Limited Activity Of Miltefosine In Murine Models Of Cryptococcal Meningoencephalitis And Disseminated Cryptococcosis [PDF]
, 2013 Miltefosine is an alkyl phosphocholine with good oral bioavailability and in vitro activity against Cryptococcus species that has gained interest as an additional agent for cryptococcal infections.
Bocanegra, Rosie +5 more
core +1 more source
Eradication of Candida albicans persister cell biofilm by the membranotropic peptide gH625 [PDF]
, 2020 Biofilm formation poses an important clinical trouble due to resistance to antimicrobial agents; therefore, there is an urgent demand for new antibiofilm strategies that focus on the use of alternative compounds also in combination with conventional ...
D'Alterio, A. +8 more
core +1 more source
Quantitative and qualitative analysis of the antifungal activity of allicin alone and in combination with antifungal drugs. [PDF]
PLoS ONE, 2012 The antifungal activity of allicin and its synergistic effects with the antifungal agents flucytosine and amphotericin B (AmB) were investigated in Candida albicans (C. albicans). C.
Young-Sun Kim +5 more
doaj +1 more source
Antifungal Combinations for Treatment of Cryptococcal Meningitis in Africa [PDF]
, 2018 Background Cryptococcal meningitis accounts for more than 100,000 human immunodeficiency virus (HIV)–related deaths per year. We tested two treatment strategies that could be more sustainable in Africa than the standard of 2 weeks of amphotericin B ...
ACTA Trial Study Team +37 more
core +5 more sources
Journal of Fungi, 2021 This study was designed to analyze the interaction of 21 antifungal combinations consisting of seven major antifungal agents against 11 echinocandin- susceptible and six-resistant C. glabrata isolates. The combinations were divided into five major groups
Hazim O. Khalifa +3 more
doaj +1 more source
Cryptococcal meningitis : epidemiology and therapeutic options [PDF]
, 2018 Cryptococcal meningitis causes morbidity and mortality worldwide. The burden of disease is greatest in middle- and low-income countries with a high incidence of human immunodeficiency virus (HIV infection. Patients taking immunosuppressive drugs and some
Parris, Victoria, Sloan, Derek J.
core +1 more source
Does DHN-Melanin Always Protect Fungi against Antifungal Drugs? The Fonsecaea/Micafungin Paradigm
Microbiology Research, 2022 Several human pathogenic fungi produce melanin. One of its properties during parasitism is the protection against antifungal drugs. This occurs with the agents of chromoblastomycosis, in which DHN-melanin reduces antifungal susceptibility to terbinafine ...
Rowena Alves Coelho +7 more
doaj +1 more source
Fungal infections of the central nervous system: A review of fungal pathogens and treatment [PDF]
, 2007 Multiple factors influence the outcome of fungal infection of the central nervous system (CNS). The host and the pathogen in concert with drug delivery across the blood-brain barrier and drug activity are key factors in outcome.
Dancer, C., Redmond, A., Woods, M. L.
core +1 more source
Quantitative and qualitative analyses of the cell death process in Candida albicans treated by antifungal agents. [PDF]
PLoS ONE, 2011 The death process of Candida albicans was investigated after treatment with the antifungal agents flucytosine and amphotericin B by assessing morphological and biophysical properties associated with cell death. C.
Kyung Sook Kim +5 more
doaj +1 more source
Recent advances in managing HIV-associated cryptococcal meningitis [PDF]
, 2019 The recent development of highly sensitive and specific point-of-care tests has made it possible to diagnose HIV-associated cryptococcal meningitis within minutes.
Alanio, A +5 more
core +2 more sources