Results 131 to 140 of about 5,736 (170)

Early microglial activation in the TME enables FLASH-RT to eradicate medulloblastoma while promoting neuron-astrocyte crosstalk to minimize toxicity in the hippocampus

Knol M, Franco-Pérez J, Almeida A, Kunz LV, Petit B, Job A, Ollivier J, Romero J, Jansen J, Grilj V, Limoli C, Vozenin M, Ballesteros-Zebadúa P.   +12 more
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FLASH Radiotherapy is faster than a heartbeat: A compartmental model to illustrate the interplay between tissue oxygen perfusion and ultra-high dose rate effects

Ballesteros-Zebadua P, Jansen J, Grilj V, Franco-Perez J, Vozenin M, Abolfath R.   +5 more
europepmc   +1 more source

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Abstract P1-10-02: FLASH-RT, ultra-high dose rate rate radiotherapy, is as effective as conventional dose rate radiotherapy in eradicating tumor in a preclinical model of breast cancer

Cancer Research, 2023
Problem Statement: Radiation therapy (RT) for breast cancer (BC) can induce skin and soft tissue fibrosis, raises concerns over cardiac and pulmonary injury, is associated with higher rates of lymphedema and shoulder dysfunction with regional nodal ...
F. Dirbas, S. Melemenidis, B. Loo, K. Horst, E. Graves, S. Dutt, Vignesh Viswanathan, B. Lau, Amy S. Yu   +8 more
semanticscholar   +1 more source

Ultrahigh Dose-rate Radiotherapy: Next Steps for FLASH-RT

Clinical Cancer Research, 2018
A new way of delivering radiotherapy at very high dose rates is described and compared with conventional radiotherapy. The ultrahigh dose-rate therapy reduces damage to normal pig skin and exerts potent activity against spontaneous nasal tumors in cat ...
K. Harrington
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Effects of Ultra-High Dose-Rate Radiotherapy (FLASH-RT) on the Hematopoietic and Immune Systems: An Animal Study.

Radiation Research
Ultra-high dose-rate radiotherapy, also known as FLASH radiotherapy (FLASH-RT), reduces radiation-induced damage in several organs. This study aimed to compare the effects of FLASH-RT and conventional dose-rate radiotherapy (CONV-RT) at 3 Gy and 5 Gy of ...
Tosol Yu, Y. Yoon, Chul Won Choi, Jin-Young Kim, Y. Moon, T. Son, D. Jeong, Man-Woo Lee, Heuijin Lim, Kyoung Won Jang, Hyun Kim, Hak Jae Kim, W. Jeon, M. Choi   +13 more
semanticscholar   +1 more source

FLASH Radiotherapy: From In Vivo Data to Clinical Translation.

Hematology/Oncology Clinics of North America
Delivery of radiotherapy (RT) at ultra-high dose rates or FLASH radiotherapy (FLASH-RT) is an emerging treatment option for patients with cancer that could increase survival outcomes and quality of life.
Heather R. Manring, J. Fleming, Wei Meng, Mauricio Gamez, D. Blakaj, Arnab Chakravarti   +5 more
semanticscholar   +1 more source

Average Dose Rate is the Major Temporal Beam Structure Parameter for Preserving Murine Intestines with Pulsed Electron FLASH-RT.

International Journal of Radiation Oncology, Biology, Physics
PURPOSE The relationship between physical parameters of pulsed beams and the FLASH effect remains largely unexplored. Our research aimed to investigate systematically the beam requirements necessary for pulsed-electron FLASH radiotherapy (FLASH-RT ...
V. Grilj, A. Zayas, A. Sesink, P. Devanand, David Repáraz, Ryan Paisley, K. Sprengers, Katiuska Passelli, Julie Pernot, T. Böhlen, Reiner Geyer, R. Moeckli, C. Bailat, J. Germond, J. Dagher, F. Bochud, J. Bourhis, F. Herrera   +17 more
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Physics and biology of ultrahigh dose-rate (FLASH) radiotherapy: a topical review

Physics in Medicine and Biology, 2020
Ultrahigh dose-rate radiotherapy (RT), or ‘FLASH’ therapy, has gained significant momentum following various in vivo studies published since 2014 which have demonstrated a reduction in normal tissue toxicity and similar tumor control for FLASH-RT when ...
N. Esplen, M. Mendonca, M. Bazalova-Carter   +2 more
semanticscholar   +1 more source