Results 11 to 20 of about 58,715 (277)
FliS/flagellin/FliW heterotrimer couples type III secretion and flagellin homeostasis [PDF]
Scientific Reports, 2018 Flagellin is amongst the most abundant proteins in flagellated bacterial species and constitutes the major building block of the flagellar filament. The proteins FliW and FliS serve in the post-transcriptional control of flagellin and guide the protein ...
Florian Altegoer +6 more
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Flagellin as a vaccine adjuvant
Expert Review of Vaccines, 2018 Introduction: Bacterial flagellin, as a pathogen-associated molecular pattern (PAMP), can activate both innate and adaptive immunity. Its unique structural characteristics endow an effective and flexible adjuvant activity, which allow the design of ...
Baofeng Cui +5 more
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Microbiology Research, 2010 Yersinia enterocolitica strain 8081, representing the high-pathogenic biotype 1B, harbours three flagellin genes arranged in tandem in the order fliC3, fliC, fliC2. The genes are organized monocistronic but coordinately expressed under the control of the
Daniela Lepka, Gottfried Wilharm
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Structural basis for flagellin induced NAIP5 activation [PDF]
Science Advances, 2023 SummaryThe NAIP/NLRC4 inflammasome is activated when NAIP binds to a gram-negative bacterial ligand. Initially, NAIP exists in an inactive state with a wide-open conformation. Upon ligand binding, the winged helix domain (WHD) of NAIP is activated and forms steric clash with NLRC4 to open it up.
Bhaskar Paidimuddala +2 more
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Journal of Bacteriology, 1977 Flagellins from 17 Caulobacter strains were partially purified. Their molecular weights and immunological properties indicated that a two-component flagellin system is common among Caulobacters.
Carl F. Lagenaur, Nina Agabian
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Isolation and characterization of Campylobacter flagellins [PDF]
Journal of Bacteriology, 1987 Sequential acid pH dissociation, differential ultracentrifugation, and neutral pH reassociation were used to partially purify serotypically distinct flagella from three strains of Campylobacter jejuni and the two antigenic phases of flagella of Campylobacter coli VC167. Each C. jejuni flagellin and C.
Susan M. Logan +2 more
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Luminal-applied flagellin is internalized by polarized intestinal epithelial cells and elicits immune responses via the TLR5 dependent mechanism. [PDF]
PLoS ONE, 2011 Bacteria release flagellin that elicits innate responses via Toll-like receptor 5 (TLR5). Here, we investigated the fate of apically administrated full length flagellin from virulent and avirulent bacteria, along with truncated recombinant flagellin ...
Tonyia Eaves-Pyles +6 more
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Intraluminal Flagellin Differentially Contributes to Gut Dysbiosis and Systemic Inflammation following Burn Injury. [PDF]
PLoS ONE, 2016 Burn injury is associated with a loss of gut barrier function, resulting in systemic dissemination of gut-derived bacteria and their products. The bacterial protein and TLR5 agonist, flagellin, induces non-specific innate immune responses.
Logan Grimes +7 more
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Cell Reports, 2023 Summary: Unidirectional growth of filamentous protein assemblies including the bacterial flagellum relies on dedicated polymerization factors (PFs). The molecular determinants and structural transitions imposed by PFs on multi-subunit assembly are poorly
Nicolas Kint, Patrick H. Viollier
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mTORC1 Regulates Flagellin-Induced Inflammatory Response in Macrophages. [PDF]
PLoS ONE, 2015 Bacterial flagellin triggers inflammatory responses. Phosphoinositide 3-kinase (PI3K) and mammalian target of rapamycin (mTOR) regulate the production of pro- and anti-inflammatory cytokines that are induced by extrinsic antigens, but the function of ...
Wenlei Bao +8 more
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