Results 81 to 90 of about 10,776 (205)

Coupling of Redox and Structural States in Cytochrome P450 Reductase Studied by Molecular Dynamics Simulation

Scientific Reports, 2019
Cytochrome P450 reductase (CPR) is the key protein that regulates the electron transfer from NADPH to various heme-containing monooxygenases. CPR has two flavin-containing domains: one with flavin adenine dinucleotide (FAD), called FAD domain, and the ...
Mikuru Iijima, Jun Ohnuki, Takato Sato, Masakazu Sugishima, Mitsunori Takano   +4 more
doaj   +1 more source

Molecular Clocks in Translational Roadmap for Circadian‐Based Therapeutics in Lung Diseases

The FASEB Journal, Volume 40, Issue 10, 31 May 2026.
High‐amplitude circadian oscillations maintain lung immune and epithelial homeostasis. Chronic inflammation dampens peripheral clock amplitude, driving chronodisruption, barrier dysfunction, and remodeling. Clock‐targeted therapies re‐entrain the lung circadian clock, restore rhythmic immune resolution, and promote functional lung repair.
Kingshuk Panda, Renu Khasa, Srinivasan Chinnapaiyan, Saurabh Aggarwal, Irfan Rahman, Hoshang Unwalla   +5 more
wiley   +1 more source

Mapping the evolution of mitochondrial complex I through structural variation

FEBS Letters, Volume 600, Issue 10, Page 1491-1518, May 2026.
Respiratory complex I (CI) is crucial for bioenergetic metabolism in many prokaryotes and eukaryotes. It is composed of a conserved set of core subunits and additional accessory subunits that vary depending on the organism. Here, we categorize CI subunits from available structures to map the evolution of CI across eukaryotes. Respiratory complex I (CI)
Dong‐Woo Shin, Tingting Chen, James A. Letts   +2 more
wiley   +1 more source

Site-Selective Synthesis of ¹⁵N- and ¹³C‑Enriched Flavin Mononucleotide Coenzyme Isotopologues

, 2016
Flavin mononucleotide (FMN) is a coenzyme for numerous proteins involved in key cellular and physiological processes. Isotopically labeled flavin is a powerful tool for studying the structure and mechanism of flavoenzyme-catalyzed reactions by a variety ...
Syam Sundar Neti (2807461), C. Dale Poulter (641717)   +1 more
core   +1 more source

NADPH–Cytochrome P450 Reductase Mediates the Resistance of Aphis (Toxoptera) citricidus (Kirkaldy) to Abamectin

Frontiers in Physiology, 2018
NADPH-cytochrome P450 reductase (CPR) plays an essential role in the cytochrome P450 enzyme system, which aids in the metabolism of endogenous and exogenous compounds including the detoxification of insecticides.
Tian-Xing Jing, Tian-Xing Jing, Yang Tan, Yang Tan, Bi-Yue Ding, Bi-Yue Ding, Wei Dou, Wei Dou, Dan-Dan Wei, Dan-Dan Wei, Jin-Jun Wang, Jin-Jun Wang   +11 more
doaj   +1 more source

Electrospinning of Flavin Mononucleotide-Functionalized Single-Walled Carbon Nanotubes

, 2014
In this contribution, we describe the flavin mononucleotide (FMN) cofactor onto carboxylic functionalities of single-walled carbon nanotubes(SWNTs), using an electrospinning process to create the continuous nanoscale composite fibers from carbon ...
Aphale, Ashish, Patra, Prabir, Wei, Ruoqi   +2 more
core  

A Unique Flavin Mononucleotide-Linked Primary Alcohol Oxidase for Glycopeptide A40926 Maturation

, 2016
The unique pharmacokinetic and pharmacodynamic activities of glycopeptide antibiotics are conferred by tailoring steps occurring on the aglycone. Here, we report that protein Dbv29, involved in the biosynthesis of A40926, is a novel flavin mononucleotide-
Ning-Shian Hsu (1769698), Chia-Chi Huang (2424361), Hsiu-Chien Chan (558360), Tsung-Lin Li (123677), Chun-Yen Lee (335356), Chang-Jer Wu (275760), Yi-Shan Li (816068), Jin-Yuan Ho (214432), Syue-Yi Lyu (1769704), Yu-Ting Huang (112387), Chuan-Jiuan Huang (2469490), Ming-Daw Tsai (123678)   +11 more
core   +1 more source

The RFK catalytic cycle of the pathogen Streptococcus pneumoniae shows species-specific features in prokaryotic FMN synthesis

Journal of Enzyme Inhibition and Medicinal Chemistry, 2018
Emergence of multidrug-resistant bacteria forces us to explore new therapeutic strategies, and proteins involved in key metabolic pathways are promising anti-bacterial targets.
María Sebastián, Adrián Velázquez-Campoy, Milagros Medina   +2 more
doaj   +1 more source

Structural and functional investigation of flavin binding center of the NqrC subunit of sodium-translocating NADH:quinone oxidoreductase from Vibrio harveyi.

PLoS ONE, 2015
Na+-translocating NADH:quinone oxidoreductase (NQR) is a redox-driven sodium pump operating in the respiratory chain of various bacteria, including pathogenic species.
Valentin Borshchevskiy, Ekaterina Round, Yulia Bertsova, Vitaly Polovinkin, Ivan Gushchin, Andrii Ishchenko, Kirill Kovalev, Alexey Mishin, Galina Kachalova, Alexander Popov, Alexander Bogachev, Valentin Gordeliy   +11 more
doaj   +1 more source

Covalent modification of reduced flavin mononucleotide in type-2 isopentenyl diphosphate isomerase by active-site-directed inhibitors

, 2011
Evidence for an unusual catalysis of protonation/deprotonation by a reduced flavin mononucleotide cofactor is presented for type-2 isopentenyl diphosphate isomerase (IDI-2), which catalyzes isomerization of the two fundamental building blocks of ...
Takuya Nagai, Hideaki Unno, Tohru Yoshimura, C. Dale Poulter, Matthew Walter Janczak, Hisashi Hemmi   +5 more
core   +1 more source