Results 81 to 90 of about 82,939 (224)

Common pathways and outliers in glucose catabolism across Trypanosomatidae

The FEBS Journal, EarlyView.
Trypanosomatid parasites, including Trypanosoma sp., Leishmania sp., Phytomonas sp., and Vickermania sp., share a common motif: a metabolism built around the glycosome, a unique peroxisome‐derived organelle housing the first steps of glycolysis. Yet, these organisms have evolved remarkably diverse strategies to catabolize glucose, excreting distinct ...
Fred R. Opperdoes, Mayke B. Alencar, Ariel M. Silber, Ingrid Škodová‐Sveráková, Kristína Záhonová, Vyacheslav Yurchenko   +5 more
wiley   +1 more source

Dynamic Conformations of Flavin Adenine Dinucleotide:  Simulated Molecular Dynamics of the Flavin Cofactor Related to the Time-Resolved Fluorescence Characteristics

, 2016
Molecular dynamics (MD) simulations and polarized subnanosecond time-resolved flavin fluorescence spectroscopy have been used to study the conformational dynamics of the flavin adenine dinucleotide (FAD) cofactor in aqueous solution.
Alan E. Mark (535969), K. Anton Feenstra (67029), Herman J. C. Berendsen (2720605), Petra A. W. van den Berg (3051216), Antonie J. W. G. Visser (231090)   +4 more
core   +1 more source

Generation of the Camptothecin Scaffold by a Flavin‐Catalyzed Photooxidative Skeletal Reorganization

Angewandte Chemie, Volume 138, Issue 36, 1 September 2026.
The biosynthetic pathway of the anticancer drug precursor camptothecin involves an enigmatic skeletal reorganization from a 6/5/6 tetrahydro‐β‐carboline to a 6/6/5 pyrroloquinoline ring system. Here, we show that this transformation can be achieved by photooxidation with flavin cofactors, such as flavin mononucleotide (FMN) as catalysts.
Shenyu Liu, Zeliang Zhang, Benedikt Seligmann, Van Hung Bui, Tuan‐Anh Minh Nguyen, Thu‐Thuy T. Dang, Jakob Franke   +6 more
wiley   +2 more sources

Reconstitution of apo-DT-diaphorase with flavin-adenine dinucleotide.

Chemical and Pharmaceutical Bulletin, 1986
The binding of flavin-adenine dinucleotide (FAD) in DT-diaphorase was studies. Incubation with 4M guanidine-HCl at 0°C rapidly dissociated FAD from the enzyme, and incubation of the apo-enzyme with FAD at 37°C restored maximally about 50% (for menadione-reducing activity), or 330% (for ferricyanide-reducing activity) of the initial activity.
WADA, IKUO, KOGA, NOBUYUKI, YOSHIHARA, SHIN'ICHI, YOSHIMURA, HIDETOSHI   +3 more
openaire   +3 more sources

CD36‐mediated lipid rewiring in the metabolic adaptation of tumour ecosystems

The FEBS Journal, EarlyView.
Nutrient deprivation drives a lipid‐centric shift in tumour metabolic symbiosis and signalling network. CD36 functions as a bidirectional bridge, transferring fatty acids from stromal donors (adipocytes, CAFs) to the ecosystem tumour‐ and microenvironment‐dependently.
Anna Sebestyén, Viktória Varga, Fatime Szalai, Risa Miyaura, Nóra Förhécz, Bálint Csikós, Rebeka Gelencsér, Zsófia Gábriel, Timea Komlódi, Katalin Dezső, Ildikó Krencz, Dorottya Moldvai   +11 more
wiley   +1 more source

The stacked flavin adenine dinucleotide conformation in water is fluorescent on picosecond timescale.

, 2003
The fluorescence upconversion technique has been applied to examine the picosecond fluorescence decay kinetics of flavin adenine dinucleotide (FAD) in aqueous solution.
Chosrowjan, H., Tanaka, F., Mataga, N., Visser, A.J.W.G., Taniguchi, S.   +4 more
core   +1 more source

StyA1 and StyA2B from Rhodococcus opacus 1CP: a Multifunctional Styrene Monooxygenase System [PDF]

, 2010
Two-component flavoprotein monooxygenases are emerging biocatalysts that generally consist of a monooxygenase and a reductase component. Here we show that Rhodococcus opacus 1CP encodes a multifunctional enantioselective flavoprotein monooxygenase system
Groning, J.A.D., Michael Schlömann, Kaschabek, S.R., Dirk Tischler, Stefan R. Kaschabek, van Berkel, W.J.H., Tischler, D., Berkel, W.J.H., van, Willem J. H. van Berkel, René Kermer, Janosch A. D. Gröning, Schlomann, M., Kermer, R.   +12 more
core   +1 more source

Microbiome and Metabolomics in Obesity: Advances in Understanding and Interventions Across the Lifespan

Obesity Reviews, EarlyView.
ABSTRACT Obesity arises from intertwined and reciprocal diet‐microbiome‐host pathways that reshape energy balance, insulin sensitivity, and inflammation. This review synthesizes mechanistic links between microbial functions and metabolic control, charts lifestyle‐related lifecourse dynamics from birth to older age, examines how GLP‐1‐based therapies ...
Ioanna Panagiota Kalafati, David Krongauz, Alice Bosco, Antonio Noto, Cristina Piras, Maria Kafyra, Angelica Dessì, Matteo Mauri, Luigi Atzori, Adina Weinberger, Vassilios Fanos, George V. Dedoussis, on behalf of the BETTER4U consortium   +12 more
wiley   +1 more source

Two-Component FAD-Dependent Monooxygenases: Current Knowledge and Biotechnological Opportunities

Biology, 2018
Flavoprotein monooxygenases create valuable compounds that are of high interest for the chemical, pharmaceutical, and agrochemical industries, among others. Monooxygenases that use flavin as cofactor are either single- or two-component systems.
Thomas Heine, Willem J. H. van Berkel, George Gassner, Karl-Heinz van Pée, Dirk Tischler   +4 more
doaj   +1 more source

Photochemistry of CryB from Rhodobacter sphaeroides

Photochemistry and Photobiology, EarlyView.
Elucidation of the photochemistry of CryB from Rhodobacter sphaeroides was achieved from the nanosecond to second timescale. A fast (<5 ns) deprotonation of the terminal electron donor Trp338 and the involvement of Tyr337 in photoreduction have been revealed.
Christopher Einholz, Johannes Ruhnke, Jonas Diez, Andreas Günter, Johannes Berger, Stefan Weber, Erik Schleicher   +6 more
wiley   +1 more source