Results 71 to 80 of about 28,431 (212)

From identification of fluorescent flavoproteins to mitochondrial redox indicators in intact tissues [PDF]

Journal of Innovative Optical Health Sciences, 2014
Development of the use of flavin and nicotinamide-adenine nucleotide fluorescence in monitoring the redox state of the free mitochondrial NADH/NAD+ couple in cells, tissues and organs is reviewed.
Ilmo E. Hassinen
doaj   +1 more source

DHODH Drives Sunitinib Resistance Via a Non‐Enzymatic Mechanism by Inhibiting TRIM28 Ubiquitination and Consequent VEGFA Activation in RCC

Advanced Science, Volume 13, Issue 52, 18 September 2026.
This non‑enzymatic function of DHODH drives sunitinib resistance by competing with TRIM37 to block TRIM28 ubiquitination, thereby stabilizing TRIM28 and activating VEGFA transcription. Disrupting the DHODH–TRIM28 interaction with lisaftoclax restores drug sensitivity.
Shijie Qian, Shihang Pu, Zhipeng Xu, Yiheng Ding, Ling Jin, Baochao Li, Qi Li, Xiaohai Xi, Zengjun Wang, Jiajun Xing, Aiming Xu   +10 more
wiley   +1 more source

Quantification of riboflavin, flavin mononucleotide, and flavin adenine dinucleotide in mammalian model cells by CE with LED‐induced fluorescence detection

, 2015
Cultured mammalian cells essential are model systems in basic biology research, production platforms of proteins for medical use, and testbeds in synthetic biology.
Neusüß, Christian, Álvaro Ingles‐Prieto, Hühner, Jens, Christian Neusüß, Inglés Prieto, Álvaro ; https://orcid.org/, Harald Janovjak, Lämmerhofer, Michael, Janovjak, Harald L ; https://orcid.org/, Michael Lämmerhofer, Jens Hühner   +9 more
core   +1 more source

Variations in flavin redox states during extracellular electron transfer and electron conduction in Shewanella oneidensis

Electrochemistry Communications
Flavin is one of the most prevalent redox molecules utilized by electroactive bacteria. Electroactive bacteria form a three-dimensional architecture with multiple cell assemblages on electrodes in bioelectrochemical systems.
Yoshihide Tokunou, Hiromasa Tongu, Masanori Toyofuku, Nobuhiko Nomura   +3 more
doaj   +1 more source

Molecular dynamics simulations of riboflavin kinase and flavin mononucleotide riboswitch

<p>Molecular dynamics simulations of the riboflavin kinase and the flavin mononucleotide riboswitch, both in the unbound state and in complex with the riboflavin ligand.
Masetti, Matteo, Rocchia, Walter, Bernetti, Mattia, Bosio, Stefano   +3 more
core   +1 more source

Optimizing Separation Conditions for Riboflavin, Flavin Mononucleotide and Flavin Adenine Dinucleotide in Capillary Zone Electrophoresis with Laser-Induced Fluorescence Detection

, 2002
A method was developed for the quantitative determination of riboflavin, flavin mononucleotide (FMN) and flavin adenine dinucleotide (FAD), using free solution capillary zone electrophoresis in uncoated fused-silica capillaries with laser-induced ...
G. E. DE BENEDETTO, T. R. I. CATALDI, S. A. BUFO, NARDIELLO, DONATELLA   +3 more
core   +2 more sources

Retbindin Dynamically Redistributes to Preserve Retinal Flavin‐Dependent Homeostasis in Response to Riboflavin Availability and Circadian Demand [PDF]

FASEB J
The retina is a part of the central nervous system, has remarkably high energy demands that require efficient retinal metabolism. Dysregulation of retinal metabolism disrupts energy supply and redox balance, leading to the pathogenesis of diverse retinal diseases. Riboflavin and its cofactors, flavin mononucleotide (FMN) and flavin adenine dinucleotide
Zhao X, Makia M, Moiseyev G, Naash M, Al‐Ubaidi M.   +4 more
europepmc   +2 more sources

Coupling of Redox and Structural States in Cytochrome P450 Reductase Studied by Molecular Dynamics Simulation

Scientific Reports, 2019
Cytochrome P450 reductase (CPR) is the key protein that regulates the electron transfer from NADPH to various heme-containing monooxygenases. CPR has two flavin-containing domains: one with flavin adenine dinucleotide (FAD), called FAD domain, and the ...
Mikuru Iijima, Jun Ohnuki, Takato Sato, Masakazu Sugishima, Mitsunori Takano   +4 more
doaj   +1 more source

Sleep Deprivation Induces Glial Dysfunction, Synaptic Loss, Metabolic Imbalance, and Cognitive Impairment in 12‐Month‐Old Mice: Protective Effects of D30

CNS Neuroscience &Therapeutics, Volume 32, Issue 9, September 2026.
Sleep deprivation induces neuroglial atrophy and dendritic spine loss, accompanied by metabolic disturbances involving 1‐methyladenosine, citric acid, L‐kynurenine, and berberine, indicating disrupted neuroenergetic and immunometabolic homeostasis. These alterations result in deficits in spatial recognition, fear conditioning, nesting, and Morris Water
Xueyan Liu, Huiling Lin, Jian Zhong, Xili Chen, Zonglin Wang, Meng Shi, Hang Shi, Hui Zhang, Ping Chen, Zu‐Cheng Ye   +9 more
wiley   +1 more source

Flavin-Dependent Monooxygenases Involved in Biosynthetic Pathways

, 2012
A look at the phylogenetically widespread class of flavin-dependent monooxygenases shows that little is known of those involved in biosynthetic pathways.
Rosanna E. Frederick (17551605)
core   +1 more source