Frontiers in Microbiology, 2022 Flavins serve as the electron mediators in Shewanella oneidensis, determining the extracellular electron transfer (EET) rate. Currently, metabolic engineering of flavins biosynthetic pathway has been studied for improving EET.
Lixia Fang +9 more
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Distribution of extracellular flavins in a coastal marine basin and their relationship to redox gradients and microbial community members [PDF]
Environmental Science and Technology, 2018 The flavins (including flavin mononucleotide (FMN) and riboflavin (RF)) are a class of organic compounds synthesized by organisms to assist in critical redox reactions.
Baronas, J. Jotautas +7 more
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Flavins Act as a Critical Liaison Between Metabolic Homeostasis and Oxidative Stress in the Retina
Frontiers in Cell and Developmental Biology, 2020 Derivatives of the vitamin riboflavin, FAD and FMN, are essential cofactors in a multitude of bio-energetic reactions, indispensable for lipid metabolism and also are requisites in mitigating oxidative stress.
Tirthankar Sinha +2 more
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Expanding the chemical space of flavins with pentacyclic architecture [PDF]
Nature CommunicationsInspired by the prominent redox and optical properties of natural flavins, synthetic flavins have found broad applications in organic, photochemical, and biochemical research. Tailoring these properties of flavins, however, remains a challenge.
Dayeong Seo +7 more
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Impact of low-intensity 463 nm blue light on proliferation and adaptive mutation of Escherichia coli DH5α cells [PDF]
Scientific ReportsThe growth rate of many microorganisms decreases when exposed to blue light (BL) at around 450 nm. This growth retardation is likely caused by the photosensitivity of endogenous photosensitizers, flavins, which absorb BL and generate reactive oxygen ...
Nagomi Matsumoto, Osamu Hisatomi
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N5 Is the New C4a: Biochemical Functionalization of Reduced Flavins at the N5 Position
Frontiers in Molecular Biosciences, 2020 For three decades the C4a-position of reduced flavins was the known site for covalency within flavoenzymes. The reactivity of this position of the reduced isoalloxazine ring with the dioxygen ground-state triplet established the C4a as a site capable of ...
Brett A. Beaupre, Graham R. Moran
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Photo-excited extracellular electron transfer of electroactive microorganism triggers RAFT polymerization [PDF]
Nature CommunicationsLiving cell-triggered reversible addition-fragmentation chain-transfer (RAFT) polymerization is of great value for construction of living materials with diverse applications.
Chao Li +13 more
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Neuroprotective effect of riboflavin kinase on cerebral ischemia injury in rats [PDF]
Molecular MedicineBackground Riboflavin kinase (RFK, also called flavokinase) is a catalytic enzyme that converts riboflavin to its active form in vivo. Dysfunction of the RFK gene has been associated with susceptibility to ischemic stroke.
Yingxin Zou +6 more
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Flavins and Flavoproteins in the Neuroimmune Landscape of Stress Sensitization and Major Depressive Disorder [PDF]
Journal of Inflammation ResearchMatt Scott Schrier,1 Maria Igorevna Smirnova,2– 4 Daniel Paul Nemeth,1 Richard Carlton Deth,5 Ning Quan1,3 1Department of Biomedical Science, Charles E.
Schrier MS +4 more
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Multispectral Imaging of Collagen, NAD(P)H and Flavin Autofluorescence in Mesenchymal Stem Cells Undergoing Trilineage Differentiation [PDF]
CellsUnderstanding the molecular mechanisms of differentiation is important for regenerative medicine and developmental biology. This study aims to characterise the role of the glycolysis/oxidative phosphorylation balance as a driver of mesenchymal stem cell (
Jared M. Campbell +9 more
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