Results 21 to 30 of about 36,346 (215)

Inhibition of Neovascularization and Inflammation in a Mouse Model of Corneal Alkali Burns Using Cationic Liposomal Tacrolimus

Frontiers in Bioengineering and Biotechnology, 2021
Eye drops account for more than 90% of commercialized ophthalmic drugs. However, eye drops have certain shortcomings, such as short precorneal retention time and weak corneal penetration.
Xueqi Lin, Xueqi Lin, Xuewen Yu, Xuewen Yu, Xiang Chen, Xiang Chen, Siting Sheng, Siting Sheng, Jingwen Wang, Jingwen Wang, Ben Wang, Ben Wang, Wen Xu, Wen Xu   +13 more
doaj   +1 more source

FK506 IN PEDIATRIC KIDNEY-TRANSPLANTATION - PRIMARY AND RESCUE EXPERIENCE [PDF]

, 1995
Between December 14, 1989, and December 17, 1993,43 patients undergoing kidney transplantation alone at the Children’s Hospital of Pittsburgh received FK506 as the primary immunosuppressive agent. The mean recipient age was 10.2 ± 4.8 years (range 0.7–17.
ELLIS, D, GILBOA, N, HAKALA, TR, HOPP, L, IRISH, W, JORDAN, ML, MCCAULEY, J, MITCHELL, S, SCANTLEBURY, VP, SHAPIRO, R, SIMMONS, RL, STARZL, TE, TZAKIS, AG, VIVAS, C   +13 more
core   +1 more source

Effect of Kaempferol on Tacrolimus-Induced Nephrotoxicity and Calcineurin B1 Expression Level in Animal Model [Corrigendum]

Journal of Experimental Pharmacology, 2023
Ali AS, Almalki AS, Alharthy BT. J Exp Pharmacol. 2020;12:397–407. The authors have advised that the Acknowledgments statement on page 405 is incorrect.
Ali AS, Almalki AS, Alharthy BT
doaj  

A prospective randomized trial of FK506-based immunosuppression after renal transplantation [PDF]

, 1995
A group of 204 adult patients was entered into a prospective, randomized trial comparing FK506/pred-nisone with FK506/azathioprine/prednisone after renal transplantation between August 1, 1991 and October 11,1992.
Demetris, AJ, Fung, JJ, Hakala, TR, Irish, W, Jordan, ML, McCauley, J, Mitchell, S, Randhawa, P, Scantlebury, VP, Shapiro, R, Simmons, RL, Starzl, TE, Vivas, C   +12 more
core   +1 more source

Controlled release of FK506 from micropatterned PLGA films: potential for application in peripheral nerve repair

Neural Regeneration Research, 2018
After decades of research, peripheral nerve injury and repair still frequently results in paralysis, chronic pain and neuropathies leading to severe disability in patients.
Brett Davis, Susan Wojtalewicz, Pratima Labroo, Jill Shea, Himanshu Sant, Bruce Gale, Jayant Agarwal   +6 more
doaj   +1 more source

Hamster-to-rat heart and liver xenotransplantation with FK506 plus antiproliferative drugs [PDF]

, 1993
Heterotopic hamster hearts transplanted to unmodified LEW rats underwent humoral rejection in 3 days. Survival was prolonged to a median of 4 days with 2 mg/kg/day FK506.
Cramer, D, Demetris, AJ, Makowka, L, Murase, N, Starzl, TE, Tanabe, M, Valdivia, L   +6 more
core   +1 more source

Characterization of the FKBP12-Encoding Genes in Aspergillus fumigatus. [PDF]

PLoS ONE, 2015
Invasive aspergillosis, largely caused by Aspergillus fumigatus, is responsible for a growing number of deaths among immunosuppressed patients. Immunosuppressants such as FK506 (tacrolimus) that target calcineurin have shown promise for antifungal drug ...
Katie Falloon, Praveen R Juvvadi, Amber D Richards, José M Vargas-Muñiz, Hilary Renshaw, William J Steinbach   +5 more
doaj   +1 more source

FK506 Induces the TGF-β1/Smad 3 Pathway Independently of Calcineurin Inhibition to Prevent Intervertebral Disk Degeneration

Frontiers in Cell and Developmental Biology, 2020
BackgroundIntervertebral disk (IVD) degeneration is the most common cause of lower back pain. Inhibiting inflammation is a key strategy for delaying IVD degeneration.
Jun Ge, Yingjie Wang, Qi Yan, Cenhao Wu, Hao Yu, Huilin Yang, Jun Zou   +6 more
doaj   +1 more source

InterAKTions with FKBPs - mutational and pharmacological exploration [PDF]

, 2013
The FK506-binding protein 51 (FKBP51) is an Hsp90-associated co-chaperone which regulates steroid receptors and kinases. In pancreatic cancer cell lines, FKBP51 was shown to recruit the phosphatase PHLPP to facilitate dephosphorylation of the kinase Akt,
Biondi, Ricardo M., Fabian, Anne-Katrin, Hausch, Felix, Kozany, Christian, März, Andreas, Neimanis, Sonja   +5 more
core   +3 more sources

Renal Tubular Acidosis Secondary to FK506 in Living Donor Liver Transplantation: A Case Report

Asian Journal of Surgery, 2003
FK506 is an immunosuppressant that is thought to be less nephrotoxic than cyclosporine A. However, complications due to renal tubular acidosis (RTA) have recently been reported.
Keiko Ogita, Narito Takada, Tomoaki Taguchi, Sachiyo Suita   +3 more
doaj   +1 more source