Results 61 to 70 of about 86,931 (273)

SWL-1 Reverses Fluconazole Resistance in Candida albicans by Regulating the Glycolytic Pathway

Frontiers in Microbiology, 2020
Candida albicans is a ubiquitous clinical fungal pathogen. Prolonged use of the first-line antifungal agent fluconazole (FLC) has intensified fungal resistance and limited its effectiveness for the treatment of fungal infections.
Xiao-Ning Li, Xiao-Ning Li, Lu-Mei Zhang, Lu-Mei Zhang, Yuan-Yuan Wang, Yi Zhang, Yi Zhang, Ze-Hua Jin, Ze-Hua Jin, Jun Li, Jun Li, Rui-Rui Wang, Rui-Rui Wang, Wei-Lie Xiao   +13 more
doaj   +1 more source

Fluconazole-resistant Candida parapsilosis: A new emerging threat in the fungi arena

Frontiers in Fungal Biology, 2022
Candida parapsilosis is a leading cause of invasive candidiasis in southern Europe, Latin America and Asia. C. parapsilosis has been mostly considered susceptible to triazoles, but fluconazole resistance is on the rise in some countries.
Pilar Escribano, Pilar Escribano, Jesús Guinea, Jesús Guinea, Jesús Guinea   +4 more
doaj   +1 more source

Emerging fluconazole resistance: Implications for the management of cryptococcal meningitis

Medical Mycology Case Reports, 2018
We present the case of an HIV-seropositive individual with cryptococcal meningitis who was found to have a fluconazole resistant strain of Cryptococcus neoformans.
Edward Mpoza, Joshua Rhein, Mahsa Abassi
doaj   +1 more source

Improvement of experimental testing and network training conditions with genome-wide microarrays for more accurate predictions of drug gene targets [PDF]

, 2014
BACKGROUND: Genome-wide microarrays have been useful for predicting chemical-genetic interactions at the gene level. However, interpreting genome-wide microarray results can be overwhelming due to the vast output of gene expression data combined with off-
Christadore, Lisa M., Kolaczyk, Eric D., Pham, Lisa, Schaus, Scott E.   +3 more
core   +1 more source

Azole antifungal contaminants disrupt mycorrhizal function and risk agricultural sustainability

PLANTS, PEOPLE, PLANET, EarlyView.
Global food production is increasingly threatened by soil degradation, climate change and the rising costs of synthetic fertilisers. Circular agriculture, which promotes resource reuse, is a promising solution, but using treated wastewater and biosolids in farming introduces risks from emerging contaminants like pharmaceutical residues.
Emily K. Durant, Katie J. Field, J. Brett Sallach, Sara Moeskjær, Alex Williams, Laura J. Carter   +5 more
wiley   +1 more source

Candida albicans  Genotyping and Relationship of Virulence Factors with Fluconazole Tolerance in Infected Pediatric Patients

Infection and Drug Resistance, 2022
Ghada El-Saeed Mashaly,1 Mayada Sabry Zeid2 1Medical Microbiology and Immunology Department, Faculty of Medicine, Mansoura University, Mansoura, Egypt; 2Infectious Diseases and Malnutrition, Pediatrics Department, Faculty of Medicine, Mansoura University,
Mashaly GE, Zeid MS
doaj  

Fungicidal activity plus reservoir effect allow short treatment courses with terbinafine in tinea pedis [PDF]

, 2008
Terbinafine, a synthetic allylamine, exerts fungicidal activity against dermatophytes, the causative pathogens of tinea pedis. As proven in numerous clinical trials, tinea pedis can be effectively and safely treated by topical terbinafine.
Korting, Hans Christian, Schäfer-Korting, Monika, Schöllmann, C.   +2 more
core   +1 more source

An integrated social and natural sciences case study for the reuse of organic wastes as soil amendments

PLANTS, PEOPLE, PLANET, EarlyView.
Reusing organic waste materials, such as animal manure, as soil amendments reduces water and fertiliser demand, contributing to achieving the Sustainable Development Goals. However, organic wastes may contain contaminants of emerging concern (CECs), posing potential ecosystem and human health risks. Despite the importance of this issue, there is a lack
Felicity C. T. Elder, Jose‐Luis Fajardo‐Escoffié, Laura Carter, Emily K. Durant, Katie J. Field, John Nightingale, Brett Sallach, Andrea‐Lorena Garduño‐Jiménez   +7 more
wiley   +1 more source

In vitro biofilms and antifungal susceptibility of dermatophyte and non-dermatophyte moulds involved in foot mycosis [PDF]

, 2017
Tinea pedis and onychomycosis are among the commonest fungal diseases in the world. Dermatophytes and, less frequently, non-dermatophyte moulds are aetiological agents of foot mycosis and are capable of forming biofilms.
Bougnoux, Marie Élisabeth, Corpologno, Serena, El Euch, Dalenda, Sadfi-Zouaoui, Najla, Simonetti, Giovanna, Toukabri, Nourchéne   +5 more
core   +1 more source

Development of a physiologically‐based pharmacokinetic model for Ritonavir characterizing exposure and drug interaction potential at both acute and steady‐state conditions

CPT: Pharmacometrics &Systems Pharmacology, Volume 14, Issue 3, Page 523-539, March 2025.
Abstract Ritonavir (RTV) is a potent CYP3A inhibitor that is widely used as a pharmacokinetic (PK) enhancer to increase exposure to select protease inhibitors. However, as a strong and complex perpetrator of CYP3A interactions, RTV can also enhance the exposure of other co‐administered CYP3A substrates, potentially causing toxicity.
Lien Thi Ngo, Woojin Jung, Tham Thi Bui, Hwi‐yeol Yun, Jung‐woo Chae, Jeremiah D. Momper   +5 more
wiley   +1 more source