Results 131 to 140 of about 442,397 (295)

Efficacy and Safety of Nanoencapsulated Sirolimus Plus Pegadricase: Results From the Randomized, Placebo‐Controlled Phase 3 Trials

Arthritis &Rheumatology, EarlyView.
Objective DISSOLVE I and II examined the efficacy and safety of nanoencapsulated sirolimus (NAS) plus pegadricase (NASP) in patients with uncontrolled gout (UG). Methods In these double‐blind, placebo‐controlled Phase 3 trials of NASP, patients were randomized 1:1:1 to infusions of high‐dose (HD) or low‐dose (LD) NAS plus pegadricase (HD NASP, LD NASP,
Herbert S. B. Baraf, Puja P. Khanna, Milan Petronijevic, Mamuka Lortkipanidze, Anand Patel, Kwabena Ayesu, Michael H. Pillinger, Atul Singhal, Joanna Sobierska, Jacquie Christie, Peter Traber, Rehan Azeem, Wesley DeHaan, Hugues Santin‐Janin, Bhavisha Desai, Alan Kivitz   +15 more
wiley   +1 more source

Human Monocytic Models Reveal Genotype‐Dependent Inflammatory Programs in VEXAS Syndrome

Arthritis &Rheumatology, Accepted Article.
Objectives VEXAS syndrome is a severe X‐linked autoinflammatory disorder caused by somatic mutations in ubiquitin‐like modifier activating enzyme 1 (UBA1), with clinical outcomes that vary by UBA1 genotype. We aimed to elucidate genotype‐specific inflammatory programs and identify potential therapeutic targets.
Kana Higashitani, Tatsuma Ban, Yohei Kirino, Go R Sato, Soichiro Adachi, Yuki Iizuka, Kayo Harita, Ayaka Maeda, Osamu Ohara, Hideaki Nakajima, Tomohiko Tamura   +10 more
wiley   +1 more source

Flare Stars and the Radio [PDF]

Science, 1951
openaire   +2 more sources

Combined Anterior Cruciate Ligament Reconstruction and Lateral Extra‐articular Tenodesis With Augmented Continuous Iliotibial Band Autograft

Arthroscopy Techniques, EarlyView.
Abstract The purpose of this technical note is to describe a reproducible surgical technique for anterior cruciate ligament reconstruction combined with a lateral tenodesis using a continuous iliotibial band autograft that allows self‐augmentation of graft diameter without the need for additional tendon harvesting.
Gregoire Zerr, David Eichler, Pierre Imbert, Christian Lutz   +3 more
wiley   +1 more source

Equilibria and oscillations of magnetised neutron stars

, 2010
We investigate equilibrium configurations and oscillation spectra of neutron stars,modelled as rotating magnetised fluid bodies in Newtonian gravity. We also explorethe idea that these model neutron stars could have dynamics analogous to rigid-bodyfree ...
Lander, Samuel Kenneth
core   +1 more source

Analyzing the Morphology of Late-phase Stellar Flares from G-, K-, and M-type Stars

The Astrophysical Journal
Stellar flares occasionally present a peak-bump light-curve morphology, consisting of an initial impulsive phase followed by a gradual late phase.
Denise G. Yudovich, Kai E. Yang, Xudong Sun   +2 more
doaj   +1 more source

S. aureus colonization and clinical symptoms remain stable upon topical XZ.700 treatment: Results of a double‐blind randomized clinical trial in patients with mild to moderate atopic dermatitis

British Journal of Clinical Pharmacology, EarlyView.
Aim Recovering dysbiosis may improve atopic dermatitis (AD) symptoms. XZ.700 is a recombinant chimeric endolysin that specifically targets Staphylococcus aureus and could be a new treatment option for patients with AD. The aim of this first‐in‐human study was to evaluate the safety, tolerability and efficacy of topical XZ.700 and explore the ...
Laura W. J. van der Meulen, Menthe E. Bergmans, Salma Assil, Naomi Klarenbeek, Marieke L. de Kam, Alexa J. Tibboel, Thorsten Brach, Bjorn L. Herpers, Johan Frieling, Vincent de Jong, Benthe Freyee, Martijn B. A. van Doorn, Robert Rissmann, Tessa Niemeyer–van der Kolk   +13 more
wiley   +1 more source

KIC 6464285: A Solar-type Eclipsing Binary in a Hierarchical Triple System with Quasiperiodic Out-of-eclipse Modulations

The Astrophysical Journal
We present the first detailed analysis of the solar-type triple system KIC 6464285. Combining long-term, high-precision photometry from Kepler, the Transiting Exoplanet Survey Satellite, and the Zwicky Transient Facility with low-resolution spectra from ...
Fang-Bin Meng, Li-Ying Zhu, Sheng-Bang Qian, Ildar Asfandiyarov, Azizbek Matekov, Jaqsiliq Baltamuratov, Wen-Ping Liao, A-Li Luo, Wen Hou, Ping Li, Lin-Jia Li, Er-Gang Zhao, Jia-Jia He   +12 more
doaj   +1 more source

Glucocorticoid exposure and initiation of SSRIs among patients with rheumatoid arthritis: A nested case–control study in UK primary care

British Journal of Clinical Pharmacology, EarlyView.
Aim The immune system might affect the development of anxiety disorders, though mechanisms remain unclear. This nested case–control study investigates whether use of glucocorticoids, potent immunosuppressants, is associated with SSRI initiation (a proxy for pharmacologically treated mental disorders, predominantly depression and/or anxiety).
Elise J. Heesbeen, Patrick C. Souverein, Eibert R. Heerdink, Elisabeth Y. Bijlsma, Lucianne Groenink   +4 more
wiley   +1 more source

Polarization of Circumstellar Debris Disk Light Echoes

The Astronomical Journal
Light echoes of debris disks around active stars can reveal disk structure and composition even when disks are not spatially resolved. Unfortunately, distinguishing reflected light from quiescent starlight and unexpected post-peak flare structure is ...
Austin J. King, Benjamin C. Bromley, Preston W. Harris, Scott J. Kenyon   +3 more
doaj   +1 more source