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The World of Algae Reveals a Broad Variety of Cryptochrome Properties and Functions
Algae are photosynthetic eukaryotic (micro-)organisms, lacking roots, leaves, and other organs that are typical for land plants. They live in freshwater, marine, or terrestrial habitats.
Jan Petersen +6 more
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Enhanced small green fluorescent proteins as a multisensing platform for biosensor development
Engineered light, oxygen, and voltage (LOV)-based proteins are able to fluoresce without oxygen requirement due to the autocatalytic incorporation of exogenous flavin as a chromophore thus allowing for live cell imaging under hypoxic and anaerobic ...
Guo-Teng Liang +25 more
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Disruptive innovation, the episteme and technology-enhanced learning in higher education
This paper combines the theory of disruptive innovation with Foucault's concept of the episteme, in order to analyse the extent to which the integration of Foucauldian analysis clarifies understandings of disruptive innovation ...
Michael Flavin
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Flavin oxidation in flavin‐dependent N‐monooxygenases [PDF]
AbstractSiderophore A (SidA) from Aspergillus fumigatus is a flavin‐containing monooxygenase that hydroxylates ornithine (Orn) at the amino group of the side chain. Lysine (Lys) also binds to the active site of SidA; however, hydroxylation is not efficient and H2O2 is the main product.
Sobrado, Pablo +3 more
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“I kind of feel resigned to the fact”:
Social media technologies are popular and pervasive. They also entail the submission of personal data which is sold on to third parties. Users trade their personal data in return for free access to social media services.
Michael Flavin
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Microorganisms utilize electron bifurcating enzymes in metabolic pathways to carry out thermodynamically unfavorable reactions. Bifurcating FeFe-hydrogenases (HydABC) reversibly oxidize NADH (E′∼−280 mV, under physiological conditions) and reduce protons
Gerrit J. Schut +5 more
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Flavofun: Exploration of fungal flavoproteomes
Fungi produce a plethora of natural products exhibiting a fascinating diversity of chemical structures with an enormous potential for medical applications.
Bianca Kerschbaumer +2 more
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Flavin mononucleotides (FMNs) and flavin adenine nucleotide (FAD) play vital roles in the electron-transfer processes in diverse enzymatic reactions.
Yawen Liu +5 more
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Increased Yields of the Guanine Oxidative Damage Product Imidazolone Following Exposure to LED Light
Among the bases of DNA, guanine is the most easily oxidized. Imidazolone (Iz) is a guanine oxidative damage, and we sought to generate Iz-containing oligomers. In this paper, we describe the methods and conditions to increase the yield of Iz by employing
Taishu Kawada +2 more
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Most flavin-dependent enzymes contain a dissociable flavin cofactor. We present a new approach for installing a covalent bond between a flavin cofactor and its hosting protein. By using a flavin transferase and carving a flavinylation motif in target proteins, we demonstrate that ‘dissociable’ flavoproteins can be turned into covalent flavoproteins ...
Yapei Tong +5 more
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