Results 61 to 70 of about 13,152 (241)

Non‐albicans Candida in Vulvovaginal Candidiasis: Antifungal Resistance and Expression of ERG11, CDR1, CDR2, and MDR1 Genes

MicrobiologyOpen, Volume 14, Issue 6, December 2025.
The rise in azole resistance among Nakaseomyces glabratus and Pichia kudriavzevii presents a growing public health challenge. These results indicate that even in cases where an isolate is classified as susceptible by drug susceptibility testing, elevated gene expression may persist, and treatment should not be discontinued.
Fatemeh Zahra Ranjbar Golafshani, Firoozeh Kermani, Soheila Abbaszadeh Godarzi, Saeid Mahdavi Omran   +3 more
wiley   +1 more source

Formulation and evaluation of flucytosine-loaded nanoemulgel for enhanced antifungal activity through in vitro and in vivo studies

Journal of Applied Pharmaceutical Research
Background: Fungal skin infections constitute a prevalent global health issue, accompanied by increasing resistance to traditional antifungal medications.
Rajat Srivastava, Ajay Kumar Singh Rawat   +1 more
doaj   +1 more source

Antifungal Resistance of Candida spp. Isolates From HIV/AIDS Patients in Iran 1999–2024: A Systematic Review and Meta‐Analysis

Journal of Clinical Laboratory Analysis, Volume 39, Issue 21, November 2025.
Antimicrobial resistance in Candida spp. is significant in individuals with HIV/AIDS infections, particularly in Iran. In this systematic review, a comprehensive systematic search was conducted to identify all the eligible studies between 1999 and 2024; the pooled resistance rates of Candida spp. against antimicrobial agents were estimated. The risk of
Aliasghar Fakhri‐Demeshghieh, Ali Yousefipour, Yousef Bolouki, Mohammad Sadegh Bigdeli, Erfan Zamani, Amirreza Farajkhoda, Alireza Salmani, Farzad Katiraee, Saied Bokaie   +8 more
wiley   +1 more source

Antifungal susceptibilities of Cryptococcus species complex isolates from AIDS and non-AIDS patients in Southeast China

Brazilian Journal of Infectious Diseases, 2012
Cryptococcus spp. are common causes of mycoses in immunocompromised patients. To determine the drug susceptibilities of clinical Cryptococcus spp. isolates, the characteristics of 61 clinical Cryptococcus spp.
Meng Li, Yong Liao, Min Chen, Weihua Pan, Lixing Weng   +4 more
doaj   +1 more source

Enhancement of antifungal activity and transdermal delivery of 5-flucytosine via tailored spanlastic nanovesicles: statistical optimization, in-vitro characterization, and in-vivo biodistribution study

Frontiers in Pharmacology, 2023
Aim and background: This current study aimed to load 5-flucytosine (5-FCY) into spanlastic nanovesicles (SPLNs) to make the drug more efficient as an antifungal and also to load the 5-FCY into a hydrogel that would allow for enhanced transdermal ...
Awaji Y. Safhi, Nimbagal Raghavendra Naveen, Krishna Jayanth Rolla, Penmetsa Durga Bhavani, Mallesh Kurakula, Khaled M. Hosny, Walaa A. Abualsunun, Mohammed Alissa, Abdullah Alsalhi, Amerh Aiad Alahmadi, Khalid Zoghebi, Abdulrahman Sindam Halwaani, Rasha Ibrahim K   +12 more
doaj   +1 more source

Candida infections, causes, targets and resistance mechanisms. Traditional and alternative antifungal agents [PDF]

, 2013
The genus Candida includes about 200 different species, but only a few species are human opportunistic pathogens and cause infections when the host becomes debilitated or immunocompromised. Candida infections can be superficial or invasive.
Leonardi, Darío, Spampinato, Claudia Patricia   +1 more
core   +3 more sources

Antifungal Resistance and Synergistic Therapy in Candida Spp. Isolated From Bottlenose Dolphins Under Human Care: Implications for One Health Management

Veterinary Medicine and Science, Volume 11, Issue 6, November 2025.
Candida spp. isolated from bottlenose dolphins under human care showed multirug resistance to common azoles. In vitro synergy testing revealed that certain antifungal combinations improved efficacy against resistant strains. Environmental monitoring using FISH detected Candida spp.
Barbara Biancani, Federica Mauri, Francesco Di Nezio, Diana Binanti, Stefano Furlati, Samuele Roman, Giorgia Matteucci   +6 more
wiley   +1 more source

