Results 61 to 70 of about 82,939 (224)

Advancing Therapies for Mycobacterial Diseases: From Small Molecules to Host‐Directed Strategies

Medicinal Research Reviews, EarlyView.
ABSTRACT The global burden of multidrug‐resistant tuberculosis (MDR‐TB) and the rising incidence of nontuberculous mycobacterial (NTM) infections highlight the urgent need for innovative therapeutic strategies. Current treatments are prolonged, toxic, and increasingly compromised by resistance and limited diagnostic capacity.
Tânia Silva, Alessandra Aiello, Tonino Alonzi, M. Alice Carvalho, Vladimir Finger, Delia Goletti, Sven Hoffner, Yousra Kherabi, Jan Korabecny, Julia Kulczyńska, Agnieszka Kyzioł, Alicia Lacoma, Filomena Martins, Zorica Nanovic, Sepideh Hosseiniporgham, Martina Hrast Rambaher, Leonardo Antonio Sechi, Daria Smalchuk, Grażyna Stochel, Lydia Tabernero, Nancy L. Tateosian, Violeta Valcheva, Anamarija Zega, Mafalda Sarraguça   +23 more
wiley   +1 more source

Label-Free Fluorescence Spectroscopy for Detecting Key Biomolecules in Brain Tissue from a Mouse Model of Alzheimer’s Disease

Scientific Reports, 2017
In this study, label-free fluorescence spectroscopy was used for the first time to determine spectral profiles of tryptophan, reduced nicotinamide adenine dinucleotide (NADH), and flavin denine dinucleotide (FAD) in fresh brain samples of a mouse model ...
Lingyan Shi, Luyao Lu, George Harvey, Thomas Harvey, Adrián Rodríguez-Contreras, Robert R. Alfano   +5 more
doaj   +1 more source

Application of Negative Curvature Hollow-Core Fiber in an Optical Fiber Sensor Setup for Multiphoton Spectroscopy

Sensors, 2017
In this paper, an application of negative curvature hollow core fiber (NCHCF) in an all-fiber, multiphoton fluorescence sensor setup is presented. The dispersion parameter (D) of this fiber does not exceed the value of 5 ps/nm × km across the optical ...
Maciej Andrzej Popenda, Hanna Izabela Stawska, Leszek Mateusz Mazur, Konrad Jakubowski, Alexey Kosolapov, Anton Kolyadin, Elżbieta Bereś-Pawlik   +6 more
doaj   +1 more source

Rotenone Induces Morphological Damage and Reduction in Catecholamine Levels in the Central Nervous System of the Ascidian Styela plicata

Environmental Toxicology, EarlyView.
ABSTRACT Ascidians are invertebrates that occupy a key phylogenetic position as a sister group of the vertebrates. The organization of their central nervous system (CNS), with cortex and medulla, indicates a plesiomorphic character of the gray and white matter of vertebrates, making this group of animals useful for studies of neurodegenerative events ...
Andressa de Abreu Mello, Carlos Augusto Borges de Andrade Gomes, Rafaela Rocha dos Santos, Cintia Monteiro de Barros, Silvana Allodi   +4 more
wiley   +1 more source

Dynamical and structural properties of flavin adenine dinucleotide in aqueous solutions and bound to free and solâgel immobilized glucose oxidase

, 2017
: Optical properties of flavin adenine dinucleotide moiety are nowadays widely used for biotechnological applications. In particular when flavin adenine dinucleotide is bound to glucose oxidase it is employed for developing optical biosensors for glucose
Delfino, Ines, Esposito, Rosario, LEPORE, Maria, PORTACCIO, Marianna Bianca Emanuela   +3 more
core   +1 more source

Structures and mechanism of the monoamine oxidase family

Biomolecular Concepts, 2011
Members of the monoamine oxidase family of flavoproteins catalyze the oxidation of primary and secondary amines, polyamines, amino acids, and methylated lysine side chains in proteins.
Gaweska Helena, Fitzpatrick Paul F.
doaj   +1 more source

Dystrophia Smolandiensis is characterized by a novel NQO1 variant and a distinct phenotype from COL17A1‐associated epithelial recurrent erosion dystrophy

Acta Ophthalmologica, EarlyView.
Abstract Purpose To determine the molecular cause of the two epithelial recurrent erosion dystrophies, Dystrophia Smolandiensis and Dystrophia Helsinglandica, and to identify phenotypic differences between the two conditions. Methods DNA samples and clinical data from structured interview records were obtained from the Swedish families in which ...
Karl De Geer, Kristina Lagerstedt‐Robinson, Daniel Nilsson, Cilla Söderhäll, Björn Hammar, Erik Björck   +5 more
wiley   +1 more source

ENZYMATIC SYNTHESIS AND PHOTOPHYSICAL CHARACTERIZATION OF DUALLY FLUORESCENT FLAVIN ADENINE DINUCLEOTIDE COFACTORS

, 2016
Many enzymes require cofactors in order to carry out specific functions. Flavins, which are naturally fluorescent, compose a unique group of redox cofactors because they have the ability to transfer one or two electrons and are therefore found in three ...
Jacoby, Kimberly Joy
core   +1 more source

Cyclic-FMN Is a Detectable, Putative Intermediate of FAD Metabolism

Biomolecules
Free flavin adenine dinucleotide (FAD) is metabolized to flavin mononucleotide (FMN) and adenine monophosphate (AMP) by hydrolases and to 4′,5′-cyclic phosphoriboflavin (cFMN) and AMP by the triose kinase FMN cyclase (TKFC).
Luxene Belfleur, Juha P. Kallio, Wito Richter, Natalie R. Gassman, Mathias Ziegler, Marie E. Migaud   +5 more
doaj   +1 more source

FLIM as a Promising Tool for Cancer Diagnosis and Treatment Monitoring

Nano-Micro Letters, 2021
Fluorescence lifetime imaging microscopy (FLIM) has been rapidly developed over the past 30 years and widely applied in biomedical engineering. Recent progress in fluorophore-dyed probe design has widened the application prospects of fluorescence ...
Yuzhen Ouyang, Yanping Liu, Zhiming M. Wang, Zongwen Liu, Minghua Wu   +4 more
doaj   +1 more source