Results 31 to 40 of about 102,435 (279)

Gyrase and Topoisomerase IV: Recycling Old Targets for New Antibacterials to Combat Fluoroquinolone Resistance

ACS Infectious Diseases
Beyond their requisite functions in many critical DNA processes, the bacterial type II topoisomerases, gyrase and topoisomerase IV, are the targets of fluoroquinolone antibacterials.
Jessica A Collins, Neil Osheroff
semanticscholar   +1 more source

Navigating fluoroquinolone resistance in Gram-negative bacteria: a comprehensive evaluation

JAC-Antimicrobial Resistance
Since the introduction of quinolone and fluoroquinolone antibiotics to treat bacterial infections in the 1960s, there has been a pronounced increase in the number of bacterial species that have developed resistance to fluoroquinolone treatment.
Linda Kherroubi, Joanna Bacon, Khondaker Miraz Rahman   +2 more
semanticscholar   +1 more source

Association Between Peripheral Neuropathy and Exposure to Oral Fluoroquinolone or Amoxicillin-Clavulanate Therapy.

JAMA Neurology, 2019
Importance Peripheral neuropathy has been associated with systemic fluoroquinolone exposure, but risk has been poorly quantified. Objective To calculate relative and absolute risk estimates for the association of fluoroquinolone exposure with ...
D. Morales, A. Pacurariu, J. Slattery, Luis C Pinheiro, P. McGettigan, X. Kurz   +5 more
semanticscholar   +1 more source

Fluoroquinolone heteroresistance, antimicrobial tolerance, and lethality enhancement

Frontiers in Cellular and Infection Microbiology, 2022
With tuberculosis, the emergence of fluoroquinolone resistance erodes the ability of treatment to interrupt the progression of MDR-TB to XDR-TB.
Amit Singh, Amit Singh, Xilin Zhao, Xilin Zhao, Karl Drlica   +4 more
doaj   +1 more source

Fluoroquinolone Efficacy against Tuberculosis Is Driven by Penetration into Lesions and Activity against Resident Bacterial Populations

Antimicrobial Agents and Chemotherapy, 2019
Fluoroquinolones represent the pillar of multidrug-resistant tuberculosis (MDR-TB) treatment, with moxifloxacin, levofloxacin, or gatifloxacin being prescribed to MDR-TB patients.
Jansy P. Sarathy, L. Blanc, Nadine Alvarez-Cabrera, P. O’Brien, Isabela Dias-Freedman, Marizel Mina, M. Zimmerman, Firat Kaya, Hsin-Pin Ho Liang, Brendan Prideaux, Jillian Dietzold, P. Salgame, R. Savic, J. Linderman, D. Kirschner, Elsje Pienaar, V. Dartois   +16 more
semanticscholar   +1 more source

Fluoroquinolone antibiotics: An overview

Adesh University Journal of Medical Sciences & Research, 2020
Fluoroquinolones are the type of antibacterial agents more extensively used from the past few years and will be continued to be used even in the next decade.
R. K. Brar, Uma Jyoti, R. K. Patil, H. C. Patil   +3 more
semanticscholar   +1 more source

The Effectiveness and Safety of Fluoroquinolone-Containing Regimen as a First-Line Treatment for Drug-Sensitive Pulmonary Tuberculosis: A Systematic Review and Meta-Analysis.

PLoS ONE, 2016
BackgroundFluoroquinolone is recommended as a pivotal antituberculous agent for treating multi-drug-resistant pulmonary tuberculosis. However, its effectiveness as first-line treatment remains controversial.
Hyun Woo Lee, Jung Kyu Lee, Eunyoung Kim, Jae-Joon Yim, Chang-Hoon Lee   +4 more
doaj   +1 more source

Fluoroquinolone resistance in Salmonella: insights by whole-genome sequencing

Microbial Genomics, 2018
Fluoroquinolone (FQ)-resistant Salmonella spp. were listed by the WHO in 2017 as priority pathogens for which new antibiotics were urgently needed. The overall global burden of Salmonella infections is high, but differs per region.
Wim L. Cuypers, J. Jacobs, V. Wong, Elizabeth J. Klemm, S. Deborggraeve, S. Van Puyvelde   +5 more
semanticscholar   +1 more source

Toward Chromoselective Transformations in Biological Systems: Perspectives and Challenges

Angewandte Chemie International Edition, EarlyView.
Controlling biological systems with small‐molecule chromophores has evolved into a powerful strategy and is applied from chemical biology to medicine. However, the complexity of in vivo systems cannot be matched by a single wavelength of light. Developing methods to combine and individually control multiple chromophores is crucial.
Nadja A. Simeth
wiley   +1 more source

Nalidixic acid—a good marker of fluoroquinolone resistance mechanisms in Escherichia coli

Microbiology Spectrum
The purpose of this study was to evaluate how ciprofloxacin, pefloxacin, and nalidixic acid disks perform in screening fluoroquinolone resistance mechanisms in 278 Escherichia coli isolates collected from a prospective clinical material.
Sofia Kalinen, Heini Kallio, Teemu Kallonen, Juha Knaapila, Tarja Lamminen, Pentti Huovinen, Peter Boström, Antti J. Hakanen, Marianne Gunell   +8 more
doaj   +1 more source