Mapping glycoprotein structure reveals Flaviviridae evolutionary history
NatureViral glycoproteins drive membrane fusion in enveloped viruses and determine host range, tissue tropism and pathogenesis1. Despite their importance, there is a fragmentary understanding of glycoproteins within the Flaviviridae2, a large virus family that
Jonathon C O Mifsud +2 more
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Proposed revision to the taxonomy of the genus Pestivirus, family Flaviviridae [PDF]
Journal of General Virology, 2017 We propose the creation of seven new species in the genus Pestivirus (family Flaviviridae) in addition to the four existing species, and naming species in a host-independent manner using the format Pestivirus X. Only the virus species names would change;
Donald B. Smith +10 more
semanticscholar +7 more sources
In Vivo Dynamics of Reporter Flaviviridae Viruses [PDF]
Journal of Virology, 2019 In vivo applications of reporter viruses are necessary to understand viral pathogenesis and provide a robust platform for antiviral development. In developing such applications, determination of an ideal locus to accommodate foreign genes is important ...
Tomokazu Tamura +13 more
semanticscholar +4 more sources
Zika Virus Genomic RNA Possesses Conserved G-Quadruplexes Characteristic of the Flaviviridae Family
ACS Infectious Diseases, 2016 Zika virus has emerged as a global concern because neither a vaccine nor antiviral compounds targeting it exist. A structure for the positive-sense RNA genome has not been established, leading us to look for potential G-quadruplex sequences (PQS) in the ...
Aaron M Fleming, Yun Ding, Anton Alenko
exaly +2 more sources
Conserved RNA secondary structures in Flaviviridae genomes [PDF]
Journal of General Virology, 2004 Presented here is a comprehensive computational survey of evolutionarily conserved secondary structure motifs in the genomic RNAs of the family Flaviviridae. This virus family consists of the three genera Flavivirus, Pestivirus and Hepacivirus and the group of GB virus C/hepatitis G virus with a currently uncertain taxonomic classification.
Caroline Thurner +3 more
openalex +3 more sources
Beyond Members of the Flaviviridae Family, Sofosbuvir Also Inhibits Chikungunya Virus Replication [PDF]
Antimicrobial Agents and Chemotherapy, 2018 Chikungunya virus (CHIKV) causes a febrile disease associated with chronic arthralgia, which may progress to neurological impairment. Chikungunya fever (CF) is an ongoing public health problem in tropical and subtropical regions of the world, where ...
André C. Ferreira +21 more
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Virus-Like Particle Systems for Vaccine Development against Viruses in the Flaviviridae Family
Vaccines, 2019 Viruses in the Flaviviridae family are important human and animal pathogens that impose serious threats to global public health. This family of viruses includes emerging and re-emerging viruses, most of which are transmitted by infected mosquito or tick ...
Shu Hui Wong +5 more
doaj +2 more sources
Virus-encoded proteinases of the Flaviviridae.
Journal of General Virology, 1998 Martin D. Ryan +2 more
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Architects of assembly: roles of Flaviviridae non-structural proteins in virion morphogenesis [PDF]
Nature Reviews Microbiology, 2008 Catherine Murray +2 more
exaly +2 more sources
NTPase/helicase of Flaviviridae: inhibitors and inhibition of the enzyme.
Acta Biochimica Polonica, 2002 RNA nucleoside triphosphatases (NTPase)/helicases represent a large family of proteins that are ubiquitously distributed over a wide range of organisms. The enzymes play essential role in cell development and differentiation, and some of them are involved in transcription and replication of viral single-stranded RNA genomes. The enzymatic activities of
Peter Borowski +6 more
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