Results 21 to 30 of about 8,686 (179)

Glucocorticoids with or without fludrocortisone in septic shock: a narrative review from a biochemical and molecular perspective

British Journal of Anaesthesia, 2023
Summary Two randomised controlled trials have reported a reduction in mortality when adjunctive hydrocortisone is administered in combination with fludrocortisone compared with placebo in septic shock.
G. Nethathe, Jeffrey Lipman, Ronald Anderson, Peter J. Fuller, C. Feldman   +4 more
semanticscholar   +1 more source

Do We Need to Administer Fludrocortisone in Addition to Hydrocortisone in Adult Patients With Septic Shock? An Updated Systematic Review With Bayesian Network Meta-Analysis of Randomized Controlled Trials and an Observational Study With Target Trial Emulation*

Critical Care Medicine, 2023
OBJECTIVES: This systematic review and Bayesian network meta-analysis evaluated the efficacy and safety of hydrocortisone combined with fludrocortisone or hydrocortisone alone, compared with placebo in adult patients with septic shock.
P. Lai, Chao-Han Lai, E. C. Lai, Yen-Ta Huang   +3 more
semanticscholar   +1 more source

Primary adrenal insufficiency - Addison's disease

Journal of Education, Health and Sport, 2022
Introduction and purpose Addison's syndrome is defined as primary adrenal insufficiency, the symptoms of which result from hormonal deficiencies: glucocorticosteroids, mineralocorticosteroids and androgens.
Jakub Metelski, Aleksandra Metelska, Dominika Sereda, Hubert Nieścior, Monika Szwed   +4 more
doaj   +1 more source

Hydrocortisone dosing in children with classic congenital adrenal hyperplasia: results of the German/Austrian registry

Endocrine Connections, 2021
Objective: Treatment of classic congenital adrenal hyperplasia (CAH) is necessary to compensate for glucocorticoid/mineralocorticoid deficiencies and to suppress androgen excess.
Heike Hoyer-Kuhn, Angela Huebner, Anette Richter-Unruh, Markus Bettendorf, Tilman Rohrer, Klaus Kapelari, Stefan Riedl, Klaus Mohnike, Helmuth-Günther Dörr, Friedrich-Wilhelm Roehl, Katharina Fink, Reinhard W Holl, Joachim Woelfle   +12 more
doaj   +1 more source

Renin and electrolytes indicate the mineralocorticoid activity of fludrocortisone: a 6 year study in primary adrenal insufficiency

Journal of Endocrinological Investigation, 2022
Context Fludrocortisone (FC) is the mineralocorticoid (MC) replacement treatment for patients with primary adrenal insufficiency (PAI). Objective To explore the dose of FC treatment and its relationship with glucocorticoid therapy, sodium, potassium ...
F. Ceccato, M. Torchio, I. Tizianel, M. Peleg Falb, M. Barbot, C. Sabbadin, C. Betterle, C. Scaroni   +7 more
semanticscholar   +1 more source

Ambulatory fludrocortisone suppression test in the diagnosis of primary aldosteronism: Safety, accuracy and cost‐effectiveness

Clinical Endocrinology, 2022
The aims of this study were to explore if the ambulatory fludrocortisone suppression test (FST) was safe, accurate and cost‐effective.
Ana Carasel, J. Calissendorff, Kamila Avander, I. Shabo, C. Volpe, H. Falhammar   +5 more
semanticscholar   +1 more source

Conventional Vasopressor and Vasopressor‐Sparing Strategies to Counteract the Blood Pressure–Lowering Effect of Small Interfering RNA Targeting Angiotensinogen

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2022
Background A single dose of small interfering RNA (siRNA) targeting liver angiotensinogen eliminates hepatic angiotensinogen and lowers blood pressure.
Estrellita Uijl, Dien Ye, Liwei Ren, Katrina M. Mirabito Colafella, Richard van Veghel, Ingrid M. Garrelds, Hong S. Lu, Alan Daugherty, Ewout J. Hoorn, Paul Nioi, Don Foster, A. H. Jan Danser   +11 more
doaj   +1 more source

Use of fludrocortisone for intradialytic hypotension

Kidney Research and Clinical Practice, 2018
Intradialytic hypotension during dialysis adversely affects a patient's prognosis and increases mortality. We report a case in which intradialytic hypotension that persisted after the administration of midodrine was relieved after the use of ...
Yuri Seo, Soomin Jeung, Sun-myoung Kang, Won Seok Yang, Hyosang Kim, Soon Bae Kim   +5 more
doaj   +1 more source

Anti-inflammatory and neuroprotective properties of the corticosteroid fludrocortisone in retinal degeneration.

Experimental Eye Research, 2021
The pathogenesis of outer retinal degenerations has been linked to the elevation of cytokines that orchestrate pro-inflammatory responses within the retinal milieu, and which are thought to play a role in diseases such as geographic atrophy (GA), an ...
Tanja Racic, A. Chang, Nilisha Fernando, Alice Brandli, R. Natoli, P. Penfold, J. Provis, Matt Rutar   +7 more
semanticscholar   +1 more source

Combination of low-dose glucocorticosteroids and mineralocorticoids as adjunct therapy for adult patients with septic shock: A systematic review and meta-analysis of randomized trials and observational studies

Avicenna Journal of Medicine, 2019
Background: The role of the combination of glucocorticosteroids and mineralocorticosteroids in treating septic shock is not well-defined. The aim of this study was to perform a systematic review and meta-analysis of the randomized controlled trials and ...
Paraschos Archontakis Barakakis, Leonidas Palaiodimos, Derlis Fleitas Sosa, Linda Benes, Perminder Gulani, Daniel Fein   +5 more
doaj   +1 more source