Results 171 to 180 of about 3,923 (195)

In vitro evolution of caspofungin resistance in Candidozyma auris via FKS1 hotspot I mutations results in moderate fitness trade-offs but no reduction in virulence

Ross ZK, Alsayegh S, Zhao Y, Munro CA, Lorenz A.   +4 more
europepmc   +1 more source

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Structural and mechanistic insights into fungal β-1,3-glucan synthase FKS1

Nature, 2023
The membrane-integrated synthase FKS is involved in the biosynthesis of β-1,3-glucan, the core component of the fungal cell wall1,2. FKS is the target of widely prescribed antifungal drugs, including echinocandin and ibrexafungerp3,4. Unfortunately, the mechanism of action of FKS remains enigmatic and this has hampered development of more effective ...
Min Zhang, Xiaotian Liu, Hongjun Yu
exaly   +3 more sources

Fitness and Virulence Costs of Candida albicans FKS1 Hot Spot Mutations Associated With Echinocandin Resistance [PDF]

Journal of Infectious Diseases, 2011
The identification of FKS1 mutations in Candida albicans associated with echinocandin resistance has raised concerns over the spread of drug-resistant strains. We studied the impact of fks1 mutations on C. albicans virulence and fitness. Compared with wild-type strains for FKS1, echinocandin-resistant C.
Ronen Ben-Ami, Guillermo Garcia-Effron, Russell E. Lewis   +2 more
exaly   +5 more sources

Targeting Fks1 proteins for novel antifungal drug discovery

Trends in Pharmacological Sciences
Fungal infections are a major threat to human health. The limited availability of antifungal drugs, the emergence of drug resistance, and a growing susceptible population highlight the critical need for novel antifungal agents. The enzymes involved in fungal cell wall synthesis offer potential targets for antifungal drug development.
Ge-Fei Hao
exaly   +3 more sources

Echinocandin Resistance in Candida auris Occurs in the Murine Gastrointestinal Tract Due to FKS1 Mutations

Antimicrobial Agents and Chemotherapy, 2023
Candida auris is resistant to multiple antifungal agents. This study investigated its antifungal susceptibility and explored FKS1 mutations across the isolates from mice enterically colonized with wild-type C. auris and treated with echinocandin.
Tatsuro Hirayama, Taiga Miyazaki, Makoto Sumiyoshi, Yuya Ito, Nobuyuki Ashizawa, Kazuaki Takeda, Naoki Iwanaga, Takahiro Takazono, Kazuko Yamamoto, Koichi Izumikawa, Katsunori Yanagihara, Koichi Makimura, Kazuhiro Tsukamoto, Shigeru Kohno, Hiroshi Mukae   +14 more
openaire   +2 more sources

The Paradoxical Effect of Echinocandins in Aspergillus fumigatus Relies on Recovery of the β-1,3-Glucan Synthase Fks1 [PDF]

Antimicrobial Agents and Chemotherapy, 2017
ABSTRACTEchinocandins target the fungal cell wall by inhibiting biosynthesis of the cell wall carbohydrate β-1,3-glucan. This antifungal drug class exhibits a paradoxical effect that is characterized by the resumption of growth of otherwise susceptible strains at higher drug concentrations (approximately 4 to 32 μg/ml). The nature of this phenomenon is
Johannes Wagener
exaly   +3 more sources

Presence of L701 M mutation in the FKS1 gene of echinocandin-susceptible Candida krusei isolates

Diagnostic Microbiology and Infectious Disease, 2018
Resistance of Candida krusei isolates to echinocandins, the recommended drugs to treat candidemia, has been associated with mutations in hot spot (HS) regions of the FKS1 gene or L701 M mutation in a region between HS1 and HS3 of FKS1. However, the role of L701 M mutation alone in causing reduced echinocandins susceptibility is still unclear.
F. Lallitto, A. Prigitano, F. Mangione, A. Piralla, F. Tamarozzi, P. Marone, C. Cavanna   +6 more
openaire   +3 more sources

Analysis of fks1 and fks2 gene mutations in invasive Candida glabrata strains from Pakistan

Mycoses, 2022
AbstractIntroductionThe gradual increase in caspofungin usage in Pakistan raises a concern of emergence of echinocandin resistance in local Candida glabrata strains. We sequenced and determined mutations in fks1 and fks2 genes in invasive Candida glabrata strains from Pakistan.Material and MethodsThirty‐six invasive C.
Saba Memon, Najia Karim Ghanchi, Urooj Zafar, Joveria Farooqi, Sadaf Zaka, Kauser Jabeen   +5 more
openaire   +2 more sources

[Overexpression of FKS1 to improve yeast autolysis-stress].

Sheng wu gong cheng xue bao = Chinese journal of biotechnology, 2016
With the development of high gravity brewing, yeast cells are exposed to multiple brewing-associated stresses, such as increased osmotic pressure, enhanced alcohol concentration and nutritional imbalance. These will speed up yeast autolysis, which seriously influence beer flavor and quality. To increase yeast anti-autolytic ability, FKS1 overexpression
Jia, Li, Jinjing, Wang, Qi, Li
openaire   +1 more source