Results 31 to 40 of about 111,183 (286)
Crystal structure of the yellow 1:2 molecular complex lumiflavin–bisnaphthalene-2,3-diol [PDF]
, 1971 In the first molecular complex of the physiologically active neutral form of isoalloxazine studied, lumiflavin–bisnaphthalene-2,3-diol, each flavin is sandwiched between two naphthalenediol molecules with extensive overlap but a moderately large (3·44 Å)
Fritchie, Charles J., Jun. +4 more
core +1 more source
Characterization of the Ornithine Hydroxylation Step in Albachelin Biosynthesis
Molecules, 2017 N-Hydroxylating monooxygenases (NMOs) are involved in siderophore biosynthesis. Siderophores are high affinity iron chelators composed of catechol and hydroxamate functional groups that are synthesized and secreted by microorganisms and plants. Recently,
Kendra Bufkin, Pablo Sobrado
doaj +1 more source
QM/MM Modeling of the Flavin Functionalization in the RutA Monooxygenase
Molecules, 2023 Oxygenase activity of the flavin-dependent enzyme RutA is commonly associated with the formation of flavin-oxygen adducts in the enzyme active site. We report the results of quantum mechanics/molecular mechanics (QM/MM) modeling of possible reaction ...
Bella Grigorenko +2 more
doaj +1 more source
Flavin-Dependent Thymidylate Synthase as a New Antibiotic Target
Molecules, 2016 In humans de novo synthesis of 2′-deoxythymidine-5′-monophosphate (dTMP), an essential building block of DNA, utilizes an enzymatic pathway requiring thymidylate synthase (TSase) and dihydrofolate reductase (DHFR). The enzyme flavin-dependent thymidylate
Michael Choi +2 more
doaj +1 more source
mBio, 2023 Many bacteria of the genus Shewanella are facultative anaerobes able to reduce a broad range of soluble and insoluble substrates, including Fe(III) mineral oxides.
Michael P. Norman +8 more
doaj +1 more source
A Riboflavin-Derived Flavinium Salt Mediates Chemoselective Methylation Reactions. [PDF]
ChemistryA two‐component methylation protocol was developed, where the active flavin mediator can be recycled in a single step. Crystallographic data and NMR spectroscopy support the mechanistic proposal, while chemoselective methylation was observed for a broad range of biologically relevant substrates. ABSTRACT Selective methylation is among the most relevant
Langschwager T +3 more
europepmc +2 more sources
Low-carbon energy: a roadmap [PDF]
, 2008 Technologies available today, and those expected to become competitive over the next decade, will permit a rapid decarbonization of the global energy economy.
Christopher Flavin
core
Abelian and non-Abelian statistics in the coherent state representation
, 2011 We further develop an approach to identify the braiding statistics associated to a given fractional quantum Hall state through adiabatic transport of quasiparticles. This approach is based on the notion of adiabatic continuity between quantum Hall states
Flavin, John, Seidel, Alexander
core +2 more sources
Evolutionary and molecular foundations of multiple contemporary functions of the nitroreductase superfamily. [PDF]
, 2017 Insight regarding how diverse enzymatic functions and reactions have evolved from ancestral scaffolds is fundamental to understanding chemical and evolutionary biology, and for the exploitation of enzymes for biotechnology.
Akiva, Eyal +3 more
core +1 more source
FEBS Letters, EarlyView.Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman +2 more
wiley +1 more source