Results 51 to 60 of about 9,389 (177)

Iron Physiology and Its Impact on Atopic Diseases: An EAACI Taskforce Report

Allergy, EarlyView.
ABSTRACT Iron is essential for oxygen transport, energy metabolism, and immune regulation. Yet iron deficiency is the most common micronutrient disorder across all age groups, affecting nearly one quarter of the global population. Iron deficiency triggers nutritional immunity, a host defense mechanism that withholds and redistributes iron, contributing
Franziska Roth‐Walter, Ioana Agache, Beatriz Cabanillas, Roberto Berni Canani, Pasquale Comberiati, Holger Garn, Cristina Gomez‐Casado, Karin Hufnagl, Ekaterina Khaleva, Gregorio P. Milani, Daniel Munblit, Nikolaos Douladiris, Liam O'Mahony, Frank Redegeld, Carmen Riggioni, Peter K. Smith, Betty van Esch, Emilia Vassilopoulou, Carina Venter, Diego G. Peroni   +19 more
wiley   +1 more source

IR spectroscopic and quantum-chemical manifestation of flavin mononucleotide’s isoalloxazine ring protonation

Біофізичний вісник, 2016
Flavin mononucleotide (FMN) is the prosthetic group of many oxidoreductases performing redox function in cells. The coenzyme reversible reduction reaction involvs isoalloxazine ring which may take two electrons and two protons upon reduction. The spectra
Ю. Н. Близнюк, Д. А. Песина, Д. М. Глибицкий, М. О. Семенов, А. В. Шестопалова   +4 more
doaj  

Unraveling the active site cover of coproheme decarboxylase from Listeria monocytogenes

The FEBS Journal, EarlyView.
During heme biosynthesis in Gram‐positive bacteria, coproheme decarboxylase (ChdC) catalyzes the conversion of four‐propionate substrate coproheme to the two propionate product heme b. Its active site is universally covered by a flexible linking loop. This study identifies an important histidine residue, which stabilizes the loop in a ChdC homolog.
Nikolaus Falb, Dominik Hörtnagel, Chris Oostenbrink, Paul G. Furtmüller, Stefan Hofbauer   +4 more
wiley   +1 more source

Variations in flavin redox states during extracellular electron transfer and electron conduction in Shewanella oneidensis

Electrochemistry Communications
Flavin is one of the most prevalent redox molecules utilized by electroactive bacteria. Electroactive bacteria form a three-dimensional architecture with multiple cell assemblages on electrodes in bioelectrochemical systems.
Yoshihide Tokunou, Hiromasa Tongu, Masanori Toyofuku, Nobuhiko Nomura   +3 more
doaj   +1 more source

A chemo‐enzymatic colorimetric cascade for detecting ethylene glycol contamination

The FEBS Journal, EarlyView.
A chemo‐enzymatic cascade is developed for ethylene glycol (EG) detection. EG is oxidized by GoADH with C1‐mediated cofactor recycling to produce glycolaldehyde (GAL). GAL subsequently reacts with purpald to generate a detectable purple chromophore.
Tawatchai Singphongam, Tadtarit Anujareewat, Wachirawit Chinantuya, Pratchaya Watthaisong, Chayasith Uttamapinant, Somchart Maenpuen, Ruchanok Tinikul   +6 more
wiley   +1 more source

Oxidative and Antioxidant Systems in Ferroptosis of Cancer: Mechanisms, Regulations, and Therapeutic Targeting

MedComm – Oncology, Volume 5, Issue 3, September 2026.
Ferroptosis is governed by the balance between reactive oxygen species (ROS)‐driven lipid peroxidation and a multi‐tiered antioxidant network. ROS sources include mitochondrial electron transport chain, voltage‐dependent anion channels, NADPH oxidases, and endoplasmic reticulum‐resident oxidoreductases, while antioxidant defenses span the primary GSH ...
Deepak K, Pritam Kumar Roy, Maniklal Shee, Budhaditya Mukherjee, Aoife Ward Gahlawat, Mahitosh Mandal   +5 more
wiley   +1 more source

Coupling of Redox and Structural States in Cytochrome P450 Reductase Studied by Molecular Dynamics Simulation

Scientific Reports, 2019
Cytochrome P450 reductase (CPR) is the key protein that regulates the electron transfer from NADPH to various heme-containing monooxygenases. CPR has two flavin-containing domains: one with flavin adenine dinucleotide (FAD), called FAD domain, and the ...
Mikuru Iijima, Jun Ohnuki, Takato Sato, Masakazu Sugishima, Mitsunori Takano   +4 more
doaj   +1 more source

Exploiting the Reverse Function of Ene‐Reductase Enzymes in the Continuous Flow Synthesis of Naphthols From Tetralones

Advanced Synthesis &Catalysis, Volume 368, Issue 16, 18 August 2026.
The development and optimization of a continuous flow method for the use of ERED enzymes in the reverse mode is presented to convert tetralones into naphthols using air as the terminal oxidant. Both solution‐phase and the immobilized enzyme were explored along with different reactor configurations leading to product yields of up to 83% in short ...
Ruairí Bannon, Philip Jamieson, Kathryn Yeow, Megan Smyth, Scott Wharry, Thomas S. Moody, Marcus Baumann   +6 more
wiley   +1 more source

Putative Mechanisms for Initial Reaction of Anaerobic Benzene Degradation Presumably Involving a Flavoprotein

Environmental Microbiology, Volume 28, Issue 8, August 2026.
Anaerobic biodegradation of benzene by sulphate‐reducing strain BzS1 was studied by combining genomics, differential proteomics and targeted metabolite analyses. Strain BzS1 has an exceptionally streamlined metabolism. A highly abundant heterotrimeric flavoprotein may add benzene to either enolpyruvate or glutaconyl‐CoA followed by channelling into the
Florin Musat, Lars Wöhlbrand, Rene Jarling, Michael Kube, Niculina Musat, Patrick Becker, Stefan Bruns, Richard Reinhardt, Rudolf Amann, Friedrich Widdel, Heinz Wilkes, Ralf Rabus   +11 more
wiley   +1 more source

NADPH–Cytochrome P450 Reductase Mediates the Resistance of Aphis (Toxoptera) citricidus (Kirkaldy) to Abamectin

Frontiers in Physiology, 2018
NADPH-cytochrome P450 reductase (CPR) plays an essential role in the cytochrome P450 enzyme system, which aids in the metabolism of endogenous and exogenous compounds including the detoxification of insecticides.
Tian-Xing Jing, Tian-Xing Jing, Yang Tan, Yang Tan, Bi-Yue Ding, Bi-Yue Ding, Wei Dou, Wei Dou, Dan-Dan Wei, Dan-Dan Wei, Jin-Jun Wang, Jin-Jun Wang   +11 more
doaj   +1 more source