Results 21 to 30 of about 4,036 (152)
Etiology of parkinsonism in a Brazilian movement disorders clinic [PDF]
Arquivos de Neuro-Psiquiatria, 1998 OBJECTIVE: The aim of the present study is to investigate whether there are geographic differences in the etiology of parkinsonism (PA). BACKGROUND: 72% of patients with PA evaluated at movement disorders clinics in the Northern Hemisphere are diagnosed ...
FRANCISCO CARDOSO +2 more
doaj +1 more source
Frontiers in Neurology, 2017 BackgroundDifferent types of medications are currently used in vestibular migraine (VM) prophylaxis, although recommendations for use are generally based on expert opinion rather than on solid data from randomized trials.
Fenye Liu +4 more
doaj +1 more source
A link between agrin signalling and Cav3.2 at the neuromuscular junction in spinal muscular atrophy
Scientific Reports, 2022 SMN protein deficiency causes motoneuron disease spinal muscular atrophy (SMA). SMN-based therapies improve patient motor symptoms to variable degrees. An early hallmark of SMA is the perturbation of the neuromuscular junction (NMJ), a synapse between a ...
Perrine Delers +5 more
doaj +1 more source
Molecular and clinical characteristics of ATP1A3-related diseases
Frontiers in Neurology, 2022 ObjectiveWith detailed studies of ATP1A3-related diseases, the phenotypic spectrum of ATP1A3 has greatly expanded. This study aimed to potentially identify the mechanisms by which ATP1A3 caused neurological dysfunction by analyzing the clinical features ...
Yinchao Li +9 more
doaj +1 more source
Synthesis of [18F]flunarizine [PDF]
, 1991 Flunarizine, a calcium channel antagonist of the piperazine class, has been labeled with the positron-emitter 18F. 4-[18F]Fluoro-4'-fluorobenzhydryl chloride was prepared in three steps from no-carrier-added [18F]fluoride ion, and used in the alkylation ...
Kilbourn, Michael R.
core +1 more source
Flunarizine-loaded microparticles for the prophylaxis of migraine
, 2020 The World Health Organization has listed migraine as the sixth most disabling disorder globally and the most disabling of all neurological disorders. Flunarizine (FZ) is considered a first-line prophylactic treatment for migraine in several guidelines ...
Sandoval, Virginia +3 more
core +1 more source
Frontiers in Neurology, 2021 Alternating hemiplegia of childhood is a rare neurological disease characterized by paroxysmal movement disorders and chronic neurological disturbances, with onset before 18 months of age. Mutations in the ATP1A3 gene have been identified in up to 80% of
Ramona Cordani +10 more
doaj +1 more source
Flunarizine-induced Depression: A Case Report with Review of Literature [PDF]
Indian Journal of Private PsychiatryAim and background: Flunarizine, a cerebro-selective calcium channel blocker, prescribed worldwide for migraine prophylaxis, has demonstrated efficacy and safety in different migraine types and patient populations, comparable to other first-line ...
Gagandeep Ahuja +2 more
doaj +1 more source
Nepal Journal of Neuroscience, 2021 Introduction Primary headache disorder, characterized by recurrent headache is the most prevalent disease leading to widespread ill health and impaired quality of life.
Babu Ram Pokharel +5 more
doaj +1 more source
Novel E815K knock-in mouse model of alternating hemiplegia of childhood
Neurobiology of Disease, 2018 De novo mutations causing dysfunction of the ATP1A3 gene, which encodes the α3 subunit of Na+/K+-ATPase pump expressed in neurons, result in alternating hemiplegia of childhood (AHC).
Ashley R. Helseth +11 more
doaj +1 more source