Results 71 to 80 of about 102,435 (279)

Potent monoclonal antibodies against multidrug‐resistant hypervirulent Klebsiella pneumoniae

Interdisciplinary Medicine, EarlyView.
A novel immunization strategy using a low‐virulence, multidrug‐resistant strain yields synergistic monoclonal antibodies against hypervirulent Klebsiella pneumoniae. These antibodies provide cross‐serotype protection through a dual‐mechanism of pathogen clearance and immunomodulation, offering a promising non‐antibiotic therapeutic for resistant ...
Yushan Jiang, Zhuolin Li, Yang Yang, Zihan He, Tyuji Hoshino, Vladislav Victorovich Khrustalev, Qing Zhu, Weiling Wu, Wei Zhao, Chenguang Shen, Shi Ouyang   +10 more
wiley   +1 more source

Relative and Absolute Risk of Tendon Rupture with Fluoroquinolone and Concomitant Fluoroquinolone/Corticosteroid Therapy: Population-Based Nested Case–Control Study

Clinical drug investigation, 2018
Background and ObjectiveTendon rupture can result from fluoroquinolone exposure. The objective of this study was to quantify relative and absolute risk and determine how risk is affected by timing of exposure.MethodsThe UK Health Improvement Network ...
D. Morales, J. Slattery, A. Pacurariu, Luis C Pinheiro, P. McGettigan, X. Kurz   +5 more
semanticscholar   +1 more source

Duplex Recombinase Polymerase Amplification‐Lateral Flow Assay for Rapid Visual Detection of Critical Antibiotic Resistance Genes in Escherichia coli and Klebsiella pneumoniae From Positive Blood Cultures

Journal of Clinical Laboratory Analysis, EarlyView.
This study developed a pair of duplex RPA‐LFA assays for the simultaneous detection of critical resistance genes, blaCTX‐M/mcr‐1 and blaoxa‐48‐like/blaNDM, from hemoculture samples. Under optimized conditions, duplex RPA was performed at 37°C–38°C for 25 min, followed by LFA for 10–15 min.
Variya Nemidkanam, Pattamaporn Deechart, Nuntaree Chaichanawongsaroj   +2 more
wiley   +1 more source

Design and microwave-assisted synthesis of a novel Mannich base and conazole derivatives and their biological assessment

Heterocyclic Communications, 2021
4-Amino-5-methyl-2,4-dihydro-3H-1,2,4-triazol-3-one (1) was converted to the corresponding Schiff base (2) by treatment with salicylaldehyde. 1,2,4-Triazoles were then converted to the corresponding Mannich bases containing fluroquinolone core using a ...
Cebeci Yıldız Uygun, Karaoğlu Şengül Alpay   +1 more
doaj   +1 more source

Sequential Acquisition of Virulence and Fluoroquinolone Resistance Has Shaped the Evolution of Escherichia coli ST131

mBio, 2016
Escherichia coli ST131 is the most frequently isolated fluoroquinolone-resistant (FQR) E. coli clone worldwide and a major cause of urinary tract and bloodstream infections.
Nouri L. Ben Zakour, Areej S. Alsheikh-Hussain, M. Ashcroft, Nguyen Thi Khanh Nhu, Leah W. Roberts, Mitchell Stanton-Cook, M. Schembri, S. Beatson   +7 more
semanticscholar   +1 more source

Complicated Acute Appendicitis Conservatively Treated in Two Patients With Crohn's Disease: The Role of Intestinal Ultrasound and Contrast‐Enhanced Ultrasound

Journal of Clinical Ultrasound, EarlyView.
Intestinal ultrasound and contrast‐enhanced ultrasound were used to diagnose, monitor, and guide conservative treatment of complicated acute appendicitis in two patients with Crohn's disease. Serial imaging enabled early identification of treatment response, allowing long‐term surgery‐free outcomes.
Cataletti Giovanni, Gridavilla Daniele, Nylund Kim, Colombo Francesco, Danelli Piergiorgio, Maconi Giovanni   +5 more
wiley   +1 more source

Effects of earthworms on the fate of tetracycline and fluoroquinolone resistance genes of sewage sludge during vermicomposting.

Bioresource Technology, 2018
Diverse antibiotic resistance genes (ARGs) present in sewage sludge are difficult to be eliminated using conventional sludge treatment processes. To date, little remains known on the fate of the ARGs during vermicomposting of sludge.
Kui Huang, Hui Xia, Ying Wu, Jingyang Chen, Guangyu Cui, Fusheng Li, Yongzhi Chen, Nan Wu   +7 more
semanticscholar   +1 more source

Detecting Antibiotic Resistance in Strains of Selected Gram‐Negative Bacterial Species Using Raman Spectroscopy

Journal of Raman Spectroscopy, EarlyView.
Raman spectroscopy successfully identified antibiotic‐resistant Gram‐negative strains. Resistant strains of four bacterial species were discriminated from sensitive ones with 99.1% accuracy using PLS regression. The method allows for rapid, label‐free detection of antibiotic resistance.
Fernanda Sant Ana de Siqueira e Oliveira, Adriano Moraes da Silva, Marcos Tadeu T. Pacheco, Landulfo Silveira Jr.   +3 more
wiley   +1 more source

Admission Plasma Lipopolysaccharide‐binding protein, Procalcitonin, and Lactate for Early Identification of Nosocomial Infection in Cirrhotic Patients With Upper Gastrointestinal Bleeding: A Retrospective Analysis

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT This study aimed to assess whether admission plasma lipopolysaccharide‐binding protein (LBP), procalcitonin (PCT), and lactate could improve detection of nosocomial infection in cirrhotic patients presenting with upper gastrointestinal bleeding (UGIB).
Li Chen, Shan‐Shan Dun, Fang Xiao
wiley   +1 more source

Increasing Macrolide and Fluoroquinolone Resistance in Mycoplasma genitalium

Emerging Infectious Diseases, 2017
Escalating resistance to azithromycin and moxifloxacin is being reported for Mycoplasma genitalium in the Asia-Pacific region. Analyzing 140 infections, we found pretreatment fluoroquinolone-resistance mutations in parC (13.6%) and gyrA (5%).
Gerald L. Murray, C. Bradshaw, M. Bissessor, J. Danielewski, S. Garland, J. Jensen, C. Fairley, S. Tabrizi   +7 more
semanticscholar   +1 more source