Expanding the chemical space of flavins with pentacyclic architecture [PDF]
Nature CommunicationsInspired by the prominent redox and optical properties of natural flavins, synthetic flavins have found broad applications in organic, photochemical, and biochemical research. Tailoring these properties of flavins, however, remains a challenge.
Dayeong Seo +7 more
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Flavins and Flavoproteins in the Neuroimmune Landscape of Stress Sensitization and Major Depressive Disorder [PDF]
Journal of Inflammation ResearchMatt Scott Schrier,1 Maria Igorevna Smirnova,2– 4 Daniel Paul Nemeth,1 Richard Carlton Deth,5 Ning Quan1,3 1Department of Biomedical Science, Charles E.
Schrier MS +4 more
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Systematic Theoretical Study on the pH-Dependent Absorption and Fluorescence Spectra of Flavins [PDF]
Molecules, 2023 Flavins are a class of organic compounds with the basic structure of 7,8-dimethy-10-alkyl isoalloxazine. They are ubiquitous in nature and participate in many biochemical reactions. Due to various existing forms, there is a lack of systematic research on
Jinyu Wang, Yajun Liu
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Impact of low-intensity 463 nm blue light on proliferation and adaptive mutation of Escherichia coli DH5α cells [PDF]
Scientific ReportsThe growth rate of many microorganisms decreases when exposed to blue light (BL) at around 450 nm. This growth retardation is likely caused by the photosensitivity of endogenous photosensitizers, flavins, which absorb BL and generate reactive oxygen ...
Nagomi Matsumoto, Osamu Hisatomi
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Photo-excited extracellular electron transfer of electroactive microorganism triggers RAFT polymerization [PDF]
Nature CommunicationsLiving cell-triggered reversible addition-fragmentation chain-transfer (RAFT) polymerization is of great value for construction of living materials with diverse applications.
Chao Li +13 more
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Neuroprotective effect of riboflavin kinase on cerebral ischemia injury in rats [PDF]
Molecular MedicineBackground Riboflavin kinase (RFK, also called flavokinase) is a catalytic enzyme that converts riboflavin to its active form in vivo. Dysfunction of the RFK gene has been associated with susceptibility to ischemic stroke.
Yingxin Zou +6 more
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Reprogramming Listeria monocytogenes flavin metabolism to improve its therapeutic safety profile and broaden innate T-cell activation [PDF]
mBioListeria monocytogenes is a facultative intracellular bacterial pathogen that is a potent inducer of cell-mediated immunity, which has led to the development of attenuated, Listeria-based cancer vaccines. L. monocytogenes strains, such as live-attenuated
Victoria Chevée +13 more
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Multispectral Imaging of Collagen, NAD(P)H and Flavin Autofluorescence in Mesenchymal Stem Cells Undergoing Trilineage Differentiation [PDF]
CellsUnderstanding the molecular mechanisms of differentiation is important for regenerative medicine and developmental biology. This study aims to characterise the role of the glycolysis/oxidative phosphorylation balance as a driver of mesenchymal stem cell (
Jared M. Campbell +9 more
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Reduced Molecular Flavins as Single-Electron Reductants after Photo-Excitation [PDF]
, 2021 Flavoenzymes mediate a multitude of chemical reactions and are catalytically active both in different oxidation states and in covalent adducts with reagents.
Jürgen, Hauer +5 more
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Journal of the American Chemical Society, 2023 Most flavin-dependent enzymes contain a dissociable flavin cofactor. We present a new approach for installing a covalent bond between a flavin cofactor and its hosting protein. By using a flavin transferase and carving a flavinylation motif in target proteins, we demonstrate that ‘dissociable’ flavoproteins can be turned into covalent flavoproteins ...
Yapei Tong +5 more
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