Results 51 to 60 of about 24,113 (230)

Calcineurin Inhibitor CN585 Exhibits Off-Target Effects in the Human Fungal Pathogen Aspergillus fumigatus

Journal of Fungi, 2022
Calcineurin (CN) is an attractive antifungal target as it is critical for growth, stress response, drug resistance, and virulence in fungal pathogens.
Praveen R. Juvvadi, Benjamin G. Bobay, D. Christopher Cole, Monaf Awwa, William J. Steinbach   +4 more
doaj   +1 more source

Dual‐Dynamically Crosslinked Nanogels Enable Prolonged Ocular Retention for Multimodal Dry Eye Therapy

Advanced Science, EarlyView.
This berberine‐loaded dual‐dynamically crosslinked nanogel integrates tannic acid‐zinc metal‐phenolic networks and carboxymethyl chitosan/aldehyde‐functionalized poly(ethylene glycol) dynamic Schiff base networks, achieving 1‐year colloidal and antioxidant stability, sustained corneal berberine exposure for 24 h to support convenient once‐daily dosing,
Yanru Xin, Sisi Chen, Shengli Huang, Mengqi Huang, Jingyan Zhu, Zijian Wang, Jianliang Shen, Qinxiang Zheng   +7 more
wiley   +1 more source

Dose-Sparing Topical Administration: FK506-Loaded Nano-Micelles Achieve Efficient Therapy in a Murine Model of Vernal Keratoconjunctivitis

Pharmaceuticals
Background/Objectives: Vernal keratoconjunctivitis (VKC) is a chronic, recurrent allergic disease with the risk of permanent injury or visual disabilities.
Zhen Liang, Ping Lu, Yuan Tao, Zhen Zhang, Fei Song, Huiyun Xia, Jijun He, Xiaping Yao, Fudan Dong, Junjie Zhang, Guojuan Pu, Tianyang Zhou   +11 more
doaj   +1 more source

Effects of FK506-binding Protein 12 and FK506 on Autophosphorylation of Epidermal Growth Factor Receptor [PDF]

Journal of Biological Chemistry, 1998
FK506-binding proteins and cyclophilins are intracellular proteins that express peptidylproline cis-trans-isomerase (PPIase) activity. The effects of FK506-binding protein 12 (FKBP12) and the cyclophilins 18 and 23 on autophosphorylation of the epidermal growth factor (EGF) receptor prepared from plasma membranes of the human epidermoid cell line A431 ...
M, Lopez-Ilasaca, C, Schiene, G, Küllertz, T, Tradler, G, Fischer, R, Wetzker   +5 more
openaire   +2 more sources

Protective effect of Korean Red Ginseng against FK506-induced damage in LLC-PK1 cells

Journal of Ginseng Research, 2017
Background: Compound FK506 is an immunosuppressant agent that is frequently used to prevent rejection of solid organs upon transplant. However, nephrotoxicity due to apoptosis and inflammatory response mediated by FK506 limit its usefulness.
Dahae Lee, Ki Sung Kang, Jae Sik Yu, Jung-Yoon Woo, Gwi Seo Hwang, Dae-Woon Eom, Seung-Hoon Baek, Hye Lim Lee, Ki Hyun Kim, Noriko Yamabe   +9 more
doaj   +1 more source

The Calcineurin Inhibitor FK506 Prevents Cognitive Impairment by Inhibiting Reactive Astrogliosis in Pilocarpine-Induced Status Epilepticus Rats

Frontiers in Cellular Neuroscience, 2018
Status epilepticus (SE) is a severe clinical manifestation of epilepsy accompanying with cognitive impairment and brain damage. Astrocyte activation occurs following seizures and plays an important role in epilepsy-induced pathological injury, including ...
Jinzhi Liu, Zhihua Si, Shuqing Li, Zhan Huang, Yan He, Tao Zhang, Aihua Wang   +6 more
doaj   +1 more source

Harnessing bacterial extracellular vesicles for bone and cartilage organoids

BMEMat, EarlyView.
This review presents bacterial extracellular vesicles (BEVs) as programmable bioactive regulators for bone and cartilage organoids by delivering functional cargos that modulate skeletal remodeling. It highlights key engineering strategies and future directions to advance next‐generation organoid models for bone aging related diseases.
Han Liu, Xukun Lv, Ting Cheng, Lei Yan, Yuxiao Lai, Keying Guo, Yingying Jing, Hao Shen, Jiacan Su   +8 more
wiley   +1 more source

Immunosuppressant FK506 induces interleukin-6 production through the activation of transcription factor nuclear factor (NF)-κB implications for FK506 nephropathy [PDF]

, 1996
FK506 is a powerful immunosuppressive drug currently in use that inhibits the activation of several transcription factors (nuclear factor (NF)-AT and NF-κB) critical for T cell activation.
47489, Yoshioka, Katsuji, 47487, Sun, Xiangao, Miyazaki, Itsuo, 47488, 60115285, Shimizu, Kou-ichi, 142, Muraoka, Kei-ichi, 60200937, Bose, Jr. Henry, Yamamoto, Ken-ichi, Fujimoto, Koutaro, 47492, Yagi, Masao, 47493, 74, 47490, 47491   +19 more
core   +1 more source

Protective effect of FK506 combined with hypothermic mechanical perfusion on donor liver of rats [PDF]

Jichu yixue yu linchuang, 2021
Objective To investigate the protective effects of FK506 combined with low temperature mechanical perfusion on the reduction of ischemia reperfusion injury of rat liver transplants. Methods SD rats were divided into HTK group and FK506 + HTK group.
JIANG Li, LI Jian-hui, YU Hao, LI Hao-yu, XIE Hai-yang, ZHOU Lin, ZHENG Shu-sen
doaj  

From Caffeine to Aspirin: Everyday Molecules as Triggers for Genetically Encoded Proximity Systems

Chemistry – A European Journal, EarlyView.
This Perspective article highlights how familiar dietary ingredients and over‐the‐counter (OTC) drugs (such as caffeine and its metabolites, SA, and aspirin) can be repurposed as clinically translatable chemical triggers for genetically encoded proximity systems.
Mingguang Cui, Tianlu Wang, Yaoyu Han, Yun Huang, Tien‐Hung Lan, Yunbin Zhou   +5 more
wiley   +1 more source