Patient Experience of Flunarizine for Vestibular Migraine: Single Centre Observational Study [PDF]
Brain Sciences, 2022 Vestibular migraine (VM) is a leading cause of episodic vertigo, affecting up to 1% of the general population. Despite established diagnostic criteria, there is currently no evidence-based approach for acute treatment of VM, with treatment ...
Sk Mamun Ur Rashid +4 more
doaj +11 more sources
Protective Effects of Adenosine Triphosphate and Flunarizine on Erlotinib-Induced Ovarian Damage: An Experimental Study [PDF]
Life(1) Background: Erlotinib is a tyrosine kinase inhibitor (TKI) widely used in cancer therapy; however, its potential adverse effects on ovarian tissue have not been fully elucidated. The present study aimed to investigate erlotinib-induced ovarian injury
Arzu Yavuz +7 more
doaj +2 more sources
Flunarizine changes microRNA expression in cell cultures and in a mouse model of spinal muscular atrophy [PDF]
Scientific ReportsSpinal muscular atrophy (SMA) is caused by mutations in the Survival Motor Neuron 1 (SMN1) gene, leading to reduced SMN protein levels and widespread disruption in RNA metabolism.
Emeline Bon +7 more
doaj +2 more sources
Flunarizine attenuates ischemia–reperfusion–induced ovarian injury in rats [PDF]
Journal of Ovarian ResearchBackground Ovarian ischemia–reperfusion (I/R) injury is associated with oxidative stress, inflammation, and histopathological damage. The aim of this study was to investigate the potential protective effects of flunarizine against ovarian I/R–induced ...
Arzu Yavuz +6 more
doaj +2 more sources
Targeting Oxidative Stress and Inflammation in Pembrolizumab-Induced Renal Injury: A Comparative Evaluation of the Protective Effects of Flunarizine and Carvacrol in Rats [PDF]
BiomoleculesBackground: Pembrolizumab, a programmed cell death protein 1 (PD-1) inhibitor, is widely employed in oncological practice; however, its propensity to induce nephrotoxicity through immune-mediated oxidative and inflammatory mechanisms remains an ...
Engin Hendem +7 more
doaj +2 more sources
Potential Benefits of Flunarizine in Patients with Sudden Sensorineural Hearing Loss with Incomplete Recovery Following Conventional Steroid Treatment: A Retrospective Analysis [PDF]
MedicinaObjectives: This study assessed the potential benefits of supplemental flunarizine administration in patients with sudden sensorineural hearing loss (SSNHL) experiencing incomplete recovery with conventional steroid treatment.
Young-Soo Chang, Jeong Hwan Choi
doaj +2 more sources
Still Relevant, Still Effective: A Retrospective Observational Cohort Study on Real-Life Use of Flunarizine in Episodic Migraine [PDF]
Brain SciencesAim: New disease-specific and mechanism-based treatments for migraine that share good evidence of efficacy have recently been introduced. However, due to reimbursement problems with insurance companies and high costs, classical anti-migraine drugs ...
Devrimsel Harika Ertem +2 more
doaj +2 more sources
Flunarizine as a potential repurposed drug for the serotonin transporter inhibition: an integrated approach for therapeutic development against major depressive disorder [PDF]
Frontiers in PharmacologyMajor depressive disorder (MDD) is a serious neuropsychiatric condition that affects millions of people worldwide, causing significant psychological distress and lifestyle deterioration.
Abdelbaset Mohamed Elasbali +8 more
doaj +2 more sources
Fu’s Subcutaneous Needling treatment for migraine without aura: a randomized controlled trial protocol [PDF]
Frontiers in NeurologyIntroductionFu’s Subcutaneous Needling (FSN) is a novel acupuncture technique that has demonstrated significant efficacy in pain management. However, its effectiveness in treating migraine without aura (MWoA) has not been systematically validated ...
Wenqi Guo, Yusha Yang, Jian Sun
doaj +2 more sources
Bioequivalence Study of Two Formulations of Flunarizine Hydrochloride Capsules in Healthy Chinese Subjects Under Fasting and Fed Conditions [PDF]
Drugs in R&DBackground and Objectives Flunarizine, a selective calcium channel blocker with vasodilatory and neuroprotective effects, is a mainstay for migraine prophylaxis and vertigo management. This study aimed to compare the bioequivalence, pharmacokinetics, and
Yinglin Yang +6 more
doaj +2 more sources