Results 21 to 30 of about 82,470 (284)

Neuroinflammation and structural injury of the fetal ovine brain following intra-amniotic Candida albicans exposure. [PDF]

, 2016
BackgroundIntra-amniotic Candida albicans (C. Albicans) infection is associated with preterm birth and high morbidity and mortality rates. Survivors are prone to adverse neurodevelopmental outcomes.
AJ Wolfberg, Allan H. Jobe, AM Alsaad, AW Gavilanes, AW Gavilanes, B Fleiss, BE Deverman, Benno Küsters, BH Yoon, Boris W. Kramer, C Perego, C Perego, Daan R. M. G. Ophelders, DB DiGiulio, DH Navarathna, E Kuypers, E Kuypers, E Rocha, G Maneenil, HJ Bonestroo, IC Hoogland, JJ Collins, JJ Volpe, JM Dean, John P. Newnham, JR Buser, KN Segovia, LC Schmued, LM Bean, Luc J. Zimmermann, M Atzori, M Gantert, Martin Lammens, Matthew S. Payne, Matthew W. Kemp, MJ Keogh, MS Lionakis, MS Payne, MS Payne, MW Kemp, NY Tsai, O Dammann, O Dammann, R Filipovic, R Galinsky, R Gomez, RL Goldenberg, RL Goldenberg, Ruth Gussenhoven, S Biesmans, S Malaeb, S Rees, S Rivest, SA Back, SA Back, SS Billiards, Suhas G. Kallapur, T Meizoso, TG Wolfs, Tim G. A. M. Wolfs, V Agrawal, V Chau, VV Moudgal, YW Wu   +63 more
core   +4 more sources

Limited Activity Of Miltefosine In Murine Models Of Cryptococcal Meningoencephalitis And Disseminated Cryptococcosis [PDF]

, 2013
Miltefosine is an alkyl phosphocholine with good oral bioavailability and in vitro activity against Cryptococcus species that has gained interest as an additional agent for cryptococcal infections.
Bocanegra, Rosie, Kirkpatrick, William R., Najvar, Laura K., Patterson, Thomas F., Sorrell, Tania C., Wiederhold, Nathan P.   +5 more
core   +1 more source

Reduced susceptibility to fluconazole in a cat with histoplasmosis

Journal of Feline Medicine and Surgery Open Reports, 2017
Case summary An 11-year-old neutered male domestic longhair cat was diagnosed with histoplasmosis from fine-needle aspirates of an abdominal lymph node. Lymph node size initially decreased with fluconazole therapy (11.8 mg/kg PO q12h); however, after 13 ...
Janelle S Renschler, Gary D Norsworthy, Rubie A Rakian, Audrey I Rakian, Lawrence J Wheat, Andrew S Hanzlicek   +5 more
doaj   +1 more source

Metabolome and Transcriptome Combinatory Profiling Reveals Fluconazole Resistance Mechanisms of Trichosporon asahii and the Role of Farnesol in Fluconazole Tolerance

Microorganisms, 2023
Trichosporon asahii is a basidiomycete yeast that is pathogenic to humans and animals, and fluconazole-resistant strains have recently increased. Farnesol secreted by fungi is a factor that causes variations in fluconazole resistance; however, few ...
Xiaoping Ma, Wanling Yang, Aining Yang, Dong Chen, Chengdong Wang, Shanshan Ling, Sanjie Cao, Zhicai Zuo, Ya Wang, Zhijun Zhong, Guangneng Peng, Ming He, Yu Gu   +12 more
doaj   +1 more source

The transcription factor Rpn4 activates its own transcription and induces efflux pump expression to confer fluconazole resistance in Candida auris

mBio, 2023
The emergence and nosocomial spread of the multidrug-resistant Candida auris pose a severe public health threat. Most C. auris clinical isolates are fluconazole resistant.
Eve W. L. Chow, Yabing Song, Jinxin Chen, Xiaoli Xu, Jianbin Wang, Kun Chen, Jiaxin Gao, Yue Wang   +7 more
doaj   +1 more source

First Report of Ventriculoperitoneal Shunt Infection due to Cyberlindnera fabianii. [PDF]

, 2015
Fungal infections in the central nervous system (CNS) are associated with significant morbidity and death. Transient fungemia in immunocompetent patients without any other risk factors for fungemia has been suggested as a possible mechanism that may lead
Baghdadi, Jonathan, Hemarajata, Peera, Humphries, Romney, Kelesidis, Theodoros   +3 more
core   +3 more sources

Adhesive Properties and Sensitivity to Antifungal Drugs of Candida Albicans, Which Are Released From Patients of Gastroenterological Profile with Candidiasis of the Mucosa of the Upper Part of the Digestive Tract [PDF]

, 2016
Candida albicans were released from 146 loci from 89 patients in order to perform the investigation. The fourth stage of contamination by Candida albicans in the scrape from the tongue and candidiasis of the esophagus or /and the stomach during ...
Kushnirenko, I. (Inessa)
core   +2 more sources

Sphingolipid Inhibitors as an Alternative to Treat Candidiasis Caused by Fluconazole-Resistant Strains

Pathogens, 2021
Candida species are fungal pathogens known to cause a wide spectrum of diseases, and Candida albicans and Candida glabrata are the most common associated with invasive infections.
Rodrigo Rollin-Pinheiro, Brayan Bayona-Pacheco, Levy Tenorio Sousa Domingos, Jose Alexandre da Rocha Curvelo, Gabriellen Menezes Migliani de Castro, Eliana Barreto-Bergter, Antonio Ferreira-Pereira   +6 more
doaj   +1 more source

Fluconazole Penetration into the Pancreas [PDF]

Antimicrobial Agents and Chemotherapy, 2000
ABSTRACT Because of antibiotic prophylaxis for necrotizing pancreatitis, the frequency of fungal superinfection in patients with pancreatic necrosis is increasing. In this study we analyzed the penetration of fluconazole into the human pancreas and in experimental acute pancreatitis.
Claudia Issenegger, Beat Gloor, Helmut Friess, R A Yeates, Jörg Kleeff, Huang Yong, Shailesh V. Shrikhande, Markus W. Büchler, Marcus E. Martignoni   +8 more
openaire   +3 more sources

A natural histone H2A variant lacking the Bub1 phosphorylation site and regulated depletion of centromeric histone CENP-A foster evolvability in Candida albicans. [PDF]

, 2019
Eukaryotes have evolved elaborate mechanisms to ensure that chromosomes segregate with high fidelity during mitosis and meiosis, and yet specific aneuploidies can be adaptive during environmental stress.
Brimacombe, Cedric A, Burke, Jordan E, Burrack, Laura S, Catania, Sandra, Madhani, Hiten D, Noble, Suzanne M, O'Meara, Teresa R, Parsa, Jahan-Yar, Witchley, Jessica N   +8 more
core   +3 more sources