Nature Communications, 2019 Alterations in gut microbiota composition are associated with metabolic syndrome and chronic inflammatory diseases such as inflammatory bowel disease.
H. Tran +3 more
semanticscholar +1 more source
Interaction of FliS flagellar chaperone with flagellin [PDF]
FEBS Letters, 2006 Premature polymerization of flagellin (FliC), the main component of flagellar filaments, is prevented by the FliS chaperone in the cytosol. Interaction of FliS with flagellin was characterized by isothermal titration calorimetry producing an association constant of 1.9 × 107 M−1 and a binding stoichiometry of 1:1.
Zoltán Gugolya +5 more
openaire +3 more sources
Pseudomonas evades immune recognition of flagellin in both mammals and plants.
PLoS Pathogens, 2011 The building blocks of bacterial flagella, flagellin monomers, are potent stimulators of host innate immune systems. Recognition of flagellin monomers occurs by flagellin-specific pattern-recognition receptors, such as Toll-like receptor 5 (TLR5) in ...
Bart W Bardoel +6 more
doaj +1 more source
High-Resolution Structure and Intermolecular Interactions between L-type Straight Flagellar Filaments [PDF]
, 2016 Bacterial mobility is powered by rotation of helical flagellar filaments driven by rotary motors. Flagellin isolated from {\it Salmonella Typhimurium} SJW1660 strain, which differs by a point mutation from the wild-type strain, assembles into straight filaments in which flagellin monomers are arranged into left-handed helix.
arxiv +1 more source
Understanding the dynamics of Toll-like Receptor 5 response to flagellin and its regulation by estradiol [PDF]
, 2017 © 2017 The Author(s). Toll-like receptors (TLRs) are major players of the innate immune system. Once activated, they trigger a signalling cascade that leads to NF-ΰ B translocation from the cytoplasm to the nucleus. Single cell analysis shows that NF-ΰ
B Calippe +42 more
core +4 more sources
Methylation of the Flagellin of Salmonella typhimurium [PDF]
Journal of Bacteriology, 1971 The methylation of endogenous proteins by Salmonella typhimurium SL 870 was investigated in cell-free extracts by using S -adenosylmethionine as methyl donor. Several lines of evidence are presented which suggest that one of the methylated products is the protein flagellin.
Steven R. Tronick, Rafael J. Martinez
openaire +3 more sources
Trained immunity or tolerance : opposing functional programs induced in human monocytes after engagement of various pattern recognition receptors [PDF]
, 2014 Article Accepted Date: 29 January 2014. ACKNOWLEDGMENTS D.C.I. received funding from the European Union's Seventh Framework Programme (FP7/2007-2013) under grant agreement HEALTH-2010-260338 (“Fungi in the setting of inflammation, allergy and autoimmune ...
Gow, Neil A R +9 more
core +3 more sources
Studies on the Use of Flagellin as an Immunostimulant and Vaccine Adjuvant in Fish Aquaculture
Frontiers in Immunology, 2019 Immunostimulants and vaccines are important for controlling infectious diseases in fish aquaculture. In this study we assess the potential of flagellin to be used for such purposes in rainbow trout (Oncorhynchus mykiss).
Eakapol Wangkahart +2 more
semanticscholar +1 more source
NLRC4 Inflammasome-Driven Immunogenicity of a Recombinant MVA Mucosal Vaccine Encoding Flagellin
Frontiers in Immunology, 2018 Bacterial flagellin enhances innate and adaptive immune responses and is considered a promising adjuvant for the development of vaccines against infectious diseases and cancer.
Stephanie L. Sanos +13 more
doaj +1 more source
Sea anemone model has a single Toll-like receptor that can function in pathogen detection, NF-κB signal transduction, and development [PDF]
, 2017 In organisms from insects to vertebrates, Toll-like receptors (TLRs) are primary pathogen detectors that activate downstream pathways, specifically those that direct expression of innate immune effector genes.
Brennan, Joseph J. +5 more
core +1 more source