Results 151 to 160 of about 2,691 (173)
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Targeting Fks1 proteins for novel antifungal drug discovery
Trends in Pharmacological SciencesFungal infections are a major threat to human health. The limited availability of antifungal drugs, the emergence of drug resistance, and a growing susceptible population highlight the critical need for novel antifungal agents. The enzymes involved in fungal cell wall synthesis offer potential targets for antifungal drug development.
Ge-Fei Hao
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The Paradoxical Effect of Echinocandins in Aspergillus fumigatus Relies on Recovery of the β-1,3-Glucan Synthase Fks1 [PDF]
Antimicrobial Agents and Chemotherapy, 2017 ABSTRACTEchinocandins target the fungal cell wall by inhibiting biosynthesis of the cell wall carbohydrate β-1,3-glucan. This antifungal drug class exhibits a paradoxical effect that is characterized by the resumption of growth of otherwise susceptible strains at higher drug concentrations (approximately 4 to 32 μg/ml). The nature of this phenomenon is
Johannes Wagener
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Mycopathologia
Candida parapsilosis complex has recently received special attention due to naturally occurring FKS1 polymorphism associated with high minimal inhibitory concentrations for echinocandin and the increase of clonal outbreaks of strains resistant to commonly used antifungals such as fluconazole. Despite the previous fact, little is known about the genetic
Hazim Khalifa +2 more
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Candida parapsilosis complex has recently received special attention due to naturally occurring FKS1 polymorphism associated with high minimal inhibitory concentrations for echinocandin and the increase of clonal outbreaks of strains resistant to commonly used antifungals such as fluconazole. Despite the previous fact, little is known about the genetic
Hazim Khalifa +2 more
exaly +3 more sources
Mutational and topological analysis of Fks1
Echinocandins represent a new antifungal group with potent activity against most Candida and Aspergillus species. These lipopeptides inhibit synthesis of [beta]-1,3-glucan, a major cell wall polysaccharide. Rare acquired resistance is associated with mutations in two "hotspot" regions of Fks1 or Fks2, the probable [beta]-1,3-glucan syntheses. IntrinsicMichael E. Johnson, Thomas D. Edlind
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Analysis of fks1 and fks2 gene mutations in invasive Candida glabrata strains from Pakistan
Mycoses, 2022AbstractIntroductionThe gradual increase in caspofungin usage in Pakistan raises a concern of emergence of echinocandin resistance in local Candida glabrata strains. We sequenced and determined mutations in fks1 and fks2 genes in invasive Candida glabrata strains from Pakistan.Material and MethodsThirty‐six invasive C.
Saba Memon +5 more
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[Overexpression of FKS1 to improve yeast autolysis-stress].
Sheng wu gong cheng xue bao = Chinese journal of biotechnology, 2016With the development of high gravity brewing, yeast cells are exposed to multiple brewing-associated stresses, such as increased osmotic pressure, enhanced alcohol concentration and nutritional imbalance. These will speed up yeast autolysis, which seriously influence beer flavor and quality. To increase yeast anti-autolytic ability, FKS1 overexpression
Jia, Li, Jinjing, Wang, Qi, Li
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European Journal of Clinical Microbiology & Infectious Diseases, 2014
Candida glabrata has emerged as a major pathogen in invasive candidiasis in recent years. Currently, guidelines for invasive candidiasis treatment recommend fluconazole or an echinocandin as the first-line therapy. Nevertheless, the resistance of Candida glabrata to echinocandin is an emerging problem and has been partly associated with mutations in ...
N, Bourgeois +6 more
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Candida glabrata has emerged as a major pathogen in invasive candidiasis in recent years. Currently, guidelines for invasive candidiasis treatment recommend fluconazole or an echinocandin as the first-line therapy. Nevertheless, the resistance of Candida glabrata to echinocandin is an emerging problem and has been partly associated with mutations in ...
N, Bourgeois +6 more
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Susceptibilidade de Candida albicans à Caspofungina e mutações de FKS1
2012A incidência e a prevalência de infecções fúngicas invasivas com comprometimento de vida são um grave problema de saúde humana e, não obstante dos tratamentos antifúngicos agressivos bem estabelecidos ou com novos fármacos, estas infecções são uma causa importante de morbilidade e mortalidade, especialmente em indivíduos imunocomprometidos.
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