FMN reduces Amyloid-β toxicity in yeast by regulating redox status and cellular metabolism
Nature Communications, 2020 Saccharomyces cerevisiae is a model organism to study proteins involved in neurodegeneration. Here, the authors performed a yeast genome-wide synthetic genetic interaction array (SGA) to screen for toxicity modifiers of Aβ42 and identify riboflavin ...
Xin Chen +6 more
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Mass spectrometry locates local and allosteric conformational changes that occur on cofactor binding
Nature Communications, 2016 The decarboxylate enzyme Fdc1 requires a prenylated flavin mononucleotide co-factor for activity. Here, the authors use a variety of mass spectrometric techniques to observe the structural changes in this protein in response to co-factor binding.
Rebecca Beveridge +5 more
doaj +1 more source
Co-Overexpression of RIB1 and RIB6 Increases Riboflavin Production in the Yeast Candida famata
Fermentation, 2022 Riboflavin or vitamin B2 is a water-soluble vitamin and a precursor of flavin coenzymes, flavin mononucleotide, and flavin adenine dinucleotide, which play a key role as enzyme cofactors in energy metabolism.
Yana Petrovska +4 more
doaj +1 more source
Frontiers in Oncology, 2023 PurposeModern techniques for improved tumor visualization have the aim to maximize the extent of resection during brain tumor surgery and thus improve patient prognosis.
David Reichert +18 more
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Production of Vitamin B2 (Riboflavin) by Microorganisms: An Overview
Frontiers in Bioengineering and Biotechnology, 2020 Riboflavin is a crucial micronutrient that is a precursor to coenzymes flavin mononucleotide and flavin adenine dinucleotide, and it is required for biochemical reactions in all living cells.
Liudmila A. Averianova +8 more
doaj +1 more source
The structural and functional basis of catalysis mediated by NAD(P)H:acceptor Oxidoreductase (FerB) of Paracoccus denitrificans. [PDF]
PLoS ONE, 2014 FerB from Paracoccus denitrificans is a soluble cytoplasmic flavoprotein that accepts redox equivalents from NADH or NADPH and transfers them to various acceptors such as quinones, ferric complexes and chromate.
Vojtěch Sedláček +3 more
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Biophysical characterization of folded state type II luciferase‐like monooxygenase
Indonesian Journal of Biotechnology, 2023 We noticed that the Priestia megaterium genome contains five Luciferase‐like monooxygenase (LLM) encoding genes, however, their functions are unknown. The objective of this work was to characterize the biophysical properties of the recombinant LLM2 from ...
Adinda Fitri Salsabila +4 more
doaj +1 more source
Biomolecules, 2020 Flavin cofactors, like flavin adenine dinucleotide (FAD), are important electron shuttles in living systems. They catalyze a wide range of one- or two-electron redox reactions.
Martina Kieninger +2 more
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Dissolution and mixing of flavin mononucleotide in microfluidic chips for bioassay [PDF]
, 2016 Dissolution and mixing of flavin mononucleotide (FMN), which activates a luminescent reaction, were considered in various designs of microfluidic chip for pollution analysis of liquid samples.
Evstrapov, A. A. +9 more
core +2 more sources
Performance of Protein-Ligand Force Fields for the Flavodoxin-Flavin Mononucleotide System. [PDF]
J Phys Chem Lett, 2016 The ability to accurately perform molecular dynamics and free energy perturbation calculations for protein–ligand systems is of broad interest to the biophysical and pharmaceutical sciences.
Robertson MJ +2 more
europepmc +2 more sources