Results 131 to 140 of about 61,644 (304)

Vaccine Adjuvants in the Immunocompromised Host: Science, Safety, and Efficacy

Transplant Infectious Disease, EarlyView.
ABSTRACT Vaccine adjuvants are essential for enhancing immune responses to vaccines, particularly in immunocompromised populations who typically demonstrate suboptimal responses to standard vaccination. This narrative review evaluates the safety and efficacy of approved and candidate adjuvants in immunocompromised hosts, with emphasis on solid organ ...
Haya Hayek, Lana Hasan, Justin Z. Amarin, Yasmeen Z. Qwaider, Olla Hamdan, Wanderson Rezende, Kevin C. Dee, James D. Chappell, Natasha B. Halasa   +8 more
wiley   +1 more source

CD2-1, the C-Terminal Region of Flagellin, Modulates the Induction of Immune Responses in Rice

Molecular Plant-Microbe Interactions, 2015
Flagellin from the rice avirulent N1141 strain of Acidovorax avenae functions as a pathogen-associated molecular pattern (PAMP) and induces PAMP-triggered immunity (PTI) in rice.
Yuya Katsuragi, Ryota Takai, Takehito Furukawa, Hiroyuki Hirai, Takumi Morimoto, Takara Katayama, Takahiko Murakami, Fang-Sik Che   +7 more
doaj   +1 more source

Toxoplasma gondii profilin does not stimulate an innate immune response through bovine or human TLR5 [PDF]

Toxoplasma gondii is responsible for one of the most prevalent infections in people. T. gondii profilin (TgPr) is a protein integral to parasite movement and cellular invasion. Murine TLR has been described to bind TgPr. Furthermore, more recently, human
Burgess, G, Holder, A L, Tombacz, K, Werling, D, Werners, A   +4 more
core   +1 more source

Structural basis for specific flagellin recognition by the NLR protein NAIP5

Cell Research, 2017
The nucleotide-binding domain- and leucine-rich repeat (LRR)-containing proteins (NLRs) function as intracellular immune receptors to detect the presence of pathogen- or host-derived signals. The mechanisms of how NLRs sense their ligands remain elusive.
Xinru Yang, Fan Yang, Weiguang Wang, G. Lin, Zehan Hu, Zhifu Han, Y. Qi, Liman Zhang, Jiawei Wang, S. Sui, J. Chai   +10 more
semanticscholar   +1 more source

Decoding Long‐Distance Communication Under Mineral Stress: Advances in Vascular Signalling and Molecular Tools for Plant Resilience

Plant, Cell &Environment, Volume 48, Issue 7, Page 4781-4802, July 2025.
ABSTRACT Mineral nutrients are essential for plant growth, development and crop yield. Under mineral deficient conditions, plants rely on a sophisticated network of signalling pathways to coordinate their molecular, physiological, and morphological responses.
Chao Xia, Juliana Miranda, David Mendoza‐Cozatl, Byung‐Kook Ham, Jianxin Ma, Cankui Zhang   +5 more
wiley   +1 more source

Multiple Flagellin Proteins Have Distinct and Synergistic Roles in Agrobacterium tumefaciens Motility

bioRxiv, 2018
Flagellins are abundant bacterial proteins comprising the flagellar filaments that propel bacterial movement. Several members of the alphaproteobacterial group express multiple flagellins, in contrast to model systems, such as with Escherichia coli ...
Bitan Mohari, Melene A Thompson, J. Trinidad, S. Setayeshgar, C. Fuqua   +4 more
semanticscholar   +1 more source

Single‐microbe RNA sequencing uncovers unexplored specialized metabolic functions of keystone species in the human gut

iMeta, Volume 4, Issue 3, June 2025.
The human body is inhabited by trillions of microorganisms that play a crucial role in health and diseases. Although our understanding of the species and functional composition of the human gut microbiome is rapidly expanding, species–function heterogeneity and dynamic activities in human microecosystem niches remain unclear.
Yifei Shen, Wenxin Qu, Mengdi Song, Tianyu Zhang, Chang Liu, Xiaofeng Shi, Xinxin Xu, Jingjing Jiang, Liguo Ding, Fangyu Mo, Zheying Mao, Mingzhu Huang, Ziye Xu, Jiaye Chen, Enhui Shen, Jian Ruan, Jiong Liu, Michael P. Timko, Yu Chen, Longjiang Fan, Shufa Zheng, Yongcheng Wang   +21 more
wiley   +1 more source

Molecular mechanisms of autoimmunity triggered by microbial infection [PDF]

, 2005
Autoimmunity can be triggered by microbial infection. In this context, the discovery of Toll-like receptors (TLRs) provides new insights and research perspectives.
Anders, Hans-Joachim, Patole, Prashant S, Pawar, Rahul D, Zecher, Daniel   +3 more
core   +2 more sources

Signatures of antagonistic pleiotropy in a bacterial flagellin epitope.

Cell Host and Microbe, 2021
Katarzyna Parys, Nicholas R. Colaianni, Ho-Seok Lee, U. Hohmann, Natalie Edelbacher, Alen Trgovcevic, Zuzana Blahovska, Du-Hwa Lee, Alexander Mechtler, Zsuzsanna Muhari-Portik, M. Madalinski, Niklas Schandry, Isaac Rodríguez-Arévalo, C. Becker, E. Sonnleitner, A. Korte, U. Bläsi, N. Geldner, M. Hothorn, Corbin D. Jones, J. Dangl, Youssef Belkhadir   +21 more
semanticscholar   +1 more source

Discovery of a proteolytic flagellin family in diverse bacterial phyla that assembles enzymatically active flagella

Nature Communications, 2017
Bacterial flagella are cell locomotion and occasional adhesion organelles composed primarily of the polymeric protein flagellin, but to date have not been associated with any enzymatic function.
U. Eckhard, Hina Bandukwala, Michael J. Mansfield, G. Marino, Jiujun Cheng, IainDavid Wallace, T. Holyoak, Trevor C. Charles, J. Austin, C. Overall, A. Doxey   +10 more
semanticscholar   +1 more source