Results 71 to 80 of about 98,169 (229)

Genome-wide analysis of the FKBP gene family and the potential role of GhFKBP 13 in chloroplast biogenesis in upland cotton

BMC Genomics
Background In plants, FK506-binding proteins (FKBPs) have been shown to participate in various biological processes such as photosynthetic system reaction, stress response, and growth and development.
Jianguang Liu, Zhao Geng, Guiyuan Zhao, Mengzhe Li, Zetong An, Hanshuang Zhang, Yongqiang Wang   +6 more
doaj   +1 more source

Compression of Large Sets of Sequence Data Reveals Fine Diversification of Functional Profiles in Multigene Families of Proteins: A Study for Peptidyl-Prolyl cis/trans Isomerases (PPIase)

Biomolecules, 2019
In this technical note, we describe analyses of more than 15,000 sequences of FK506-binding proteins (FKBP) and cyclophilins, also known as peptidyl-prolyl cis/trans isomerases (PPIases).
Andrzej Galat
doaj   +1 more source

Identification of postsynaptic phosphatidylinositol-4,5-bisphosphate (PIP2) roles for synaptic plasticity using chemically induced dimerization [PDF]

, 2019
Phosphatidylinositol-4,5-bisphosphate (PIP2), one of the key phospholipids, directly interacts with several membrane and cytosolic proteins at neuronal plasma membranes, leading to changes in neuronal properties including the feature and surface ...
Choi, Y.-B., Jeong, M.-J., Jo, H.-J., Jung, J.H., Kaang, B.-K., Kim, J.-H., Kim, S.-J.   +6 more
core   +1 more source

Catecholaminergic polymorphic ventricular tachycardia–linked ryanodine receptor variants exhibit domain‐specific calcium leak and calmodulin affinity properties

The Journal of Physiology, EarlyView.
Abstract figure legend Catecholaminergic polymorphic ventricular tachycardia (CPVT) variants in N terminal (NTD) and central domain (CD) but not pore domain induce a pathological RyR2 conformational shift upon protein kinase A (PKA) phosphorylation, similar to that seen in heart failure (HF), calcium/calmodulin‐dependent protein kinase II (CaMKII ...
Hitoshi Uchinoumi, Xiaoqiong Dong, Ivanita Stefanon, Yi Yang, Eduardo Hertel Ribeiro, Bengt Svensson, Xander H. T. Wehrens, Takeshi Yamamoto, Razvan L. Cornea, Robyn T. Rebbeck, Masafumi Yano, Donald M. Bers   +11 more
wiley   +1 more source

Small Molecule‐Based Conditional Gene Regulation: Advances and Applications

Chemistry–Methods, Volume 6, Issue 4, April 2026.
The precise, temporal, and reversible control of gene expression using small molecule ligands is crucial for understanding complex cellular functions and is rapidly advancing the field of synthetic biology. Small molecule‐mediated conditional gene regulation has widespread applications, including bio‐manufacturing, cellular reprogramming, gene therapy,
Mohd Afaque Ansari, Riddhima Sharma, Priyanka Swami, Ambadas B. Rode   +3 more
wiley   +1 more source

Effects of Undernutrition and Obesity on Functional and Nutritional Outcomes After Ischaemic Stroke: A Hospital‐Based Study

Journal of Human Nutrition and Dietetics, Volume 39, Issue 2, April 2026.
ABSTRACT Purpose The impact of nutritional status on post‐stroke outcomes remains controversial, particularly regarding the opposing effects of undernutrition and obesity on recovery. This study investigated how these nutritional conditions influence functional and nutritional outcomes among hospitalized ischaemic stroke survivors.
Daniela Figueiredo Corrêa Pereira, Karen Barros Parron Fernandes, Andreo Fernando Aguiar, Sergio Marques Borghi, Kamila Grandolfi, Juliano Casonatto   +5 more
wiley   +1 more source

FKBP5 associated CD8 T cell infiltration is a novel prognostic biomarker in luminal B breast cancer

Journal of International Medical Research, 2023
Objective To investigate the relationship between FKBP prolyl isomerase 5 ( FKBP5 ) gene expression and CD8 T cells in tumour progression and immunology of the luminal B subtype of breast cancer (LBBC) using bioinformatics analyses.
Fei Tong, Genlin Lu, Jie Zang, Dingji Hao, Wangjue Xu, Jida Chen, Qiong Ding, Hanchu Xiong   +7 more
doaj   +1 more source

“NEW ROUTES FOR RISK STRATIFICATION OF PATIENTS WITH HPV-NEGATIVE ORAL SQUAMOUS CELL CARCINOMA – EXPLORING THE TUMOR-MICROENVIRONMENT INTERFACE” [PDF]

, 2017
Head and Neck Cancers (HNCs) comprise a wide range of neoplasms originating from the lining epithelium of head and neck district, mainly squamous cell carcinomas of the oral cavity (OSCC).
Russo, Daniela
core   +1 more source

FKBP immunophilins and Alzheimer’s disease: A chaperoned affair

Journal of Biosciences, 2011
The FK506-binding protein (FKBP) family of immunophilins consists of proteins with a variety of protein-protein interaction domains and versatile cellular functions. Analysis of the functions of immunophilins has been the focus of studies in recent years and has led to the identification of various molecular pathways in which FKBPs play an active role.
Weihuan, Cao, Mary, Konsolaki
openaire   +2 more sources

Biochemical Engineering Perspective on cGAS: From Enzyme Discovery to Potential Industrial Application

ChemBioChem, Volume 27, Issue 5, 13 March 2026.
This review examines the structural and enzymatic properties of cyclic GMP‐AMP synthase, including substrate promiscuity, homologs, and engineered variants. In addition, it evaluates potential expression systems for large‐scale enzyme production and analyzes reaction and purification strategies for the synthesis of cyclic dinucleotides to connect ...
Makram Fataeri, Katrin Rosenthal
wiley   +1 more source