Results 111 to 120 of about 75,972 (251)

Ciprofloxacin is an inhibitor of the Mcm2-7 replicative helicase

Bioscience Reports, 2013
Most currently available small molecule inhibitors of DNA replication lack enzymatic specificity, resulting in deleterious side effects during use in cancer chemotherapy and limited experimental usefulness as mechanistic tools to study DNA replication ...
Anthony Schwacha, William L. Seibel, Jeffrey L. Brodsky, Sandlin Seguin, Matthew L. Bochman, Nicholas Simon   +5 more
doaj   +1 more source

Single-nucleotide polymorphisms related to fluoroquinolone and aminoglycoside resistance in Mycobacterium avium isolates

, 2018
Hui Pang,1,2 Kanglin Wan,3 Lin Wei1 1Department of Immunology, Hebei Medical University, Shijiazhuang, Hebei, China; 2Department of Immunology, Changzhi Medical College, Changzhi, Shanxi, China; 3State Key Laboratory for Infectious Disease Prevention and
Wan K, Pang H, Wei L
core  

Advancing Therapies for Mycobacterial Diseases: From Small Molecules to Host‐Directed Strategies

Medicinal Research Reviews, EarlyView.
ABSTRACT The global burden of multidrug‐resistant tuberculosis (MDR‐TB) and the rising incidence of nontuberculous mycobacterial (NTM) infections highlight the urgent need for innovative therapeutic strategies. Current treatments are prolonged, toxic, and increasingly compromised by resistance and limited diagnostic capacity.
Tânia Silva, Alessandra Aiello, Tonino Alonzi, M. Alice Carvalho, Vladimir Finger, Delia Goletti, Sven Hoffner, Yousra Kherabi, Jan Korabecny, Julia Kulczyńska, Agnieszka Kyzioł, Alicia Lacoma, Filomena Martins, Zorica Nanovic, Sepideh Hosseiniporgham, Martina Hrast Rambaher, Leonardo Antonio Sechi, Daria Smalchuk, Grażyna Stochel, Lydia Tabernero, Nancy L. Tateosian, Violeta Valcheva, Anamarija Zega, Mafalda Sarraguça   +23 more
wiley   +1 more source

Mechanistic insights into HipA‐mediated bacterial persistence: Role of initial cellular states and toxin expression kinetics

mLife, EarlyView.
Abstract Persistent bacteria subpopulations showing multidrug tolerance pose significant challenges to antibiotic therapy. While the HipBA toxin–antitoxin (TA) system is known to play a role in persister formation, existing studies predominantly focus on its kinase activity and intracellular regulatory pathways, with limited attention to the ...
Jing Zhao, Yixiao Xiong, Hongxia Zhao, Jin Wang, Xiaona Fang   +4 more
wiley   +1 more source

Evaluation of Antibiotic Biodegradation by a Versatile and Highly Active Recombinant Laccase from the Thermoalkaliphilic Bacterium Bacillus sp. FNT

Biomolecules
Laccases are industrially relevant enzymes that have gained great biotechnological importance. To date, most are of fungal and mesophilic origin; however, enzymes from extremophiles possess an even greater potential to withstand industrial conditions. In
Jorge Sánchez-SanMartín, Sebastián L. Márquez, Giannina Espina, Rodrigo Cortés-Antiquera, Junsong Sun, Jenny M. Blamey   +5 more
doaj   +1 more source

Non-Monotonic Survival of Staphylococcus aureus with Respect to Ciprofloxacin Concentration Arises from Prophage-Dependent Killing of Persisters

Pharmaceuticals, 2015
Staphylococcus aureus is a notorious pathogen with a propensity to cause chronic, non-healing wounds. Bacterial persisters have been implicated in the recalcitrance of S. aureus infections, and this motivated us to examine the persistence of S. aureus to
Elizabeth L. Sandvik, Christopher H. Fazen, Theresa C. Henry, Wendy W.K. Mok, Mark P. Brynildsen   +4 more
doaj   +1 more source

Systemic use of fluoroquinolone in children [PDF]

, 2013
Fluoroquinolones are an important class of antibiotics that are widely used in adult patients because of their broad spectrum of activity, good tissue penetration, and oral bioavailability.
Yae-Jean Kim, Soo-Han Choi, Eun Young Kim   +2 more
core   +1 more source

Iron Ion‐Mediated Nitrogen‐Doped Carbon Dot Fluorescence Sensing for Accurate Detection of Fluoroquinolone in Food

Food Frontiers
Safety incidents involving the presence of fluoroquinolones (FQs) residues in animal‐derived food are frequently reported, posing a significant threat to human health. Here, we constructed a fluorescence sensing method using iron ions as a bridge for the
Jinyan Luo, Yulong Han, Zikang Hu, Guanghua Lei, Huanhuan Lu, Hengye Chen, Li Yang, Xinming Lv, Wanjun Long, Haiyan Fu   +9 more
doaj   +1 more source

parC Mutations in Fluoroquinolone-Resistant Borrelia Burgdorfeti [PDF]

, 2005
We have isolated in vitro fluoroquinolone-resistant mutants of the Lyme disease agent, Borrelia burgdorferi. Mutations in parC, which encodes a subunit of topoisomerase IV, were associated with loss of susceptibility to sparfloxacin, moxifloxacin, and ...
Kuchel, Craig R., Eggers, Christian H., Ng, Amanda C., Samuels, D. Scott, Galbraith, Kendal M., Eggers, Betsy J.   +5 more
core  

Genetic diversity in fluoroquinolone and macrolide-resistant Campylobacter coli from pigs

, 2006
The genetic diversity of 115 Campylobacter coli strains, isolated from pigs of 59 geographical distant farms in Switzerland, were characterized on the basis of their DNA fingerprints and resistance to macrolides and fluoroquinolones.
Perreten, Vincent, Keller, Jan
core   +1 more source