Results 41 to 50 of about 6,146 (158)

Mineralocorticoid receptor stimulation induces urinary storage dysfunction via upregulation of epithelial sodium channel expression in the rat urinary bladder epithelium

open access: yesJournal of Pharmacological Sciences, 2016
We aimed to evaluate mineralocorticoid receptor (MR) expression in rat bladder and the physiological role of the MR-epithelial sodium channel (ENaC) pathway in controlling bladder function in 10–12-week-old, male Sprague–Dawley rats.
Seiji Yamamoto   +9 more
doaj   +1 more source

Evaluation of the role of hydrocortisone either alone or combined with fludrocortisone in the outcome of septic shock in adults

open access: yesAin Shams Journal of Anesthesiology, 2022
Background Management of sepsis is a time critical procedure; the consequences of improperly managed sepsis and septic shock can cause multiple organ dysfunction and death.
Heba A. Labib   +4 more
doaj   +1 more source

Long‐term outcomes in patients with postural orthostatic tachycardia syndrome with an average follow‐up of over 20 years

open access: yesJournal of Internal Medicine, Volume 300, Issue 3, Page 299-311, September 2026.
Abstract Background Postural orthostatic tachycardia syndrome (POTS) is a chronic form of orthostatic intolerance that primarily affects female patients. There are scarce data evaluating the long‐term outcomes in POTS. Objectives This study sought to evaluate the long‐term impacts of POTS over multiple decades in adult patients.
Kate M. Bourne   +11 more
wiley   +1 more source

Efficacy and Safety of Corticosteroids in Tuberculous Meningitis: Systematic Review, Meta‐Analysis, and Meta‐Regression

open access: yesBrain and Behavior, Volume 16, Issue 8, August 2026.
ABSTRACT Background Tuberculous meningitis (TBM) carries a case fatality rate of up to 50% in resource‐limited settings despite standard anti‐tuberculosis therapy. Adjunctive corticosteroids are widely recommended, yet their effect on mortality and safety across diverse populations remains imprecisely defined.
Ayesha Younas   +14 more
wiley   +1 more source

Delay in Diagnosis of Addison's Disease: A Case Report and Literature Review

open access: yesClinical Case Reports, Volume 14, Issue 8, August 2026.
Graphic highlighting the timeline of ED visits and admissions for the case patient. ABSTRACT Primary adrenal insufficiency is a rare disorder prone to delay in diagnosis after initial presentation. Multiple factors including a wide range of presentations, slow onset of symptoms, and other human factors may be contributing to challenges with the ...
Ishita Bhattacharya   +2 more
wiley   +1 more source

Clinical Practice Guideline for Evaluation and Management of Peripheral Nervous System Manifestations in Sjögren's Disease

open access: yesArthritis Care &Research, Volume 78, Issue 7, Page 860-874, July 2026.
Objective Sjögren's disease is an autoimmune disorder that can impact multiple organ systems, including the peripheral nervous system (PNS). PNS manifestations, which can exist concurrently, include mononeuropathies, polyneuropathies, and autonomic nervous system neuropathies.
Anahita Deboo   +88 more
wiley   +1 more source

Resolution of Levodopa/Dopa‐Decarboxylase Inhibitor—Associated Microscopic Colitis with Subcutaneous Foslevodopa/Foscarbidopa: A Case Series and Review of the Literature

open access: yesMovement Disorders Clinical Practice, Volume 13, Issue 7, Page 1730-1739, July 2026.
Abstract Background Microscopic colitis (MC) typically presents with chronic, non‐bloody watery diarrhea. Diagnosis requires endoscopy with colonic mucosal biopsies. The etiology is multifactorial, with several medications implicated, although only a few cases have been attributed to oral levodopa/dopa‐decarboxylase inhibitor (LDDCI) therapy.
Romana Hintner   +10 more
wiley   +1 more source

Co-existence of Congenital Adrenal Hyperplasia and Familial Hypokalemic Periodic Paralysis due to CYP21A2 and SCN4A Pathogenic Variants

open access: yesJCRPE, 2021
Steroid 21-hydroxylase deficiency is the most common cause of congenital adrenal hyperplasia (CAH), usually due to biallelic variants in CYP21A2. Classical 21-hydroxylase deficiency is characterised by virilisation of the external genitalia in females ...
Tuğba Kontbay, İhsan Turan
doaj   +1 more source

Cerebral Salt Wasting Syndrome following Head Injury in a Child Managed Successfully with Fludrocortisone

open access: yesCase Reports in Pediatrics, 2016
Cerebral salt wasting (CSW) syndrome is an important cause of hyponatremia in head injuries apart from syndrome of inappropriate antidiuretic hormone (SIADH). Proper diagnosis and differentiation between these two entities are necessary for management as
Nagendra Chaudhary   +3 more
doaj   +1 more source

Stereoselective Production of Fluorohydrins Biocatalyzed by an Alcohol Dehydrogenase From Pichia glucozyma

open access: yesChemCatChem, Volume 18, Issue 11, 15 June 2026.
Ketoreductase from Pichia glucozyma (KRED1‐Pglu) has been successfully employed for the stereoselective bioreduction of α‐halogenated ketones using the purified protein, or alternatively a lyophilized whole cell preparation overexpressed in E. coli. Better chemoselectivities were found with pure biocatalyst, obtaining a series of chiral fluorohydrins ...
Marina García‐Ramos   +4 more
wiley   +1 more source

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