Results 1 to 10 of about 23,726 (164)

Length-dependent disassembly maintains four different flagellar lengths in Giardia [PDF]

eLife, 2019
With eight flagella of four different lengths, the parasitic protist Giardia is an ideal model to evaluate flagellar assembly and length regulation. To determine how four different flagellar lengths are maintained, we used live-cell quantitative imaging ...
Shane G McInally, Jane Kondev, Scott C Dawson   +2 more
doaj   +4 more sources

Testing the ion-current model for flagellar length sensing and IFT regulation

eLife, 2023
Eukaryotic cilia and flagella are microtubule-based organelles whose relatively simple shape makes them ideal for investigating the fundamental question of organelle size regulation.
Hiroaki Ishikawa, Jeremy Moore, Dennis R Diener, Markus Delling, Wallace F Marshall   +4 more
doaj   +6 more sources

Analysis of biological noise in the flagellar length control system

iScience, 2021
Summary: Any proposed mechanism for organelle size control should be able to account not only for average size but also for the variation in size.
David Bauer, Hiroaki Ishikawa, Kimberly A. Wemmer, Nathan L. Hendel, Jane Kondev, Wallace F. Marshall   +5 more
doaj   +1 more source

Regulation of flagellar length in Chlamydomonas [PDF]

Seminars in Cell & Developmental Biology, 2008
Chlamydomonas reinhardtii has two apically localized flagella that are maintained at an equal and appropriate length. Assembly and maintenance of flagella requires a microtubule-based transport system known as intraflagellar transport (IFT). During IFT, proteins destined for incorporation into or removal from a flagellum are carried along doublet ...
Nedra F, Wilson, Janaki Kannan, Iyer, Julie A, Buchheim, William, Meek   +3 more
openaire   +2 more sources

A Novel MAP Kinase Regulates Flagellar Length in Chlamydomonas [PDF]

Current Biology, 2003
Little is known about the molecular basis of organelle size control in eukaryotes. Cells of the biflagellate alga Chlamydomonas reinhardtii actively maintain their flagella at a precise length. Chlamydomonas mutants that lose control of flagellar length have been isolated and used to demonstrate that a dynamic process keeps flagella at an appropriate ...
Berman, Steven A., Wilson, Nedra F., Haas, Nancy A., Lefebvre, Paul A.   +3 more
openaire   +2 more sources

FliK regulates flagellar hook length as an internal ruler [PDF]

Molecular Microbiology, 2007
Summary The mechanism of length control of the flagellar hook is under debate between two theories. One claims that the FliK directly measures the hook length as a molecular ruler, while the other claims that the cytoplasmic substructure measures the amount of hook subunits to determine the hook length. Both agree
Satoshi, Shibata, Noriko, Takahashi, Fabienne F V, Chevance, Joyce E, Karlinsey, Kelly T, Hughes, Shin-Ichi, Aizawa   +5 more
openaire   +2 more sources

Defects in the cytoplasmic assembly of axonemal dynein arms cause morphological abnormalities and dysmotility in sperm cells leading to male infertility.

PLoS Genetics, 2021
Axonemal protein complexes, such as outer (ODA) and inner (IDA) dynein arms, are responsible for the generation and regulation of flagellar and ciliary beating.
Isabella Aprea, Johanna Raidt, Inga Marlena Höben, Niki Tomas Loges, Tabea Nöthe-Menchen, Petra Pennekamp, Heike Olbrich, Thomas Kaiser, Luisa Biebach, Frank Tüttelmann, Judit Horvath, Maria Schubert, Claudia Krallmann, Sabine Kliesch, Heymut Omran   +14 more
doaj   +1 more source

Interacting Protein Kinases Involved in the Regulation of Flagellar Length [PDF]

Molecular Biology of the Cell, 2006
A striking difference of the life stages of the protozoan parasite Leishmania is a long flagellum in the insect stage promastigotes and a rudimentary organelle in the mammalian amastigotes. LmxMKK, a mitogen-activated protein (MAP) kinase kinase from Leishmania mexicana, is required for growth of a full-length flagellum.
Erdmann, M., Scholz, M., Melzer, I.M., Schmetz, C., Wiese, M.   +4 more
openaire   +4 more sources

Defective flagellar assembly and length regulation in LF3 null mutants in Chlamydomonas [PDF]

The Journal of Cell Biology, 2003
Four long-flagella (LF) genes are important for flagellar length control in Chlamydomonas reinhardtii. Here, we characterize two new null lf3 mutants whose phenotypes are different from previously identified lf3 mutants. These null mutants have unequal-length flagella that assemble more slowly than wild-type flagella, though their flagella can also ...
Tam, Lai-Wa, Dentler, William L., Jr, Lefebvre, Paul A.   +2 more
openaire   +3 more sources

Regulation of flagellar assembly and length in Chlamydomonas by LF4, a MAPK‐related kinase [PDF]

The FASEB Journal, 2019
ABSTRACT Members of the MAPK superfamily are known as key regulators of ciliogenesis. Long flagellar (LF) 4, a MAPK‐related kinase in Chlamydomonas , is the first kinase that was implicated in ciliary assembly and length.
Yingrui, Wang, Yahui, Ren, Junmin, Pan
openaire   +2 more sources