Results 61 to 70 of about 98,169 (229)

A destabilisation domain approach to define the in vivo functional importance of PfHsp70-1 and PfHsp40 in the intraerythrocytic life cycle of Plasmodium falciparum [PDF]

, 2017
The apicomplexan malaria parasite, Plasmodium falciparum is capable of invading red blood cells and causes the most virulent form of malaria. The life cycle of P. falciparum involves the migration from the poikilothermic mosquito vector to warm-blooded
Mandal, Pradipta
core   +1 more source

Combined Classical and Flooding Molecular Dynamics Simulations of The Mip-Rapamycin and FKBP12-Rapamycin Complexes

Jurnal Kimia Sains dan Aplikasi, 2023
Macrophage infectivity potentiator (Mip) protein, an essential virulence factor encoded by pathogenic bacteria such as Legionella pneumophila, arises as an interesting new therapeutic target for novel antimicrobials.
Elisabeth Catherina Widjajakusuma, Monica Frederica, Kornelius Kaweono   +2 more
doaj   +1 more source

Effects of combined administration of FK 506 and the purine biosynthesis inhibitors mizoribine or mycophenolic acid on lymphocyte DNA synthesis and T cell activation molecule expression in human mixed lymphocyte cultures [PDF]

, 1993
Our objective was to obtain new information on the in vitro antilymphocytic action of the cytokine synthesis inhibitor FK 506 and the purine biosynthesis inhibitors mycophenolic acid (MPA; the active moiety of RS61443) and mizoribine (MZB) when used ...
A. Zeevi, A.W. Thomson, Amemiya, Armitage, Downward, Eugui, Flanagan, Fung, G.Z. Yao, Gregory, J. Woo, Kiguchi, Kino, Ledbetter, Liu, Morris, Mustelin, O'Shea, Platz, S. Todo, Sawada, Schreiber, Shapiro, Sollinger, Starzl, Suzuki, T.E. Starzl, Thomson, Thomson, Tocci, Turka, Wilson, Woo, Woo, Zeevi   +34 more
core   +1 more source

Genome‐wide screen reveals a universal role of ATP in ciprofloxacin tolerance among genetically distinct Escherichia coli persisters

mLife, EarlyView.
Abstract Bacterial persisters show tolerance to bactericidal antibiotics and play essential roles in chronic infections; however, the general mechanisms underlying persister formation and antibiotic tolerance remain insufficiently characterized. In this study, the Escherichia coli Keio library was used to identify genes involved in ciprofloxacin ...
Zhenfang Mei, Yawen Cai, Jianfeng Huang, Kedong Zhao, Zuqin Zhang, Dandan Yu, Shiyan Lu, Zeying Lai, Thomas K. Wood, Xinmiao Fu   +9 more
wiley   +1 more source

Conditional targeting of MAD1 to kinetochores is sufficient to reactivate the spindle assembly checkpoint in metaphase [PDF]

, 2014
Fidelity of chromosome segregation is monitored by the spindle assembly checkpoint (SAC). Key components of the SAC include MAD1, MAD2, BUB1, BUB3, BUBR1, and MPS1.
A Antoni De, A Kulukian, A Musacchio, A Teichner, Adrian T. Saurin, AE Dick, AR Tipton, B Pinsky, BJ Howell, BJ Howell, C Ditchfield, C Klebig, CJ Morrow, DA Skoufias, DM Brady, E Wojcik, EMJ King, F Herzog, FG Westhorpe, G Fang, G Varetti, Geert J. P. L. Kops, GJPL Kops, GJPL Kops, GK Chan, J Davenport, J Maciejowski, J Mansfeld, J Pines, JC Waters, JK Famulski, JK Famulski, JL Burton, JM Sheltzer, JS Han, JS Rosenberg, K Uzunova, L Sironi, M Barisic, M Maldonado, M Mapelli, M Sczaniecka, M Simonetta, M Vleugel, Manja Omerzu, MW Moyle, N Jelluma, N London, P Clute, P Collin, P Lara-Gonzalez, R Basto, R Gassmann, S Elowe, S Hauf, S Kim, S Martin-Lluesma, S Santaguida, SA Foster, SK Reddy, SS Taylor, ST Liu, T Sliedrecht, Timo E. F. Kuijt, V Sudakin, V Vanoosthuyse, VM Rivera, WCH Chao, Z Tang, Z Yang   +69 more
core   +2 more sources

Compartmentalisation in cAMP signalling: A phase separation perspective

British Journal of Pharmacology, EarlyView.
Cells rely on precise spatiotemporal control of signalling pathways to ensure functional specificity. The compartmentalisation of cyclic AMP (cAMP) and protein kinase A (PKA) signalling enables distinct cellular responses within a crowded cytoplasmic space.
Milda Folkmanaite, Manuela Zaccolo
wiley   +1 more source

Necroptosis and autophagy in cisplatinum-triggered nephrotoxicity: Novel insights regarding their prognostic and diagnostic potential

Toxicology Reports
Necroptosis is an innovative class of programmed autophagy (Atg) and necrosis; considered as a type of homeostatic housekeeping machinery that have observed an escalating concern due to its power in alleviating Cisplatinum-induced nephrotoxicity.
Mai O. Kadry, Rehab M. Abdel-Megeed
doaj   +1 more source

M.tb-Rv2462c of Mycobacterium tuberculosis Shows Chaperone-like Activity and Plays a Role in Stress Adaptation and Immunomodulation

Biology, 2022
Mycobacterium tuberculosis (M.tb)-encoded factors protect it against host-generated stresses and support its survival in the hostile host environment.
Masuma Khawary, Roopshali Rakshit, Aayush Bahl, Pallavi Juneja, Sashi Kant, Saurabh Pandey, Deeksha Tripathi   +6 more
doaj   +1 more source

The human FK506-binding proteins: characterization of human FKBP19 [PDF]

, 2006
Analysis of the human repertoire of the FK506-binding protein (FKBP) family of peptidyl-prolyl cis/trans isomerases has identified an expansion of genes that code for human FKBPs in the secretory pathway.
A Galat, A Galat, A Pahl, AN Fedorov, CE Patterson, CE Patterson, Colin Robinson, DA Peattie, DS Horowitz, E Lam, E Pennisi, EC Davis, EK Baker, G Fischer, G Heijne von, H Arakawa, H Inoue, Hilda Tateossian, JD Thompson, JE Kay, JE Kay, JJ Siekierka, JJ Siekierka, John E. Kay, K Ishikawa, K Nakai, KT Bush, Lucy Gettins, M Shadidy, N Kuzhandaivelu, R Ranganathan, RD Teasdale, RF Standaert, Ross A. Kinloch, S Munro, SC Nair, Stuart L. Rulten, SW Michnick, T Nakamura, T Ratajczak, TJ Pemberton, X Meng, YJ Jin, YJ Jin   +43 more
core   +2 more sources

OsFKBP20‐1b stabilizes OsUPF1 and OsUPF2 to promote the degradation of aberrant mRNAs during dehydration stress

Journal of Integrative Plant Biology, EarlyView.
The rice protein OsFKBP20‐1b protects key RNA‐surveillance factors from breakdown, so they can better eliminate defective messages. This RNA quality‐control boost reduces errors and helps plants survive drought, revealing a link between RNA control and drought tolerance.
Haemyeong Jung, Hyun Ji Park, Seung Hee Jo, Ki‐Hong Jung, Choonkyun Jung, Hye Sun Cho   +5 more
wiley   +1 more source