Results 51 to 60 of about 23,499 (227)

Biosynthesis of Nonimmunosuppressive FK506 Analogues with Antifungal Activity

, 2021
A reduction in the strong immunosuppressive activity of FK506 (1) is essential for developing this compound as an antifungal agent. Seven new FK506 analogues modified at both the FK506-binding protein 12- and the calcineurin-binding regions were ...
남상집, 윤여준, 송명종
core   +1 more source

Calcineurin Inhibitor CN585 Exhibits Off-Target Effects in the Human Fungal Pathogen Aspergillus fumigatus

Journal of Fungi, 2022
Calcineurin (CN) is an attractive antifungal target as it is critical for growth, stress response, drug resistance, and virulence in fungal pathogens.
Praveen R. Juvvadi, Benjamin G. Bobay, D. Christopher Cole, Monaf Awwa, William J. Steinbach   +4 more
doaj   +1 more source

Next Generation Hosts for Protein Recognition, Assembly and More

Chemistry – A European Journal, EarlyView.
The original design of synthetic receptors for proteins was based on macrocycles with a hydrophobic core and a polar/charged periphery. This design, geared towards protein recognition, facilitates receptor self‐assembly. Macrocycle oligomerization, in turn, contributes to protein assembly as evidenced in many cocrystal structures.
Peter B. Crowley
wiley   +1 more source

Dose-Sparing Topical Administration: FK506-Loaded Nano-Micelles Achieve Efficient Therapy in a Murine Model of Vernal Keratoconjunctivitis

Pharmaceuticals
Background/Objectives: Vernal keratoconjunctivitis (VKC) is a chronic, recurrent allergic disease with the risk of permanent injury or visual disabilities.
Zhen Liang, Ping Lu, Yuan Tao, Zhen Zhang, Fei Song, Huiyun Xia, Jijun He, Xiaping Yao, Fudan Dong, Junjie Zhang, Guojuan Pu, Tianyang Zhou   +11 more
doaj   +1 more source

FK506 immunosuppression for submandibular salivary gland allotransplantation in rabbit

, 2020
Objectives: We compared the outcomes of two different doses of FK506 (tacrolimus) for immunosuppression in submandibular salivary gland (SMG) allotransplantation. Materials and Methods: Three SMG allotransplantation groups were established (n=6 per group)
Kim, Soung Min, Ju, Kyung Won, Lee, Jong-Ho, Kim, Bongju, Almansoori, Akram Abdo, Khentii, Namuun   +5 more
core   +1 more source

Image_1_Role of FK506-sensitive signals in asthmatic lung inflammation.tif

, 2022
Asthma is airway inflammatory diseases caused by the activation of group 2 innate lymphoid cells (ILC2s) and type 2 helper T (TH2) cells. Cysteine proteases allergen cause tissue damage to airway epithelial cells and activate ILC2-mediated type 2 airway ...
Masato Kubo (153266), Sewon Ki (16605), Yoshie Suzuki (153253), Yohei Mukoyama (14082531), Hiroshi Morimoto (583311), Kosuke Miyauchi (153241), Narumi Suzuki (10295331), Chihiro Tomiaki (14082528)   +7 more
core   +1 more source

Protective effect of Korean Red Ginseng against FK506-induced damage in LLC-PK1 cells

Journal of Ginseng Research, 2017
Background: Compound FK506 is an immunosuppressant agent that is frequently used to prevent rejection of solid organs upon transplant. However, nephrotoxicity due to apoptosis and inflammatory response mediated by FK506 limit its usefulness.
Dahae Lee, Ki Sung Kang, Jae Sik Yu, Jung-Yoon Woo, Gwi Seo Hwang, Dae-Woon Eom, Seung-Hoon Baek, Hye Lim Lee, Ki Hyun Kim, Noriko Yamabe   +9 more
doaj   +1 more source

Resolving Endoplasmic Reticulum‐Protein Misfolding Restores Corticosteroid Sensitivity in Experimental Models of Severe Asthma

Allergy, EarlyView.
This study investigates the role of ER stress in steroid resistance in severe asthma. Results from advanced 3D models of human bronchial epithelial cells, steroid‐resistant severe asthma mouse models, and human severe asthma sputum samples show that treatment with ICS in combination with the ER stress inhibitor 4‐PBA significantly enhances steroid ...
Prabuddha S. Pathinayake, Alexandra C. Brown, Nikhil T. Awatade, Philip M. Hansbro, Katherine J. Baines, Richard Y. Kim, Nathan W. Bartlett, Jay C. Horvat, Peter A. B. Wark   +8 more
wiley   +1 more source

PRELIMINARY EXPERIENCE WITH FK506 IN THORACIC TRANSPLANTATION [PDF]

Transplantation, 1991
FK506, a potent immunosuppressive macrolide antibiotic, underwent initial clinical trails in liver recipients with intractable rejection or refractory drug toxicity (1,2). The dramatic results achieved by this agent in “rescue” therapy were followed shortly by its introduction as a primary immunosuppressant in kidney and liver recipients beginning in ...
Armitage, JM, Kormos, RL, Fung, J, Lavee, J, Fricker, FJ, Griffith, BP, Stuart, RS, Marrone, GC, Hardesty, RL, Todo, S, Tzakis, A, Starzl, TE   +11 more
openaire   +2 more sources

Image_2_Role of FK506-sensitive signals in asthmatic lung inflammation.tif

, 2022
Asthma is airway inflammatory diseases caused by the activation of group 2 innate lymphoid cells (ILC2s) and type 2 helper T (TH2) cells. Cysteine proteases allergen cause tissue damage to airway epithelial cells and activate ILC2-mediated type 2 airway ...
Masato Kubo (153266), Sewon Ki (16605), Yoshie Suzuki (153253), Yohei Mukoyama (14082531), Hiroshi Morimoto (583311), Kosuke Miyauchi (153241), Narumi Suzuki (10295331), Chihiro Tomiaki (14082528)   +7 more
core   +1 more source