Results 131 to 140 of about 29,275 (243)

Feasibility of In Vivo Retinal Flavoprotein Autofluorescence Imaging in a Magnetic‐Bead‐Induced Rodent Glaucoma Model

Journal of Biophotonics, Volume 19, Issue 6, June 2026.
A scanning laser ophthalmoscope, integrated with a real‐time optical coherence tomography (OCT) alignment monitor, detected flavoprotein fluorescence (FPF) signals associated with mitochondrial dysfunction in a rodent glaucoma model. Under 450‐nm excitation, experimental eyes showed spatially inhomogeneous signals that were absent under 505‐nm ...
Eun Ji Lee, Jiwon Kang, Jung‐Ho Chung, Kyoung Min Lee, Yu Jin Roh, Dong Kyun Han   +5 more
wiley   +1 more source

Extracellular Vesicles of Giardia duodenalis: Unravelling Their Virulence Factors and Potential to Induce Protection Against Experimental Giardiasis

Journal of Extracellular Biology, Volume 5, Issue 6, June 2026.
ABSTRACT Extracellular vesicles (EVs) are key mediators of intercellular communication, enabling trans‐kingdom exchange of proteins, nucleic acids, lipids, and metabolites. In Giardia duodenalis, EVs contribute to parasite survival, host–pathogen interactions, and immune modulation.
Corral‐Ruiz Gerardo, Argüello‐García Raúl, Ortiz‐Lozano Dalia, Salazar‐Villatoro Lizbeth, Pech‐Santiago Edar Onam, Espinosa‐Cantellano Martha, Hernández‐Cueto Daniel, Silva‐Olivares D. Angélica, Betanzos Abigail, Ortega‐Pierres M. Guadalupe   +9 more
wiley   +1 more source

NADPH Dehydrogenase Gene Regulates Energy Distribution and Fatty Acid Metabolism During Fruiting Body Formation in the Filamentous Fungus Podospora anserina

Microbial Biotechnology, Volume 19, Issue 6, June 2026.
NADPH dehydrogenase gene deletion significantly triggered NADPH/NADP+ increase in mutant strains. NADPH gene deletion promoted Fatty acid biosynthesis and repressed β‐oxidation. NADPH gene deletion decreased oxidative phosphorylation and increased substrate‐level phosphorylation. Mutants exhibited hypersensitivity to oxidative stress, but promoted more
Yanling Qiu, Amechi S. Nwankwegu, Yue Sun, Yuanjing Li, Weizhao Chen, Gang Liu, Ning Xie   +6 more
wiley   +1 more source

Endogenous Flavoprotein Fluorescence Imaging Revealed Increased Metabolic Stress in Nonarteritic Anterior Ischemic Optic Neuropathy

, 2023
Endogenous flavoprotein fluorescence (FPF) imaging is an emerging functional assessment of optic neuropathies and retinopathies. An increase in FPF indicates oxidative stress in vivo due to increased blue light absorption and green light emission that ...
Sangeethabalasri Pugazhendhi; Miaomiao Yu; Ping Zhu; Collin Rich; Yaping Joyce Liao
core  

Flavoprotein semiquinone [PDF]

Biochemical Journal, 1972
openaire   +2 more sources

Altitude‐Associated Divergence of the Gut Microbiome in Endangered Forest Musk Deer: Evidence From Integrated Metagenomics, Metabolomics, and Culturomics

Evolutionary Applications, Volume 19, Issue 6, June 2026.
ABSTRACT High‐altitude environments expose mammals and their gut symbionts to multifaceted stressors—hypoxia, cold, and intense UV radiation. Whether gut microbial communities undergo compositional restructuring in response to these stressors, and whether such restructuring carries translational value for captive conservation, remain unresolved ...
Feiyun Huang, Zexiu Zhang, Yanni Zhao, Sen Ye, Maoyuan Gan, Xuxin Li, Yele Zhang, Lei Chen, Yushuo Zhang, Lingxi Chen, Ting Wang, Jinming Huang, Xiuyue Zhang   +12 more
wiley   +1 more source

Energetic stress in combination with impaired fatty acid oxidation induces sequestration of CoA and adaptation of CoA metabolism

The FEBS Journal, Volume 293, Issue 12, Page 3565-3587, June 2026.
Computational modelling and in vitro liver cell experiments indicate that medium‐chain acyl‐CoA dehydrogenase (MCAD) deficiency causes an accumulation of (especially medium‐chain) acyl‐CoAs at the cost of free CoA (CoASH). A substantial decrease in CoASH impairs flux through many pathways essential for energy homeostasis.
Ligia Akemi Kiyuna, Christoff Odendaal, Madhulika Singh, Albert Gerding, Miriam Langelaar‐Makkinje, Marianne van der Zwaag, Asmara Drachman, Vladimíra Cetkovská, Gaby Liem Foeng Kioen, Anne‐Claire M. F. Martines, Nicolette C. A. Huijkman, Hein Schepers, Bart van de Sluis, Dirk‐Jan Reijngoud, Ody C. M. Sibon, Amy C. Harms, Thomas Hankemeier, Barbara M. Bakker   +17 more
wiley   +1 more source

Principles of intrinisic flavoprotein and NAD(P)H fluorescent imaging.

, 2016
Instrinsic flavoprotein (FA) and NAD(P)H fluorescent signals are attributed to mitochondrial activity. Changes in fluorescence are correlated with neuronal activity through increases in metabolic demand resulting from ionic pumps and synaptic activity ...
Cedric R. Uytingco (3371243), Adam C. Puche (266747), Steven D. Munger (266748)   +2 more
core   +1 more source

Unveiling protective mechanisms of wild olive (acebuche) oil in retinal pigment epithelial cells with hypertensive phenotype

The Journal of Physiology, Volume 604, Issue 11, Page 4166-4185, 1 June 2026.
Abstract figure legend Circulating extracellular vesicles (EVs) derived from acebuche (ACE) oil‐ and extra virgin olive oil (EVOO)‐fed mice modulate nitric oxide (NO) metabolism in the retinal pigment epithelial cell line (ARPE19) with a hypertensive phenotype induced by angiotensin II (AngII).
Álvaro Santana‐Garrido, Claudia Reyes‐Goya, Pablo Espinosa‐Martín, Rosa M. Troya‐Toledo, Helder André, Alfonso Mate, Carmen M. Vázquez   +6 more
wiley   +1 more source

Flavoproteins in Directed Evolution

, 2010
In der vorliegenden Arbeit wurden zwei Enzyme, eine Enoatreduktase (YqjM) und eine Monooxigenase (\(P450_{BM3}\)), mittels "Gerichteter Evolution" auf die Akzeptanz neuer Substrate angepasst. Mittel iterativem CASTing (combinatorial active site saturation test) konnten in beiden Fällen hoch regio- und stereoselektive Mutanten erhalten werden ...
openaire   +2 more sources