmission.
Mohammad Amin Manavi, Mohammadreza Salehi, Razieh Mohammad Jafari, Ramin Goudarzi, Saman Khosravi, Ahmad Reza Dehpour   +5 more
wiley   +1 more source

Fk506 Inhibits Tumour Necrosis Factor-α Secretion in Human Keratinocytes Via Regulation of Nuclear Factor-κb

, 2009
Background Tacrolimus (FK506) ointment has been used for treatment of inflammatory dermatoses with remarkable success . Our previous studies have indicated that direct modulation of tacrolimus on keratinocytes (KCs) may have an impact on its therapeutic ...
YU, HSIN-SU, 余幸司
core  

Overview of FK506 in transplantation. [PDF]

, 1990
FK506 is a potent immunosuppressive agent which is undergoing clinical testing in liver, kidney, heart, and bone marrow transplantation. It has been shown to effectively prevent and reverse ongoing rejection in these models.
Tzakis, A, Martin, M, S. Todo, M. Jordan, Armitage, J, Abu-Elmagd, K, Jordan, M, Alessiani, M, Todo, S, K. Abu Elmagd, Shapiro, R, J. J. Fung, A. Tzakis, A. Jain, J. Armitage, Fung, JJ, Jain, A, R. Shapiro, M. Martin, ALESSIANI, MARIO   +19 more
core  

NMR assignments of the FK506-binding domain of FK506-binding protein 35 from Plasmodium vivax

, 2009
PvFKBP35 is a member of the FK506 binding protein family (FKBP) from Plasmodium vivax. The FK506- binding domain of PvFKBP35 shows a canonical peptidylprolyl cis–trans isomerase (PPIase) activity.
Yoon, Ho Sup, Shin, Joon, Alag, Reema
core   +1 more source

Image_3_Role of FK506-sensitive signals in asthmatic lung inflammation.tif

, 2022
Asthma is airway inflammatory diseases caused by the activation of group 2 innate lymphoid cells (ILC2s) and type 2 helper T (TH2) cells. Cysteine proteases allergen cause tissue damage to airway epithelial cells and activate ILC2-mediated type 2 airway ...
Masato Kubo (153266), Sewon Ki (16605), Yoshie Suzuki (153253), Yohei Mukoyama (14082531), Hiroshi Morimoto (583311), Kosuke Miyauchi (153241), Narumi Suzuki (10295331), Chihiro Tomiaki (14082528)   +7 more
core   +1 more source

Toxoplasma gondii Infection After Kidney Transplantation: A Case Report and Literature Review

Organ Medicine, EarlyView.
Toxoplasma gondii infection after kidney transplantation is rare and presents with nonspecific clinical manifestations; however, the associated mortality rate is high. We discuss the relevant literature, clinical manifestations, therapeutic regimens, and prognoses of post‐transplantation toxoplasmosis.
Peng Zhang, Xingqiang Lai, Rongxin Chen, Li Li, Jiali Fang, Guanghui Li, Junjie Ma, Luhao Liu, Zheng Chen   +8 more
wiley   +1 more source

Immunosuppressive drug interactions and resistance in mononuclear cells from renal transplant patients [PDF]

Existing anti-rejection drug regimes are inadequate since patients receive drugs despite serious side effects and poor response. New drugs are being developed which ultimately may allow for prescribing of rational, patient-specific immunosuppressive ...
Delaney, Michael Paul
core  

Hydrogen peroxide mediates FK506-induced cytotoxicity in renal cells [PDF]

, 2004
Hydrogen peroxide mediates FK506-induced cytotoxicity in renal cells.BackgroundThe nephrotoxicity induced by immunosuppressant FK506 remains a serious clinical problem, and the underlying mechanism has not been completely understood.
Wingo, Charles S., Agarwal, Anupam, Zhou, Xiaoming, Yang, Guang, Doi, Sonia Q., Davis, Christopher A., Hirszel, Przemyslaw   +6 more
core   +1 more source

Study on the Effect of Immunosuppressive Agent FK506 on Growth and Migration of Lung Cancer Cell

Chinese Journal of Lung Cancer, 2017
Background and objective FK506, also named tacrolimus, a new macrolide immunosuppressive agent, has been shown to possess anti-proliferation activities in some cancer cells.
Yongwen LI, Hongbing ZHANG, Ying LI, Chenlong ZHAO, Weiting LI, Hongyu LIU, Jianping WEN, Jun CHEN   +7 more
doaj   +1 more source