Flucytosine Pharmacokinetics in a Critically Ill Patient Receiving Continuous Renal Replacement Therapy [PDF]
Case Reports in Critical Care, 2015 Purpose. A case report evaluating flucytosine dosing in a critically ill patient receiving continuous renal replacement therapy. Summary. This case report outlines an 81-year-old male who was receiving continuous venovenous hemofiltration (CVVH) for ...
Megan E. Kunka +3 more
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Factors Influencing the Nitrogen-Source Dependent Flucytosine Resistance in Cryptococcus Species
mBio, 2023 Flucytosine (5-FC) is an antifungal agent commonly used for treatment of cryptococcosis and several other systemic mycoses. In fungi, cytosine permease and cytosine deaminase are known major players in flucytosine resistance by regulating uptake and ...
Dong-Hoon Yang +3 more
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A Pilot Study Showing Fluconazole and Flucytosine Activities against Candida glabrata are Affected by Low pH: Implications for the Treatment of Recurrent Vulvovaginal Candidiasis [PDF]
Clinical and Experimental Obstetrics & GynecologyBackground: Candida albicans (C. albicans) and Candida glabrata (C. glabrata) are mainly associated with vulvovaginal candidiasis (VVC). Management of VVC caused by C.
Ziauddin Khan +2 more
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Detection of FUR1 Gene in 5-Flucytosine Resistant Candida Isolates in Vaginal Candidiasis Patients [PDF]
Journal of Clinical and Diagnostic Research, 2013 Background and Aims: This study was done to detect the prevalence, risk factors for vaginal candidiasis in Chennai and to evaluate different methods for speciation of Candida isolates from vaginal candidiasis patients.
Sasikala Gopinathan +3 more
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Emergence of Flucytosine-Resistant Candida tropicalis Clade, the Netherlands [PDF]
Emerging Infectious DiseasesCandida tropicalis is the second most virulent Candida species after C. albicans. Previous studies from the Netherlands and France reported a notable reduction in susceptibility to flucytosine (5-FC) in a substantial proportion of C. tropicalis isolates.
Fatima Zohra Delma +10 more
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Impact of Biofilm Formation by Vaginal Candida albicans and Candida glabrata Isolates and Their Antifungal Resistance: A Comprehensive Study in Ecuadorian Women [PDF]
Journal of FungiCandida albicans and Candida glabrata are key fungal pathogens linked to candidiasis, with rising concerns due to antifungal resistance and biofilm abilities. However, data from Latin America remains limited.
Ariana Cecibel Cedeño-Pinargote +6 more
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Study on the impact of biofilm formation by Candida albicans in recurrent vulvovaginal candidiasis on drug susceptibility [PDF]
Frontiers in Cellular and Infection MicrobiologyBackgroundVulvovaginal candidiasis (VVC) and recurrent VVC (RVVC) are common fungal infections in women, often complicated by recurrence and treatment resistance.
Sainan Li +4 more
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Model‐Informed Drug Development of a Sustained Release Formulation of Flucytosine in the Treatment of Cryptococcal Meningitis: A Case Study Using Physiologically Based Pharmacokinetic Modeling [PDF]
CPT: Pharmacometrics & Systems PharmacologyThis paper presents a case study demonstrating the application of model‐informed drug development (MIDD) and early modeling integration in the development of a sustained release (SR) formulation of flucytosine for cryptococcal meningoencephalitis (CM) in
Johanna Eriksson +8 more
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Induction Treatment for HIV-Associated Cryptococcal Meningitis: Where Have We Been and Where Are We Going? [PDF]
MicroorganismsCryptococcal meningitis remains a leading cause of morbidity and mortality among individuals with HIV/AIDS, particularly in resource-limited settings. Treatment begins with induction therapy followed by consolidation and maintenance.
Dominique Milsap +7 more
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The silent flucytosine shortage in Europe – not a distant problem
The Lancet Regional Health. Europe, 2023 Rosanne Sprute +4 more
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