Results 171 to 180 of about 40,790 (312)

The C‐Terminal Regions of TRAK Proteins Contain MIRO‐Independent Mitochondrial Localization Domains

open access: yesCytoskeleton, EarlyView.
ABSTRACT Current models suggest that MIRO GTPases anchor cytoskeletal motors to the mitochondrial outer membrane (MOM). However, our previous findings indicate that the unconventional myosin, MYO19, interacts with MIRO weakly and that a MIRO‐independent MOM‐localizing domain interacts more tightly with the MOM.
Lili Mitchell   +4 more
wiley   +1 more source

In Vivo Cytoskeletal AMPA Receptor Transport Imaging in C. elegans

open access: yesCytoskeleton, EarlyView.
ABSTRACT Long‐distance intracellular transport of ionotropic glutamate receptors (iGluRs) is essential for proper excitatory synaptic function underlying learning and memory. Many neuropsychiatric and neurodegenerative conditions have abnormal iGluR transport and trafficking, leading to an intense interest in the mechanisms and factors regulating these
Michaelis A. K., Hoerndli F. J.
wiley   +1 more source

Multi‐Energy Integrated Photocatalysis for Antitumor Therapy

open access: yesExploration, EarlyView.
This comprehensive review summarizes recent advancements in piezo‐photocatalysts and photothermal‐photocatalysts for cancer therapy. It begins by outlining the principles of piezo‐photocatalysis and photothermal‐photocatalysis, followed by a discussion of various multi‐energy integrated photocatalysts designed for single‐, dual‐, triple‐, and tetra ...
Li Zhang   +4 more
wiley   +1 more source

Multimode Immunochromatography Assay Based on Portable Instruments for Sensitive and Rapid Detection of Carbendazim in Real Samples

open access: yesFood Safety and Health, EarlyView.
The widespread use of carbendazim in agriculture has led to its residues in food, necessitating a rapid, sensitive, and field‐deployable detection platform. This study developed a multimode immunochromatography assay based on portable instruments for sensitive and rapid detection of carbendazim.
Junqi Shen   +12 more
wiley   +1 more source

Homoharringtonine suppresses acute myeloid leukemia progression by orchestrating EWSR1 phase separation in an m6A‐YTHDF2‐dependent mechanism

open access: yesiMeta, EarlyView.
Homoharringtonine (HHT), a clinically approved anti‐leukemic drug, directly binds the RNA‐binding protein EWSR1. HHT induces an allosteric conformational switch in the RNA recognition motif of EWSR1, driving self‐association and liquid–liquid phase separation (LLPS). The resulting condensates act as regulatory hubs that sequester the m6A reader YTHDF2,
Ting‐Ting Liu   +17 more
wiley   +1 more source

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