Results 71 to 80 of about 20,065 (197)
Non‐canonical PKG1 regulation in cardiovascular health and disease
British Journal of Pharmacology, EarlyView.It is well established that the cyclic GMP‐dependent protein kinase I (PKG1) is canonically activated by cyclic guanosine monophosphate (cGMP), enabling its regulation of vascular tone, cardiac function and smooth muscle homeostasis. However, diverse non‐canonical stimuli of PKG1 have also been identified.
Jie Su, Joseph Robert Burgoyne
wiley +1 more source
Reconstitution of Flavin-Adenine Dinucleotide in the Apoenzyme of Glucose Oxidase
THE JOURNAL OF VITAMINOLOGY, 1971 The reconstitution reaction of glucose oxidase from FAD and apoenzyme was studied:(1) Unimolecular reaction takes part in the reaction of glucose apooxidase with FAD as a rate limiting step.(2) At the very initial stage of the reaction, intensity of the fluorescence derived from FAD was observed to increase rapidly and to be quenched slowly after ...
TSUGE, HARUHITO, MITSUDA, HISATERU
openaire +3 more sources
The FEBS Journal, EarlyView.Human NAD(P)H:quinone oxidoreductase 1 is a homodimeric flavoenzyme crucial for redox metabolism and linked to significant health issues. Point mutations at Tyr126 and Tyr128 demonstrate their essential roles in optimizing substrate binding geometry for catalysis, as well as in half‐site reactivity and conformational dynamics during the enzyme's ...
Maribel Rivero +8 more
wiley +1 more source
A chemo‐enzymatic colorimetric cascade for detecting ethylene glycol contamination
The FEBS Journal, EarlyView.A chemo‐enzymatic cascade is developed for ethylene glycol (EG) detection. EG is oxidized by GoADH with C1‐mediated cofactor recycling to produce glycolaldehyde (GAL). GAL subsequently reacts with purpald to generate a detectable purple chromophore.
Tawatchai Singphongam +6 more
wiley +1 more source
Common pathways and outliers in glucose catabolism across Trypanosomatidae
The FEBS Journal, EarlyView.Trypanosomatid parasites, including Trypanosoma sp., Leishmania sp., Phytomonas sp., and Vickermania sp., share a common motif: a metabolism built around the glycosome, a unique peroxisome‐derived organelle housing the first steps of glycolysis. Yet, these organisms have evolved remarkably diverse strategies to catabolize glucose, excreting distinct ...
Fred R. Opperdoes +5 more
wiley +1 more source
Biotechnology & Biotechnological Equipment, 2018 Cytochrome P450 reductase (CPR) is an integral component of the P450 oxidoreductase system (P450s). It serves as the electron donor for most cytochromes in P450s, which are involved in the metabolism of foreign compounds and the synthesis of endocrine ...
Fanglan Ge +5 more
doaj +1 more source
Laser-Induced Fluorescence Spectroscopy in the Diagnosis of Tissue Hypoxia (Review)
Общая реаниматология, 2019 The aim of review is to discuss the results of studies on diagnosis of tissue hypoxia by laser-induced spectroscopy, as well as to identify promising trends and prospects of this technique for its further application in experimental and clinical medicine.
Anastasiya S. Babkina
doaj +1 more source
CD36‐mediated lipid rewiring in the metabolic adaptation of tumour ecosystems
The FEBS Journal, EarlyView.Nutrient deprivation drives a lipid‐centric shift in tumour metabolic symbiosis and signalling network. CD36 functions as a bidirectional bridge, transferring fatty acids from stromal donors (adipocytes, CAFs) to the ecosystem tumour‐ and microenvironment‐dependently.
Anna Sebestyén +11 more
wiley +1 more source
Flavin nucleotides in human lens: Regional distribution in Brunescent cataracts
Indian Journal of Ophthalmology, 1998 The biochemical mechanism(s) underlying brunescent cataracts remain unclear. Oxidative stress due to reactive oxygen species may have a role in the pigmentation process in eye lens.
Bhat K, Nayak Sujatha
doaj
New Phytologist, EarlyView.Jasmonate signalling underpins establishment of plant systemic acquired resistance (SAR). Activation of the hypersensitive response (HR) not only contains the pathogen but establishes broad spectrum resistance in unchallenged leaves. The strong burst of reactive oxygen/nitrogen species initiating the HR results in lipid peroxidation (illustrated by ...
Fay Bennett +3 more
wiley +1 more source