Insights into Candida tropicalis nosocomial infections and virulence factors [PDF]

, 2012
Candida tropicalis is considered the first or the second non-Candida albicans Candida (NCAC) species most frequently isolated from candidosis, mainly in patients admitted in intensive care units (ICUs), especially with cancer, requiring prolonged ...
A Bedini, A Chakrabarti, A Prakobphol, AF Shorr, AJ Carey, AL Colombo, AL Colombo, AM Tortorano, AM Tortorano, AS Kantarciôlu, B Hota, C Bendel, C Cafarchia, C Kumar, C Lass-Flörl, C Paulo, C Schabereiter-Gurtner, C Zaugg, CA Binelli, CA Kauffman, CA Kumamoto, CI Bustamante, CM Bendel, CP Kurtzman, D HO, D Larone, DA Kliemann, DB Shurtleff, DR Snydman, DW Williams, E Dorko, EH Silva, EHd Silva, EM Kojic, EM Mokaddas, F Gotz, F Hasan, F Álvarez-Lerma, FC Bizerra, G Butler, G Dimopoulos, G Liguori, G Luo, G Pappas Peter, HC Chang, J Jayatilake, J Loeffler, J Rho, J Zhang, JM Achkar, JM Manns, JR Blankenship, JR Naglik, K Costa da, K Sohn, L Furlaneto-Maia, LJ Douglas, LL Hoyer, M Arendrup, M Bassetti, M Desnos-Ollivier, M Meric, M Miyauchi, M Negri, M Negri, M Negri, M Nucci, M Nucci, M Nucci, M Price, M-F Cheng, M. Henriques, M. Negri, MA Al-Fattani, MA Galan-Ladero, MA Ghannoum, MA Pfaller, MA Pfaller, MA Pfaller, MA Pfaller, ME Bougnoux, ME Falagas, MS Biasoli, MS Biasoli, MV Martin, N Jain, N Paul, NK Tamura, O Gudlaugsson, O Yoshio, P Eggimann, P Kontoyiannis Dimitrios, P Viale, P-R Hsueh, R Cisterna, R. Oliveira, RA Calderone, RJ Bennett, RJ Kothavade, RS Al-Dhaheri, S Basu, S Fricke, S Oksuz, S Silva, S Silva, S Silva, S Silva, S. Silva, SA Klotz, T Kanbe, T Lundstrom, T Watanabe, V Krcmery, V Krcmery, VG Kumar, VJ Krcmery, Y Fu, Y Okawa, Y Yang   +118 more
core   +1 more source

Repositioning Antimicrobial Peptides Against WHO‐Priority Fungi

Advanced Science, Volume 12, Issue 37, October 6, 2025.
The growing burden of drug‐resistant fungal infections, driven by pathogens such as Candida auris, Cryptococcus neoformans, and Aspergillus fumigatus, underscores the urgent need for novel antifungal therapies. This review explores antimicrobial peptides as promising agents with membrane‐disruptive activity, immunomodulatory properties, and delivery ...
Cesar Augusto Roque‐Borda, Kaila Petronila Medina‐Alarcón, João Paulo Soler Gonçalves Pereira, Thais Cristina dos Anjos Sevilhano, Brigitte Aguilar‐Morón, Fernando Díaz‐Cárdenas, Lucas Silva da Cruz, Francisco Humberto Xavier‐Júnior, Eduardo Festozo Vicente, João Perdigão, Beatriz G. de la Torre, Fernando Albericio, Fernando Rogério Pavan   +12 more
wiley   +1 more source

Rapid in vitro evolution of flucytosine resistance in Candida auris

mSphere
The pan-antifungal-resistant pathogen Candida auris has been causing high-mortality infection outbreaks in hospitals and healthcare settings. The prodrug 5-fluorocytosine (5FC) is one of four chemical entities, but its clinical use as an antifungal drug ...
Trinh Phan-Canh, Duc-Minh Nguyen-Le, Phuc-Loi Luu, Narakorn Khunweeraphong, Karl Kuchler   +4 more
doaj   +1 more source