Results 51 to 60 of about 13,152 (241)

Toxicity of Amphotericin B Deoxycholate-Based Induction Therapy in Patients with HIV-Associated Cryptococcal Meningitis. [PDF]

, 2015
Amphotericin B deoxycholate (AmBd) is the recommended induction treatment for HIV-associated cryptococcal meningitis (CM). Its use is hampered by toxicities that include electrolyte abnormalities, nephrotoxicity, and anemia.
Bicanic, T, Bottomley, C, Brouwer, AE, Harrison, TS, Hosseinipour, MC, Jackson, A, Jarvis, JN, Limmathurotsakul, D, Loyse, A, Meintjes, G, Muzoora, C, Phulusa, J, Taseera, K, van der Horst, C, White, NJ, Wilson, D, Wood, R   +16 more
core   +2 more sources

A Report on the Diagnosis and Treatment of Multiple Fungal Critical Brain Abscesses A Case Report

Clinical Case Reports, Volume 14, Issue 1, January 2026.
ABSTRACT Multiple Candida glabrata (C. glabrata) brain abscesses are an exceptionally rare central‐nervous‐system infection. Clinical data on diagnosing and managing multiple Candida glabrata brain abscesses are still scarce. Here we reported a 66‐year‐old patient with multiple C. glabrata brain abscesses confirmed by cerebrospinal‐fluid puncture.
Chongyin Zhang, Dayong Deng, Xiaoning Gao, Lei Yang, Fengzi Yao   +4 more
wiley   +1 more source

Polymorphic α‐Glucans as Structural Scaffolds in Cryptococcus Cell Walls for Chitin, Capsule, and Melanin: Insights From 13C and 1H Solid‐State NMR

Angewandte Chemie, Volume 137, Issue 36, September 1, 2025.
Cryptococcus neoformans cell wall α‐1,3‐glucans as dual anchors for melanin and capsule: Solid‐state NMR of intact C. neoformans cells reveals five forms of α‐1,3‐glucans that structurally bridge melanin and capsule layers. These polysaccharides interact with chitin, chitosan, and β‐glucans to create a molecular scaffold that underlies virulence and ...
Ankur Ankur, Jayasubba Reddy Yarava, Isha Gautam, Faith J. Scott, Frederic Mentink‐Vigier, Christine Chrissian, Li Xie, Dibakar Roy, Ruth E. Stark, Tamara L. Doering, Ping Wang, Tuo Wang   +11 more
wiley   +2 more sources

Healthcare Costs and Life-years Gained From Treatments Within the Advancing Cryptococcal Meningitis Treatment for Africa (ACTA) Trial on Cryptococcal Meningitis: A Comparison of Antifungal Induction Strategies in Sub-Saharan Africa [PDF]

, 2019
Background Mortality from cryptoccocal meningitis remains high. The ACTA trial demonstrated that, compared with 2 weeks of amphotericin B (AmB) plus flucystosine (5FC), 1 week of AmB and 5FC was associated with lower mortality and 2 weeks of oral ...
Adrian Gheorghe, Adrienne K Chan, Angela Loyse, Barber, Bilinski, Brouwer, Cecilia Kanyama, Charles Kouanfack, Drummond, Duncan Chanda, Elvis Temfack, Gaskell, Gravelle, Griffiths, Horton, Husereau, Lawrence Mwenge, Lin, Longley, Louis W Niessen, Mills, Mina C Hosseinipour, Molloy, Mueller, Olivier Lortholary, Perfect, Peter Mwaba, Rajasingham, Rajasingham, Robert S Heyderman, Rothe, Sayoki Mfinanga, Sculpher, Shabbar Jaffar, Shabir Lakhi, Sokoine Kivuyo, Síle F Molloy, Tao Chen, Thomas S Harrison, Ulla K Griffiths   +39 more
core   +3 more sources

Global Investigation of Clinical Implementation Strategies for DPYD Testing to Guide Fluoropyrimidine Therapy

