Results 181 to 190 of about 4,417 (197)

Presence of L701 M mutation in the FKS1 gene of echinocandin-susceptible Candida krusei isolates.

Diagnostic Microbiology and Infectious Disease, 2018
Resistance of Candida krusei isolates to echinocandins, the recommended drugs to treat candidemia, has been associated with mutations in hot spot (HS) regions of the FKS1 gene or L701 M mutation in a region between HS1 and HS3 of FKS1.
F. Lallitto, A. Prigitano, F. Mangione, A. Piralla, F. Tamarozzi, P. Marone, C. Cavanna   +6 more
semanticscholar   +4 more sources

Detection of Mutated erg11 and fks1 Genes among Resistant Candida Species Isolated in Pregnant Women in Mbarara, Uganda

International STD Research & Reviews
Background:  Vulvovaginal candidiasis is estimated to range between 35-60% among pregnant women worldwide. The emergency of anti-fungal resistance in Candida species against azoles and caspofungin is a rising concern because there is a limited range of ...
Nalumaga Pauline Petra, James Kiguli Mukasa, Benson Musinguzi, Jude Collins Busingye, Daniel Wambua Muasya, Israel Kiiza Njovu, Abraham Birungi, K. Kassaza, J. Bazira, Herbert Itabangi   +9 more
semanticscholar   +2 more sources

Genetic Mutations in FKS1 Gene Associated with Acquired Echinocandin Resistance in Candida parapsilosis Complex

Mycopathologia
Candida parapsilosis complex has recently received special attention due to naturally occurring FKS1 polymorphism associated with high minimal inhibitory concentrations for echinocandin and the increase of clonal outbreaks of strains resistant to commonly used antifungals such as fluconazole. Despite the previous fact, little is known about the genetic
H. Khalifa, Akira Watanabe, Katsuhiko Kamei   +2 more
semanticscholar   +3 more sources

Mutational and topological analysis of Fks1

Echinocandins represent a new antifungal group with potent activity against most Candida and Aspergillus species. These lipopeptides inhibit synthesis of [beta]-1,3-glucan, a major cell wall polysaccharide. Rare acquired resistance is associated with mutations in two "hotspot" regions of Fks1 or Fks2, the probable [beta]-1,3-glucan syntheses. Intrinsic
Michael E. Johnson
semanticscholar   +2 more sources

Molecular characterisation of Candida auris isolates from immunocompromised patients in a tertiary‐care hospital in Kuwait reveals a novel mutation in FKS1 conferring reduced susceptibility to echinocandins

Mycoses (Berlin), 2021
Candida auris is an emerging, potentially multidrug‐resistant pathogen that exhibits clade‐specific resistance to fluconazole and also develops resistance to echinocandins and amphotericin B easily. This study analysed 49 C auris isolates for alterations
M. Asadzadeh, E. Mokaddas, Suhail Ahmad, A. Abdullah, Theun de Groot, J. Meis, Shama A Shetty   +6 more
semanticscholar   +1 more source

Green synthesis of selenium nanoparticles and evaluate their effect on the expression of ERG3, ERG11 and FKS1 antifungal resistance genes in Candida albicans and Candida glabrata

Letters in Applied Microbiology, 2022
Drug resistance in Candida species has been considerably increased in the last decades. Given the opposition to antifungal agents, toxicity and interactions of the antimicrobial drugs, identifying new antifungal agents seems essential.
Mahdi Hosseini Bafghi, H. Zarrinfar, M. Darroudi, M. Zargar, R. Nazari   +4 more
semanticscholar   +1 more source

[Overexpression of FKS1 to improve yeast autolysis-stress].

Sheng wu gong cheng xue bao = Chinese journal of biotechnology, 2016
With the development of high gravity brewing, yeast cells are exposed to multiple brewing-associated stresses, such as increased osmotic pressure, enhanced alcohol concentration and nutritional imbalance. These will speed up yeast autolysis, which seriously influence beer flavor and quality. To increase yeast anti-autolytic ability, FKS1 overexpression
Jia, Li, Jinjing, Wang, Qi, Li
openaire   +1 more source

RNA-Seq analysis of global transcriptomic changes suggests a roles for the MAPK pathway and carbon metabolism in cell wall maintenance in a Saccharomyces cerevisiae FKS1 mutant.

Biochemical and Biophysical Research Communications - BBRC, 2018
FKS1 encodes a β-1,3-glucan synthase, which is a key player in cell wall assembly in Saccharomyces cerevisiae. Here we analyzed the global transcriptomic changes in the FKS1 mutant to establish a correlation between the changes in the cell wall of the ...
Cong Huang, Fengguang Zhao, Ying-Wu Lin, Suiping Zheng, Shuli Liang, Shuangyan Han   +5 more
semanticscholar   +1 more source

A putative plant homolog of the yeast β-1,3-glucan synthase subunit FKS1 from cotton (Gossypium hirsutum L.) fibers

Planta, 2001
A novel plant gene CFL1 was cloned from cotton (Gossypium hirsutum L.) fibers by expressed sequence tag (EST) database searching and 5'-RACE (rapid amplification of cDNA ends). This gene shows sequence homology with FKS1 which has been identified as the putative catalytic subunit of the yeast beta-1,3-glucan synthase.
X, Cui, H, Shin, C, Song, W, Laosinchai, Y, Amano, R M, Brown   +5 more
openaire   +2 more sources

Acquired echinocandin resistance in a Candida krusei blood isolate confirmed by mutations in the fks1 gene.

The new microbiologica, 2014
We describe a case of bloodstream infection caused by a Candida krusei strain that developed echinocandin resistance during caspofungin therapy. Three mutations were found in the HS1 region of the fks1 gene, two of them have never been reported either in C. krusei nor in C. albicans.
A.C.M. Prigitano, M.C. Esposto, M. Cogliati, L. Pitzurra, C. Santamaria, A.M. Tortorano   +5 more
openaire   +2 more sources