Results 91 to 100 of about 102,435 (279)

Advances in the Synthesis and Biological Applications of Enoxacin-Based Compounds

Biomolecules
A comprehensive review of advances in the synthesis and biological applications of enoxacin (1, referred to as ENX)-based compounds is presented. ENX, a second-generation fluoroquinolone (FQ), is a prominent 1,8-naphthyridine containing compounds studied
Garba Suleiman, Nabil El Brahmi, Gérald Guillaumet, Saïd El Kazzouli   +3 more
doaj   +1 more source

Delafloxacin suppresses DEPDC1 expression and induces G2/M arrest in non‐small cell lung cancer cells: A drug repurposing study

Smart Molecules, EarlyView.
This study presents Delafloxacin repurposed as a DEPDC1‐targeting therapeutic aiming to suppress lung cancer progression. It highlights a novel strategy for lung cancer treatment with potential clinical applications. Abstract Emerging evidence highlights the oncogenic role of the Dishevelled, Egl‐10, and Pleckstrin domains containing 1 (DEPDC1) gene in
Noman Ali, Farishta Shafiq, Mishal Iftikhar, Muhammad Shahzad Zafar, Muhammad Shoaib   +4 more
wiley   +1 more source

Should we review our prophylaxis approach for increased antibiotic resistance in transrectal prostate biopsy?

Journal of Infection in Developing Countries
Introduction: This study aims to show the bacteriologic picture of acute prostatitis and bacteremia caused by infective agent after transrectal ultrasound-guided prostate biopsy (TRUSBx) and to determine the resistance rates of the infections in ...
Adalet Altunsoy, Şeref Coşer, Nizamettin Kemirtlek, Ibrahim Can Aykanat, Melih Balci, Hürrem Bodur, Altuğ Tuncel   +6 more
doaj   +1 more source

‘Knowledge, attitudes and practices’ survey of Austrian veterinarians' antibiotic use in clinical practice

Veterinary Record, EarlyView.
Abstract Background Antimicrobial resistance (AMR) is a critical global health issue, with antimicrobial use (AMU) in veterinary medicine playing a relevant role in its emergence. This study aimed to evaluate the knowledge, attitudes and practices of Austrian veterinarians regarding AMU and AMR.
Clair L. Firth, Patricia Mayer, Annemarie Käsbohrer, Tanja Tripolt, Klemens Fuchs   +4 more
wiley   +1 more source

Reusing health records from farm animal practices at scale: A potential complementary method of surveillance

Veterinary Record, EarlyView.
Abstract Background Disease in primary care frequently represents a surveillance blind spot, particularly for diseases affecting farm animals. Methods Electronic health records (EHRs) were collected from four farm animal veterinary practices in Wales (February 2024‒January 2025) as part of a pilot study.
Beverley Hopkins, Peers Davies, Peter‐John Noble, Anna Bunford‐Davies, April Lawson, Gina Pinchbeck, Ifan Lloyd, Robert Smith, Alan D. Radford   +8 more
wiley   +1 more source

Development of a Magnetic Solid-Phase Extraction-Liquid Chromatography Targeted to Five Fluoroquinolones in Food Based on Aptamer Recognition

Foods
Fluoroquinolones (FQs) are present in trace amounts in the environment, from where they enter animal- and plant-derived food products. Long-term exposure to low-dose drugs poses a risk to human health and increases the pressure on antibiotic selection ...
Haiyan Zhou, Xiaofeng Yan, Yaning Song, Xiao Yang, Xianggui Chen, Yukun Huang   +5 more
doaj   +1 more source

Prevalence of Beta-Lactam and Quinolone/Fluoroquinolone Resistance in Enterobacteriaceae From Dogs in France and Spain—Characterization of ESBL/pAmpC Isolates, Genes, and Conjugative Plasmids

Frontiers in Veterinary Science, 2019
Quantitative data on fecal shedding of antimicrobial-resistant bacteria are crucial to assess the risk of transmission from dogs to humans. Our first objective was to investigate the prevalence of quinolone/fluoroquinolone-resistant and beta-lactam ...
Véronique Dupouy, Mouni Abdelli, Gabriel Moyano, Nathalie Arpaillange, Delphine Bibbal, Marie-Christine Cadiergues, Diego Lopez-Pulin, Sakina Sayah-Jeanne, Jean de Gunzburg, Nathalie Saint-Lu, Bruno Gonzalez-Zorn, Antoine Andremont, Alain Bousquet-Mélou   +12 more
doaj   +1 more source

Isolation of carbapenem‐resistant Pseudomonas aeruginosa and other Gram‐negative ESKAPE organisms from samples of raw‐meat diets for dogs in the UK

Veterinary Record, EarlyView.
Abstract Background Gram‐negative ESKAPE organisms are an emerging threat in veterinary medicine that also have zoonotic potential. However, little is known about the prevalence and risks of these organisms in pet food. We present the incidental finding of gram‐negative ESKAPE organisms within samples of raw meat diets for dogs in the United Kingdom ...
Genever Morgan, Nicola Williams, Jenny Llewelyn, Sam Haldenby, Gina Pinchbeck, Dorina Timofte   +5 more
wiley   +1 more source

Seasonal Determination of Antibiotic-Resistant Microorganisms and Ciprofloxacin Residues in Pork and Chicken Meats Collected from Fresh Markets in Chiang Mai, Northern Thailand

Foods
Antibiotic-resistant bacteria are usually found in food-producing animals worldwide. Ciprofloxacin, an antibiotic, can lead to antibiotic residues in food products, posing health risks to consumers and contributing to the development of antimicrobial ...
Sirikwan Dokuta, Sumed Yadoung, Sayamon Hongjaisee, Phadungkiat Khamnoi, Sirinya Manochomphu, Bajaree Chuttong, Surat Hongsibsong   +6 more
doaj   +1 more source

Relative Fitness of Fluoroquinolone-resistant Streptococcus pneumoniae

Emerging Infectious Diseases, 2005
Fluoroquinolone resistance in Streptococcus pneumoniae is primarily mediated by point mutations in the quinolone resistance–determining regions of gyrA and parC.
Crystal N. Johnson, David E. Briles, William H. Benjamin, Susan K. Hollingshead, Ken B. Waites   +4 more
doaj   +1 more source