Results 41 to 50 of about 123,964 (265)

Melanoxetin: A Hydroxylated Flavonoid Attenuates Oxidative Stress and Modulates Insulin Resistance and Glycation Pathways in an Animal Model of Type 2 Diabetes Mellitus

Pharmaceutics
Type 2 diabetes mellitus (DM) continues to escalate, necessitating innovative therapeutic approaches that target distinct pathways and address DM complications.
Sónia Rocha, Andreia Amaro, Marcos D. Ferreira-Junior, Carina Proença, Artur M. S. Silva, Vera M. Costa, Sara Oliveira, Diogo A. Fonseca, Sónia Silva, Maria Luísa Corvo, Marisa Freitas, Paulo Matafome, Eduarda Fernandes   +12 more
doaj   +1 more source

LC-ESI-QTOF/MS Characterization of Phenolic Compounds in Palm Fruits (Jelly and Fishtail Palm) and Their Potential Antioxidant Activities

Antioxidants, 2019
Palm fruits have gained growing attention for their nutrition values and health promotion perspectives. They have a diverse range of bioactive compounds including carotenoids, vitamins, dietary fibres and especially polyphenolic compounds.
Chao Ma, Frank R. Dunshea, Hafiz A. R. Suleria   +2 more
doaj   +1 more source

Resistant Peanut Genotype Reprograms Rhizosphere Metabolism to Enhance Bacterial Wilt Suppression

Advanced Science, EarlyView.
The resistant peanut genotype selectively recruits beneficial bacteria, which coincides with the activation of salicylic acid (SA)‐dependent systemic acquired resistance (SAR) against Ralstonia solanacearum. Keystone rhizosphere metabolites are positively correlated with both beneficial microbiome assembly and SAR gene expression.
Rui Ren, Xiaogang Li, Hao Li, Zenghui Cao, Mengtian Hou, Chunlei Zhao, Nan Lou, Sasa Hu, Yanzhe Li, Qian Ma, Yaoyao Li, Yi Fan, Kunkun Zhao, Kai Zhao, Ding Qiu, Fangping Gong, Zhongfeng Li, Haitao Liu, Xingli Ma, Xingxiang Wang, Dongmei Yin   +20 more
wiley   +1 more source

Intrinsically Mitochondria‐Targeting Nanozyme via Coordination‐Assembly of Natural Quercetin for Cascade Antioxidant Therapy of Cerebral Ischemia‐Reperfusion Injury

Advanced Science, EarlyView.
This study uncovers that quercetin naturally targets mitochondria. By coordinating quercetin with Fe3+, we engineer an ultrasmall cascade nanozyme (MCN) with superoxide dismutase‐catalase activities. MCN crosses the damaged blood–brain barrier, scavenges mitochondrial ROS, prevents mitochondrial DNA leakage, and blocks the cGAS‐STING pathway, thereby ...
Wenxuan Zheng, Zhicheng Wang, Xin Zhou, Shuya Wang, Xiaojing Shi, Tingli Xiong, Ruishi Li, Yuting Lin, Zhen Chen, Jiawen Wei, Fei Li, Jinwen Ge, Kelong Ai, Chong Liu, Guiming Deng   +14 more
wiley   +1 more source

Virtual Screening of Syzygium cumini (L.) Skeels Flavonoid Compounds as SARS-CoV-2 Main Protease Therapy Candidates

Jurnal Kimia Sains dan Aplikasi
In December 2019, the first COVID-19 cases were in Wuhan, China. This case is a global concern and a threat to public health. Based on previous research using molecular docking methods, it was found that flavonoids exhibit strong inhibitory activity in ...
Himyatul Hidayah, Ruswanto Ruswanto, Desri Lestari, Surya Amal, Neni Sri Gunarti   +4 more
doaj   +1 more source

A Blood‐Derived Double‐Network Hydrogel with Robust Wet Adhesion for Keratinized Mucosa Regeneration via Neutrophil Phenotype Reprogramming and Mechanophysical Niche Modulation

Advanced Science, EarlyView.
The iPRF‐MA/Alg‐NHS/Lut@EGCG (PGAE) double‐network hydrogel achieves durable wet adhesion in the oral environment. It simultaneously reprograms neutrophils from NETosis to phagocytosis for biofilm clearance, and activates the FAK‐RhoA‐YAP mechanotransduction pathway in gingival fibroblasts to drive extracellular matrix remodeling, thereby promoting ...
Sicong Ren, Xinting Yang, Jingxia Chen, Yihan Wang, Jian Feng, Jing Zhou, Jiaxin Luo, Jingjie Zhai, Quan Lin, Yanmin Zhou   +9 more
wiley   +1 more source

The key metabolic genes and networks regulating the fruit acidity and flavonoid of Prunus mume revealed via transcriptomic and metabolomic analyses

Frontiers in Plant Science
The acidic taste of Mei fruit (Prunus mume) is a major contributor to its quality, but its formation mechanism remains unclear. Here, we unraveled the networks of organic acid and flavonoid metabolism in two Mei fruit.
Xuan Gao, Shuangshuang Wu, Guosheng Lv, Mengyang Wang, Lingxiang Li, Yahui Liu, Feng He, Jiaxin Xiao   +7 more
doaj   +1 more source

Natural Variation of COLD and CATECHINS REGULATOR 1 Coordinately Fine‐Tunes Cold Tolerance and Tea Quality in Tea Plants

Advanced Science, EarlyView.
Multi‐trait genome‐wide association mapping identifies a central hub regulator, COLD AND CATECHINS REGULATOR 1 (CCR1), and its excellent natural allele variation, coordinately enhancing cold tolerance and promoting catechins biosyntheis. CsCCR1 interacts with CsCBF1/3 and is transcriptionally activated by CsLUX and CsKUA1 to promote catechins ...
Yanli Wang, Wei Tong, Qiong Wu, Didi Wu, Yanrui Zhang, Qijuan Gao, Fangdong Li, Zhaoliang Zhang, Wenjie Wang, Chuankui Song, Enhua Xia   +10 more
wiley   +1 more source

Metagenomic Association Uncovers Host Genotype‐Structured Rhizobacterial Networks and Novel Taxa That Enhance Soybean Salt Tolerance

Advanced Science, EarlyView.
An STI‐guided metagenomic association framework links soybean salt‐tolerance phenotypes with rhizosphere microbiome composition and network organization in natural saline soils. The approach identifies candidate beneficial taxa, including Thalassospira xiamenensis, and provides an efficient strategy for mining stress‐protective microbes from native ...
Yu Luo, Feng‐Li Kang, Qi‐Min Li, Wei‐Cai Yang   +3 more
wiley   +1 more source

Genome-Wide Identification and Analysis of GATA Gene Family in Dendrobium officinale Under Methyl Jasmonate and Salt Stress

Plants
Dendrobium officinale, which was rich in bioactive compounds such as polysaccharides, alkaloids, amino acids, and flavonoids, had significant medicinal value and ability to resist stresses. Studies had demonstrated that GATA genes were one of the crucial
Zhangting Xu, Feixiong Zheng, Xiaoji Deng, Yiming Sun, Zhenming Yu, Xiaoxia Shen   +5 more
doaj   +1 more source