Results 81 to 90 of about 98,169 (229)
Effects of rapamycin on cultured hepatocyte proliferation and gene expression [PDF]
, 1992 Rapamycin, a potent immunosuppressive drug that disrupts normal signal‐transduction processes, inhibited hepatocyte proliferation without evidence of inherent cytotoxicity in rat hepatocytes cultured in conventional medium or in a medium enriched with ...
Azzarone, A +5 more
core +1 more source
Advanced Science, Volume 13, Issue 14, 9 March 2026.Cytokine‐engineered CAR‐T cells represent a promising immunotherapy against malignancies due to direct tumor killing and potent immunity response. However, significant toxicities, including CRS and ICANS, have restricted clinical applications. How to keep the risk‐benefit balance of the advanced therapy is of great importance for maximizing the benefit
Xinru Zhang +7 more
wiley +1 more source
Programming Next‐Generation Synthetic Biosensors by Genetic Circuit Design
Advanced Science, Volume 13, Issue 14, 9 March 2026.Synthetic biology enables genetic circuit‐based biosensing to detect diverse targets, process signals, and transduce them into readable outputs or intracellular regulatory activities. However, field deployment and real‐world application of such synthetic biosensors face considerable challenges in sensitivity, specificity, speed, stability, and ...
Yuanli Gao +4 more
wiley +1 more source
Frontiers in Pharmacology, 2018 Rapamycin (Rapa) is a highly potent drug; however, its clinical potential is limited by poor solubility, bioavailability, and cytotoxicity. To improve Rapa delivery, our team has fused the cognate protein receptor for Rapa, FKBP12, to high molecular ...
Santosh Peddi +4 more
doaj +1 more source
APP family member dimeric complexes are formed predominantly in synaptic compartments
Cell & Bioscience, 2023 Background The amyloid precursor protein (APP), a key player in Alzheimer’s disease (AD), is part of a larger gene family, including the APP like proteins APLP1 and APLP2.
Sandra Schilling +10 more
doaj +1 more source
Flipping the Switch: Next‐Generation Chemo‐Optogenetics for Reversible Control of Biological Systems
ChemPhotoChem, Volume 10, Issue 3, March 2026.Next‐generation chemo‐optogenetic systems use photoswitchable molecular glues for reversible, repeatable light control of protein proximity, enabling precise spatiotemporal modulation of signaling, organelle dynamics, and protein stability—opening avenues for in vivo studies and therapeutic applications.
Laura K. Herzog, Jun Zhang, Yao‐Wen Wu
wiley +1 more source
Ecology and Evolution, Volume 16, Issue 3, March 2026.ABSTRACT Global environmental change affects organisms, including their physiology. In freshwater ecosystems, where migration is limited, populations often rely on phenotypic plasticity to respond. While transcriptomics has been widely used to study stress responses at the molecular level, less is known about the proteome, which reflects post ...
João M. Moreno +5 more
wiley +1 more source
BMC Plant Biology, 2010 Background FK506 binding proteins (FKBPs) and cyclophilins (CYPs) are abundant and ubiquitous proteins belonging to the peptidyl-prolyl cis/trans isomerase (PPIase) superfamily, which regulate much of metabolism through a chaperone or an isomerization of
Luan Sheng +9 more
doaj +1 more source
Parasites & Vectors, 2020 Background Various transcription factors are involved in the process of mutually exclusive expression and clonal variation of the Plasmodium multigene (var) family. Recent studies revealed that a P.
Wei-Feng Wang, Yi-Long Zhang
doaj +1 more source
Plant chemical genetics : from phenotype-based screens to synthetic biology [PDF]
, 2017 The treatment of a biological system with small molecules to specifically perturb cellular functions is commonly referred to as chemical biology. Small molecules are used commercially as drugs, herbicides, and fungicides in different systems, but in ...
Dejonghe, Wim, Russinova, Eugenia
core +3 more sources