Results 31 to 40 of about 4,036 (152)

Case Report: A Novel CACNA1A Mutation Caused Flunarizine-Responsive Type 2 Episodic Ataxia and Hemiplegic Migraine With Abnormal MRI of Cerebral White Matter

Frontiers in Neurology, 2022
Episodic ataxia type 2 (EA2) is one autosomal-dominant neurological disorder characterized by debilitating attacks of ataxia. It is mainly caused by loss-of-function mutations of the CACNA1A gene, which encodes the pore-forming α1A subunit of Cav2.1 (P/Q
Xiaoqiu Yuan, Yiming Zheng, Feng Gao, Wei Sun, Zhaoxia Wang, Guiping Zhao   +5 more
doaj   +1 more source

Inhibition of [3H] dopamine uptake by flunarizine

, 1991
The effect of different calcium channel blockers was studied on basal and cocaine-inhibited [3H]dopamine uptake in rat striatal synaptosomes. Isradipine (dihydropyridine calcium antagonist) and diltiazem (L-type calcium antagonist) were devoid of effect ...
DE MONTIS, M. G., PANI, L., KUZMIN, A., DEVOTO, P.   +3 more
core   +2 more sources

Flunarizine: a review of its role in migraine prophylaxis [PDF]

, 2020
Flunarizine, a potent calcium channel blocker has been used for more than three decades for the prophylactic management of migraine. Theories suggest that flunarizine may act through multiple mechanisms such as inhibition of cortical spreading depression,
Goyal, Vishal, Singh, Sumit, Keny, Mukundraj, Francis, M. V.   +3 more
core   +1 more source

Effect of Flunarizine on Alternating Hemiplegia of Childhood in a Patient with the p.E815K Mutation in ATP1A3: A Case Report

Case Reports in Neurology, 2020
Alternating hemiplegia of childhood (AHC) (MIM 104290) is characterized by transient repeated attacks of paresis on either or both sides of the body, oculomotor and autonomic abnormalities, movement disorders, and cognitive impairment.
Shouichirou Kusunoki, Jun Kido, Ken Momosaki, Takaaki Sawada, Tomoko Kashiki, Shirou Matsumoto, Kimitoshi Nakamura   +6 more
doaj   +1 more source

Flunarizine versus topiramate in migraine prophylaxis and their effect on psychomotor ability: A prospective open-label study

National Journal of Physiology, Pharmacy and Pharmacology
Background: About 9% of the overall population suffers from migraine headaches, with a female majority. For the prevention of migraines, the two most often prescribed drugs are topiramate (TPM) and flunarizine.
Alok Dixit, Devesh Pandey, Nasreen Fatma Khan, Chandraveer Singh, Asha Pathak, Ramakant Yadav   +5 more
doaj   +1 more source

Parkinsonism and other movement disorders in outpatients in chronic use of cinnarizine and flunarizine Parkinsonismo e outros distúrbios do movimento em pacientes ambulatoriais sob uso crônico de cinarizina ou flunarizina

Arquivos de Neuro-Psiquiatria, 2004
The purpose of this study is to determine the prevalence and the patterns of movement disorders (MD) in outpatients submitted to the chronic use of cinnarizine (cz) or flunarizine (fz), and to establish the main risk factors for MD development.
Giorgio Fabiani, Paulo C. Pastro, Carolina Froehner   +2 more
doaj   +1 more source

Redox Biocatalysis in Lidocaine‐Based Hydrophobic Deep Eutectic Solvents: Non‐Conventional Media Outperform Aqueous Conditions

ChemSusChem, Volume 18, Issue 6, March 15, 2025.
Two hydrophobic DESs, lidocaine/oleic acid and lidocaine/decanoic acid, were utilized as reaction media that were enzyme‐compatible and highly substrate‐solubilizer for carbonyl reduction catalyzed by horse liver alcohol dehydrogenase, focusing on the effect of water contents and on maximizing substrate loadings, which showcases for the first time the ...
Ningning Zhang, Viktoria Lahmann, Jan Philipp Bittner, Pablo Domínguez de María, Sven Jakobtorweihen, Irina Smirnova, Selin Kara   +6 more
wiley   +1 more source

Clinical effect of flunarizine combined with duloxetine in the treatment of chronic migraine comorbidity of depression and anxiety disorder

Brain and Behavior, 2022
Background Migraine is common in primary headaches, and with the development of social economy and the increase in living pressure, the prevalence of migraine has an upward trend.
Junliang Zhu, Jianhuang Chen, Kaixue Zhang   +2 more
doaj   +1 more source

Flunarizine Induced Parkinsonism in Migraine Group: A Nationwide Population-Based Study

Frontiers in Pharmacology, 2019
Background: Flunarizine (Fz) is a first-line prophylactic medication that is widely used in migraine. However, Fz has been recognized as a potential cause of drug-induced parkinsonism for a long time.
Wei Lin, Cheng-Li Lin, Chung Y. Hsu, Cheng-Yu Wei, Cheng-Yu Wei   +4 more
doaj   +1 more source

Framework for headache management in pediatric patients with stroke and cerebrovascular lesions: A narrative review

Headache: The Journal of Head and Face Pain, EarlyView.
Abstract Objective To present a practical, evidence‐based framework for the management of headache disorders in pediatric patients with prior stroke or underlying cerebral vascular lesions, with particular attention to safety and efficacy of pharmacologic and non‐pharmacologic therapies.
Allison C. Hyland, Samuel J. Belfer, Christine K. Fox, Samantha L. Irwin, Rachel Vassar, Ann Oh, Sruthi Ilangovan, Amy A. Gelfand   +7 more
wiley   +1 more source