Clinical and Translational Science, Volume 19, Issue 1, January 2026.
ABSTRACT Fluoropyrimidines are a vital component of chemotherapy regimens. Deleterious DPYD variants reduce activity of dihydropyrimidine dehydrogenase, the rate‐limiting enzyme of fluoropyrimidine catabolism, resulting in reduced fluoropyrimidine clearance and elevated risk of life‐threatening toxicities.
Nihal El Rouby, Christina L. Aquilante, Salma A. Bargal, Larisa H. Cavallari, Julio D. Duarte, Kelly Gunderson, Tinashe Mazhindu, Mohamed Nagy, Xiaoyan Nie, D. Grace Nguyen, Jai N. Patel, Todd C. Skaar, D. Max Smith, Sony Tuteja, Ron H. N. van Schaik, J. Kevin Hicks, on behalf of The PGRN Implementation Working Group, Josiah Allen, Chad Bousman, Amber Cipriani, Amanda Elchynnski, Philip Empey, Ashley Fleck, Teresa Ho, Lauren Lemke, Nita Limdi, Pawel Mroz, Rocio Ortiz‐Lopez, Aniwaa Owusu Obeng, Amy Pasternak, April Schultz, James Stevenson, Ayah Ziyada, Elanie Lo   +33 more
wiley   +1 more source

Symptomatic Cryptococcal Meningitis with Negative Serum and Cerebrospinal Fluid Cryptococcal Antigen Tests

HIV/AIDS: Research and Palliative Care, 2021
Vivien Nanfuka,1,* Mkhoi L Mkhoi,2– 4,* Jane Gakuru,2 Richard Kwizera,2 Joseph Baruch Baluku,5 Felix Bongomin,6,7 David B Meya1,2,6 1Infectious Diseases Unit, Kiruddu National Referral Hospital, Kampala, Uganda; 2Infectious Diseases Institute ...
Nanfuka V, Mkhoi ML, Gakuru J, Kwizera R, Baluku JB, Bongomin F, Meya DB   +6 more
doaj  

Persistent Cryptococcal Brain Infection despite Prolonged Immunorecovery in an HIV-Positive Patient. [PDF]

, 2014
Background. HIV-positive people starting combined antiretroviral therapy may develop immune reconstitution to latent or treated opportunistic infections. Immune reconstitution to cerebral Cryptococcus is poorly understood and can be fatal.
Baxter, Jo, Blanchard, Tom J, du Plessis, Daniel, Herwadkar, Amit, Javier Vilar, F, Varma, Anoop, Wingfield, Tom   +6 more
core   +2 more sources

A Cross‐Sectional Study to Determine Candida spp. Carriage in Libyan Patients With Type 2 Diabetes

BioMed Research International, Volume 2026, Issue 1, 2026.
The risk for Candida infections in patients with diabetes mellitus (DM) is three times higher than in the general population. Despite a DM prevalence of 15.8% reported in Libya (2024), the laboratory identification and susceptibility testing of fungal infections in patients with DM are not routinely performed.
Mustafa H. M. Esmaio, Pedro M. D. S. Abrantes, Charlene W. J. Africa, Mohsin Khurshid   +3 more
wiley   +1 more source

Cryptococcal meningitis: improving access to essential antifungal medicines in resource-poor countries [PDF]

, 2013
Cryptococcal meningitis is the leading cause of adult meningitis in sub-Saharan Africa, and contributes up to 20% of AIDS-related mortality in low-income and middle-income countries every year.
Bicanic, Tihana, Chiller, Tom, Easterbrook, Philippa, Ford, Nathan, Govender, Nelesh, Harrison, Thomas S, Loyse, Angela, Roy, Monika, Thangaraj, Harry   +8 more
core   +1 more source

Multicenter, International Study of MIC/ MEC Distributions for definition of epidemiological cutoff values for sporothrix species identified by molecular methods [PDF]

, 2017
Clinical and Laboratory Standards Institute (CLSI) conditions for testing the susceptibilities of pathogenic Sporothrix species to antifungal agents are based on a collaborative study that evaluated five clinically relevant isolates of Sporothrix ...
Abreu, D.P.B., Almeida-Paes, R., Ballesté Alaniz, R., Bonfietti, L.X., Bonifaz, A., Brilhante, R.S.N., Chakrabarti, A., Chowdhary, A., Córdoba, S., Espinel-Ingroff, A., et al., Gonzalez, G.M., Govender, N.P., Guarro, J., Hagen, F., Johnson, E.M., Kidd, S., Pereira, S.A., Rodrigues, A.M., Rozental, S., Szeszs, M.W.   +20 more
core   +1 more source