Results 51 to 60 of about 8,621 (184)

Current Screening Strategies for the Diagnosis of Adrenal Insufficiency in Children

Pediatric Health, Medicine and Therapeutics, 2023
Sasigarn A Bowden Division of Endocrinology, Department of Pediatrics, Nationwide Children’s Hospital/The Ohio State University College of Medicine, Columbus, OH, USACorrespondence: Sasigarn A Bowden, Nationwide Children’s Hospital, Division of ...
Bowden SA
doaj  

Combined Effects of Depression, Fatigue and Cardiovascular Dysfunction on Functional Dependence Over Seven Years in Early Parkinson's Disease

Movement Disorders Clinical Practice, EarlyView.
Abstract Background Parkinson's disease (PD) is associated with both motor and non‐motor symptoms, which collectively impact activities of daily living (ADLs) and contribute to the loss of functional independence. There is a lack of understanding of how non‐motor symptoms drive this loss in independence.
Charlotte B. Stewart, Sahana Sathyanarayana, Victoria K. Foster, Robyn Iredale, Debra Galley, Jacopo Pasquini, Kirstie N. Anderson, Nicola Pavese, David Ledingham   +8 more
wiley   +1 more source

Mineralocorticoid receptor stimulation induces urinary storage dysfunction via upregulation of epithelial sodium channel expression in the rat urinary bladder epithelium

Journal of Pharmacological Sciences, 2016
We aimed to evaluate mineralocorticoid receptor (MR) expression in rat bladder and the physiological role of the MR-epithelial sodium channel (ENaC) pathway in controlling bladder function in 10–12-week-old, male Sprague–Dawley rats.
Seiji Yamamoto, Yuji Hotta, Kotomi Maeda, Tomoya Kataoka, Yasuhiro Maeda, Takashi Hamakawa, Shoichi Sasaki, Takahiro Yasui, Kiyofumi Asai, Kazunori Kimura   +9 more
doaj   +1 more source

The Evolving Landscape of Immunotoxicity: Charting Mechanisms and Future Strategies for Immune Checkpoint Inhibitor Adverse Events

Med Research, EarlyView.
ABSTRACT The use of immune checkpoint inhibitors (ICIs) has significantly improved the efficacy of cancer therapy, but their associated immune‐related adverse events (irAEs) can severely compromise treatment safety. This review systematically summarizes the core mechanisms underlying irAEs, which include multi‐organ damage resulting from T‐cell ...
Anqi Lin, Keyin Zheng, Aimin Jiang, Xufeng Huang, Qi Wang, András Hajdu, Zhengrui Li, Jian Zhang, Peng Luo   +8 more
wiley   +1 more source

Fludrocortisone Therapy in Renal Transplant Recipients with Persistent Hyperkalemia

Case Reports in Transplantation, 2012
Hyperkalemia after kidney transplantation is a common electrolyte disturbance and the risk factors are multifactorial. Pharmacotherapeutic agents for chronic management of hyperkalemia in kidney transplant patients may be relatively contraindicated or ...
K. Marfo, D. Glicklich
doaj   +1 more source

Cardiovascular Health in Women—Across the Lifespan

Clinical Endocrinology, EarlyView.
ABSTRACT Cardiovascular disease (CVD) remains the leading cause of mortality and morbidity among women worldwide. However, CVD continues to be perceived as a predominantly male issue. CVD in women therefore remains understudied, underrecognized and undertreated.
Jaya Chandrasekhar, Jessica Yao, Simone Gong, Madhuka Wijayarathne, Monique Watts, Swati Mukherjee   +5 more
wiley   +1 more source

Co-existence of Congenital Adrenal Hyperplasia and Familial Hypokalemic Periodic Paralysis due to CYP21A2 and SCN4A Pathogenic Variants

JCRPE, 2021
Steroid 21-hydroxylase deficiency is the most common cause of congenital adrenal hyperplasia (CAH), usually due to biallelic variants in CYP21A2. Classical 21-hydroxylase deficiency is characterised by virilisation of the external genitalia in females ...
Tuğba Kontbay, İhsan Turan
doaj   +1 more source

Sleep Architecture Alterations Following High‐Dose Steroid Pulse Therapy: A Pilot Study Using a Portable Electroencephalogram‐Based Device

Neuropsychopharmacology Reports, Volume 45, Issue 4, December 2025.
High‐dose steroid pulse therapy markedly reduces total sleep time, REM, and NREM sleep, as objectively demonstrated for the first time using a portable EEG‐based device. ABSTRACT Background Sleep disturbance is a common side effect of high‐dose steroid pulse therapy (SPT).
Hiroki Endo, Yuki Shigetsura, Misaki Chahara, Keisuke Kido, Etsuro Nakanishi, Sakiho Ueda, Kimitoshi Kimura, Akira Kuzuya, Hirotsugu Kawashima, Riki Matsumoto, Masahiro Tsuda, Shunsaku Nakagawa, Tomohiro Terada   +12 more
wiley   +1 more source

Exenatide Once Weekly in the Treatment of Patients with Multiple System Atrophy

Annals of Neurology, Volume 98, Issue 5, Page 991-1003, November 2025.
Objective Exenatide, a glucagon‐like peptide‐1 (GLP‐1) receptor agonist, has neuroprotective effects in preclinical models of multiple system atrophy (MSA). We investigated these effects in a proof‐of‐concept clinical trial. Methods In this single‐center, randomized, open label trial, participants with MSA were randomly assigned (1:1) to receive ...
Nirosen Vijiaratnam, Christine Girges, Martin Wiegand, Claudia Ismail, Alexandra Lameirinhas, Alison Yarnall, Cameron Kirk, Silvia Del‐Din, Lynn Rochester, Christopher Kobylecki, Gareth Ambler, Simon Skene, Henry Houlden, Viorica Chelban, Amanda Heslegrave, Wendy Phillips, Alan Whone, Niall Quinn, Christian Lambert, Charlotte Dore, Huw R. Morris, Mathew H. Horrocks, Ji Eun Lee, Judi O'Shaughnessy, Yazhou Li, Nigel H. Greig, Sonia Gandhi, Vincenzo Libri, Dilan Athauda, Tom Foltynie   +29 more
wiley   +1 more source

Use of Fludrocortisone for Hyperkalemia in Chronic Kidney Disease Not Yet on Dialysis

Electrolytes & Blood Pressure
Background Hyperkalemia is a frequent and potentially lethal complication of chronic kidney disease (CKD). We retrospectively examined the potassium-lowering effect of oral fludrocortisone and its adverse effects in hyperkalemic CKD patients not yet on ...
Eun Kyoung Lee, Won Seok Yang
semanticscholar   +1 more source