Results 21 to 30 of about 102,435 (279)

Fluoroquinolones and Anaerobes [PDF]

Clinical Infectious Diseases, 2006
The usefulness of fluoroquinolones for the treatment of mixed aerobic and anaerobic infections has been investigated since these agents started being used in clinical practice. Newer compounds have increased in vitro activity against anaerobes, but clinically relevant susceptibility breakpoints for these bacteria have not been established ...
Gary E, Stein, Ellie J C, Goldstein
openaire   +2 more sources

The challenge of intracellular antibiotic accumulation, a function of fluoroquinolone influx versus bacterial efflux

Communications Biology, 2020
With the spreading of antibiotic resistance, the translocation of antibiotics through bacterial envelopes is crucial for their antibacterial activity. In Gram-negative bacteria, the interplay between membrane permeability and drug efflux pumps must be ...
Julia Vergalli, Alessio Atzori, Jelena Pajović, Estelle Dumont, G. Malloci, Muriel Masi, A. Vargiu, M. Winterhalter, M. Réfrégiers, P. Ruggerone, J. Pagés   +10 more
semanticscholar   +1 more source

Enhanced antibiotic resistance development from fluoroquinolone persisters after a single exposure to antibiotic

Nature Communications, 2019
Bacterial persisters are able to tolerate high levels of antibiotics and give rise to new populations. Persister tolerance is generally attributed to minimally active cellular processes that prevent antibiotic-induced damage, which has led to the ...
T. Barrett, Wendy W. K. Mok, Allison M Murawski, M. P. Brynildsen   +3 more
semanticscholar   +1 more source

Discovery of a Novel Mutation in DNA Gyrase and Changes in the Fluoroquinolone Resistance of Helicobacter pylori over a 14-Year Period: A Single Center Study in Korea

Antibiotics, 2020
The efficacy of fluoroquinolone-based eradication therapy largely depends on the fluoroquinolone resistance of H. pylori. The aim of this study was to investigate the changes in the primary resistance rate of H.
Su Yeon Rhie, Jae Yong Park, Tae-Seop Shin, Jeong Wook Kim, Beom Jin Kim, Jae Gyu Kim   +5 more
doaj   +1 more source

Comparing the Synergistic and Antagonistic Interactions of Ciprofloxacin and Levofloxacin Combined with Rifampin against Drug-Resistant Staphylococcus aureus: A Time–Kill Assay

Antibiotics, 2023
Background: Treatment of device-related infections by drug-resistant Staphylococcus aureus can be challenging, and combination therapy has been proposed as a potential solution.
Yu Ri Kang, Doo Ryeon Chung, Jae-Hoon Ko, Kyungmin Huh, Sun Young Cho, Cheol-In Kang, Kyong Ran Peck   +6 more
doaj   +1 more source

The insulinotropic effect of fluoroquinolones [PDF]

Biochemical Pharmacology, 2009
Antimicrobial fluoroquinolones induce, with strongly varying frequency, life-threatening hypoglycemias, which is explained by their ability to block K(ATP) channels in pancreatic B-cells and thus to initiate insulin secretion. In apparent contradiction to this, we observed that none of the fluoroquinolones in this study (gatifloxacin, moxifloxacin ...
Ghaly, Hani, Kriete, Christine, Sahin, Seher, Pflöger, Anja, Holzgrabe, Ulrike, Zünkler, Bernd Joachim, Rustenbeck, Ingo   +6 more
openaire   +2 more sources

Fluoroquinolone-Resistant Escherichia coli Infections after Transrectal Biopsy of the Prostate in the Veterans Affairs Healthcare System

Pathogens and Immunity, 2016
Background: Recent reports suggest that infections due to fluoroquinolone-resistant Escherichia coli (E. coli) are an increasingly common complication of transrectal biopsy of the prostate (TBP) in the United States.
Elie Antoun Saade, Nuntra Suwantara, Trina F. Zabarsky, Brigid Wilson, Curtis J. Donskey   +4 more
doaj   +1 more source

Pseudomonas aeruginosa, Staphylococcus aureus, and Fluoroquinolone Use

Emerging Infectious Diseases, 2005
Few long-term multicenter investigations have evaluated the relationships between aggregate antimicrobial drug use in hospitals and bacterial resistance. We measured fluoroquinolone use from 1999 through 2003 in a network of US hospitals. The percentages
Conan MacDougall, Spencer E. Harpe, J. Patrick Powell, Christopher K. Johnson, Michael B. Edmond, Ron E. Polk   +5 more
doaj   +1 more source

Ofloxacin-induced Fixed Drug Eruptions

Journal of Integrated Health Sciences, 2020
Fixed drug eruption (FDE) is a form of drug induced dermatosis condition. Drugs which most commonly induce FDE are antibiotics, anticonvulsants, antiviral agents and even nonsteroidal anti-inflammatory drugs.
Kushalkumar H. Gohel, Kusum V. Shah, Shivani Patel, Juliet Joy Joseph, Jilce Mathew   +4 more
doaj   +1 more source

Impact of Reduced Fluoroquinolone Use on Clostridioides difficile Infections Resulting From the Fluoroquinolone-Resistant Ribotype 027 Strain in a Veterans Affairs Medical Center

Pathogens and Immunity, 2019
Background: Fluoroquinolone restriction has been proposed as a control measure for Clostridioides difficile infection (CDI) outbreaks associated with fluoroquinolone-resistant ribotype 027 strains.
Sarah N. Redmond, Sandra Y. Silva, Brigid M. Wilson, Jennifer L. Cadnum, Curtis J. Donskey   +4 more
doaj   +1 more source